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Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders.
J Endocrinol Invest. 2008 Oct; 31(10):861-5.JE

Abstract

OBJECTIVE

We determined the autoantibody profile in autoimmune thyroid diseases (AITD) and examined the distribution of thyroid-related autoantibodies in other autoimmune disorders.

METHODS

We tested sera from 234 patients with Graves' disease (GD), 130 with Hashimoto's thyroiditis (HT), 249 with other autoimmune diseases, and 50 healthy controls by enzyme-linked immunosorbent assay or radioimmunoassay.

RESULTS

Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and anti-thyroid peroxidase (TPO) Ab were not significantly prevalent in patients with AITD despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to AITD was observed in type 1 diabetes patients. Elevation of anti-Tg Ab was seen in patients with primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH), and anti-TPO Ab was elevated in patients with PBC. Although the prevalence of anti-acetylcholine receptor Ab and systemic lupus erythematosus (SLE)- related Ab was significant in AIH, primary Sjögren's syndrome (pSS)-related Ab were also found in both liver diseases. In myasthenia gravis (MG) patients, thyroid-related Ab and pSS-related Ab were detected in both MG groups, although SLE-related Ab were limited to the anti-muscle specific kinase Ab-positive MG patients. In patients with connective tissue diseases, anti- Tg Ab and anti-TPO Ab were significantly prevalent.

CONCLUSION

Thyroid-related Ab were significantly elevated in all autoimmune diseases. Conversely, the elevations of Ab were not significant in the patients with AITD, suggesting a close relationship between AITD and other immune-mediated diseases.

Authors+Show Affiliations

The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Nagasaki, Japan. nhideki@nagasaki-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19092289

Citation

Nakamura, H, et al. "Prevalence of Interrelated Autoantibodies in Thyroid Diseases and Autoimmune Disorders." Journal of Endocrinological Investigation, vol. 31, no. 10, 2008, pp. 861-5.
Nakamura H, Usa T, Motomura M, et al. Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. J Endocrinol Invest. 2008;31(10):861-5.
Nakamura, H., Usa, T., Motomura, M., Ichikawa, T., Nakao, K., Kawasaki, E., Tanaka, M., Ishikawa, K., & Eguchi, K. (2008). Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. Journal of Endocrinological Investigation, 31(10), 861-5.
Nakamura H, et al. Prevalence of Interrelated Autoantibodies in Thyroid Diseases and Autoimmune Disorders. J Endocrinol Invest. 2008;31(10):861-5. PubMed PMID: 19092289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. AU - Nakamura,H, AU - Usa,T, AU - Motomura,M, AU - Ichikawa,T, AU - Nakao,K, AU - Kawasaki,E, AU - Tanaka,M, AU - Ishikawa,K, AU - Eguchi,K, PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/2/28/medline SP - 861 EP - 5 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 31 IS - 10 N2 - OBJECTIVE: We determined the autoantibody profile in autoimmune thyroid diseases (AITD) and examined the distribution of thyroid-related autoantibodies in other autoimmune disorders. METHODS: We tested sera from 234 patients with Graves' disease (GD), 130 with Hashimoto's thyroiditis (HT), 249 with other autoimmune diseases, and 50 healthy controls by enzyme-linked immunosorbent assay or radioimmunoassay. RESULTS: Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and anti-thyroid peroxidase (TPO) Ab were not significantly prevalent in patients with AITD despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to AITD was observed in type 1 diabetes patients. Elevation of anti-Tg Ab was seen in patients with primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH), and anti-TPO Ab was elevated in patients with PBC. Although the prevalence of anti-acetylcholine receptor Ab and systemic lupus erythematosus (SLE)- related Ab was significant in AIH, primary Sjögren's syndrome (pSS)-related Ab were also found in both liver diseases. In myasthenia gravis (MG) patients, thyroid-related Ab and pSS-related Ab were detected in both MG groups, although SLE-related Ab were limited to the anti-muscle specific kinase Ab-positive MG patients. In patients with connective tissue diseases, anti- Tg Ab and anti-TPO Ab were significantly prevalent. CONCLUSION: Thyroid-related Ab were significantly elevated in all autoimmune diseases. Conversely, the elevations of Ab were not significant in the patients with AITD, suggesting a close relationship between AITD and other immune-mediated diseases. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/19092289/Prevalence_of_interrelated_autoantibodies_in_thyroid_diseases_and_autoimmune_disorders_ L2 - https://link.springer.com/article/10.1007/BF03346432 DB - PRIME DP - Unbound Medicine ER -