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Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
J Neurosci 2008; 28(51):13856-65JN

Abstract

A common feature of drugs of abuse is their ability to increase extracellular dopamine levels in key brain circuits. The actions of dopamine within these circuits are thought to be important in reward and addiction-related behaviors. Current theories of addiction also posit a central role for corticotrophin-releasing factor (CRF) and an interaction between CRF and monoaminergic signaling. One region where drugs of abuse promote robust rises in extracellular dopamine levels is the bed nucleus of the stria terminalis (BNST), a CRF-rich component of the extended amygdala. We find that dopamine rapidly enhances glutamatergic transmission in the BNST through activation of a combination of D(1)- and D(2)-like receptors. This enhancement is activity-dependent and requires the downstream action of CRF receptor 1 (CRF-R1), suggesting that dopamine induces CRF release through a local network mechanism. Furthermore, we found that both in vivo and ex vivo cocaine induced a dopamine receptor and CRF-R1-dependent enhancement of a form of NMDA receptor-dependent short-term potentiation in the BNST. These data highlight a direct and rapid interaction between dopamine and CRF systems that regulates excitatory transmission and plasticity in a brain region key to reinforcement and reinstatement. Because a rise in extracellular dopamine levels in the BNST is a shared consequence of multiple classes of drugs of abuse, this suggests that the CRF-R1-dependent enhancement of glutamatergic transmission in this region may be a common key feature of substances of abuse.

Authors+Show Affiliations

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19091975

Citation

Kash, Thomas L., et al. "Dopamine Enhances Fast Excitatory Synaptic Transmission in the Extended Amygdala By a CRF-R1-dependent Process." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 28, no. 51, 2008, pp. 13856-65.
Kash TL, Nobis WP, Matthews RT, et al. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. J Neurosci. 2008;28(51):13856-65.
Kash, T. L., Nobis, W. P., Matthews, R. T., & Winder, D. G. (2008). Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 28(51), pp. 13856-65. doi:10.1523/JNEUROSCI.4715-08.2008.
Kash TL, et al. Dopamine Enhances Fast Excitatory Synaptic Transmission in the Extended Amygdala By a CRF-R1-dependent Process. J Neurosci. 2008 Dec 17;28(51):13856-65. PubMed PMID: 19091975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. AU - Kash,Thomas L, AU - Nobis,William P, AU - Matthews,Robert T, AU - Winder,Danny G, PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/1/13/medline SP - 13856 EP - 65 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J. Neurosci. VL - 28 IS - 51 N2 - A common feature of drugs of abuse is their ability to increase extracellular dopamine levels in key brain circuits. The actions of dopamine within these circuits are thought to be important in reward and addiction-related behaviors. Current theories of addiction also posit a central role for corticotrophin-releasing factor (CRF) and an interaction between CRF and monoaminergic signaling. One region where drugs of abuse promote robust rises in extracellular dopamine levels is the bed nucleus of the stria terminalis (BNST), a CRF-rich component of the extended amygdala. We find that dopamine rapidly enhances glutamatergic transmission in the BNST through activation of a combination of D(1)- and D(2)-like receptors. This enhancement is activity-dependent and requires the downstream action of CRF receptor 1 (CRF-R1), suggesting that dopamine induces CRF release through a local network mechanism. Furthermore, we found that both in vivo and ex vivo cocaine induced a dopamine receptor and CRF-R1-dependent enhancement of a form of NMDA receptor-dependent short-term potentiation in the BNST. These data highlight a direct and rapid interaction between dopamine and CRF systems that regulates excitatory transmission and plasticity in a brain region key to reinforcement and reinstatement. Because a rise in extracellular dopamine levels in the BNST is a shared consequence of multiple classes of drugs of abuse, this suggests that the CRF-R1-dependent enhancement of glutamatergic transmission in this region may be a common key feature of substances of abuse. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/19091975/Dopamine_enhances_fast_excitatory_synaptic_transmission_in_the_extended_amygdala_by_a_CRF_R1_dependent_process_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=19091975 DB - PRIME DP - Unbound Medicine ER -