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Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial.
Ann Surg. 2008 Dec; 248(6):1031-41.AnnS

Abstract

BACKGROUND

Success of surgical treatment for pancreatic and periampullary cancer is often limited due to locoregional recurrence and/or the development of distant metastases.

OBJECTIVE

The survival benefit of celiac axis infusion (CAI) and radiotherapy (RT) versus observation after resection of pancreatic or periampullary cancer was investigated.

METHODS

In a randomized controlled trial, 120 consecutive patients with histopathologically proven pancreatic or periampullary cancer received either adjuvant treatment consisting of intra-arterial mitoxantrone, 5-FU, leucovorin, and cisplatinum in combination with 30 x 1.8 Gy radiotherapy (group A) or no adjuvant treatment (group B). Groups were stratified for tumor type (pancreatic vs. periampullary tumors).

RESULTS

After surgery, 120 patients were randomized (59 patients in the treatment group, 61 in the observation group). The median follow-up was 17 months. No significant overall survival benefit was seen (median, 19 vs. 18 months resp.). Progressive disease was seen in 86 patients: in 37 patients in the CAI/RT group, and in 49 patients in the observation group (log-rank P < 0.02). Subgroup analysis showed significantly less liver metastases after adjuvant treatment in periampullary tumors (log-rank P < 0.03) without effect on local recurrence. Nonetheless, there was no significant effect on overall survival in these patients (log-rank P = 0.15). In patients with pancreatic cancer, CAI/RT had no significant effect on local recurrence (log-rank P = 0.12) neither on the development of liver metastases (log-rank P = 0.76) and consequently, no effect on overall survival.

CONCLUSION

This adjuvant treatment schedule results in a prolonged time to progression. For periampullary tumors, CAI/RT induced a significant reduction in the development of liver metastases, with a possible effect on overall survival. Especially in these tumors, CAI/RT might prove beneficial in larger groups and further research is warranted.

Authors+Show Affiliations

Department of Surgery, Erasmus MC Rotterdam, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19092348

Citation

Morak, Marjolein J M., et al. "Adjuvant Intra-arterial Chemotherapy and Radiotherapy Versus Surgery Alone in Resectable Pancreatic and Periampullary Cancer: a Prospective Randomized Controlled Trial." Annals of Surgery, vol. 248, no. 6, 2008, pp. 1031-41.
Morak MJ, van der Gaast A, Incrocci L, et al. Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. Ann Surg. 2008;248(6):1031-41.
Morak, M. J., van der Gaast, A., Incrocci, L., van Dekken, H., Hermans, J. J., Jeekel, J., Hop, W. C., Kazemier, G., & van Eijck, C. H. (2008). Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. Annals of Surgery, 248(6), 1031-41. https://doi.org/10.1097/SLA.0b013e318190c53e
Morak MJ, et al. Adjuvant Intra-arterial Chemotherapy and Radiotherapy Versus Surgery Alone in Resectable Pancreatic and Periampullary Cancer: a Prospective Randomized Controlled Trial. Ann Surg. 2008;248(6):1031-41. PubMed PMID: 19092348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. AU - Morak,Marjolein J M, AU - van der Gaast,Ate, AU - Incrocci,Luca, AU - van Dekken,Herman, AU - Hermans,John J, AU - Jeekel,Johannes, AU - Hop,Wim C J, AU - Kazemier,Geert, AU - van Eijck,Casper H J, PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/1/14/medline SP - 1031 EP - 41 JF - Annals of surgery JO - Ann. Surg. VL - 248 IS - 6 N2 - BACKGROUND: Success of surgical treatment for pancreatic and periampullary cancer is often limited due to locoregional recurrence and/or the development of distant metastases. OBJECTIVE: The survival benefit of celiac axis infusion (CAI) and radiotherapy (RT) versus observation after resection of pancreatic or periampullary cancer was investigated. METHODS: In a randomized controlled trial, 120 consecutive patients with histopathologically proven pancreatic or periampullary cancer received either adjuvant treatment consisting of intra-arterial mitoxantrone, 5-FU, leucovorin, and cisplatinum in combination with 30 x 1.8 Gy radiotherapy (group A) or no adjuvant treatment (group B). Groups were stratified for tumor type (pancreatic vs. periampullary tumors). RESULTS: After surgery, 120 patients were randomized (59 patients in the treatment group, 61 in the observation group). The median follow-up was 17 months. No significant overall survival benefit was seen (median, 19 vs. 18 months resp.). Progressive disease was seen in 86 patients: in 37 patients in the CAI/RT group, and in 49 patients in the observation group (log-rank P < 0.02). Subgroup analysis showed significantly less liver metastases after adjuvant treatment in periampullary tumors (log-rank P < 0.03) without effect on local recurrence. Nonetheless, there was no significant effect on overall survival in these patients (log-rank P = 0.15). In patients with pancreatic cancer, CAI/RT had no significant effect on local recurrence (log-rank P = 0.12) neither on the development of liver metastases (log-rank P = 0.76) and consequently, no effect on overall survival. CONCLUSION: This adjuvant treatment schedule results in a prolonged time to progression. For periampullary tumors, CAI/RT induced a significant reduction in the development of liver metastases, with a possible effect on overall survival. Especially in these tumors, CAI/RT might prove beneficial in larger groups and further research is warranted. SN - 1528-1140 UR - https://www.unboundmedicine.com/medline/citation/19092348/Adjuvant_intra_arterial_chemotherapy_and_radiotherapy_versus_surgery_alone_in_resectable_pancreatic_and_periampullary_cancer:_a_prospective_randomized_controlled_trial_ L2 - http://Insights.ovid.com/pubmed?pmid=19092348 DB - PRIME DP - Unbound Medicine ER -