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The utility of omega-3 fatty acids in cardiovascular disease.
Am J Ther 2009 Sep-Oct; 16(5):421-36AJ

Abstract

We reviewed the use of marine-derived omega-3 fatty acids in cardiovascular disease by discussing key epidemiologic and placebo-controlled studies in people with and without prior cardiovascular disease at baseline. In addition, studies on the antitriglyceridemic, antihypertensive, hemostatic, antiarrhythmic, and antiatherogenic properties of omega-3 fatty acids were examined. Lastly, we discussed current dietary and safety recommendations regarding fish and fish oil capsules as stated by the US Food and Drug Administration and the US Environmental Protection Agency. We found that omega-3 fatty acids have shown to significantly reduce coronary mortality and sudden death in people without prior cardiovascular disease and reduce all-cause death and cardiac mortality in secondary prevention studies. Studies on stroke are still unclear and more studies need to focus on stroke subtypes. The beneficial effects of omega-3 fatty acids might be the result of their ability to reduce triglyceride levels, blood pressure, platelet aggregation, arrhythmia, and atherogenesis. Currently, the general public is recommended to consume two fatty fish meals per week (0.3-0.5 grams per day eicosapentaenoic acid and docosahexaenoic acid). Pregnant mothers and children should refrain from eating fish high in methylmercury levels while limiting their consumption of other fish varieties to 12 ounces per week. Patients with coronary heart disease should have 1 g per day of eicosapentaenoic acid and docosahexaenoic acid, whereas patients with hypertriglyceridemia should take 3 to 5 g per day of eicosapentaenoic acid and docosahexaenoic acid under a physician's supervision.

Authors+Show Affiliations

Department of Medicine, Chicago Medical School, North Chicago, IL 60064, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19092647

Citation

Saremi, Adonis, and Rohit Arora. "The Utility of Omega-3 Fatty Acids in Cardiovascular Disease." American Journal of Therapeutics, vol. 16, no. 5, 2009, pp. 421-36.
Saremi A, Arora R. The utility of omega-3 fatty acids in cardiovascular disease. Am J Ther. 2009;16(5):421-36.
Saremi, A., & Arora, R. (2009). The utility of omega-3 fatty acids in cardiovascular disease. American Journal of Therapeutics, 16(5), pp. 421-36. doi:10.1097/MJT.0b013e3180a5f0bb.
Saremi A, Arora R. The Utility of Omega-3 Fatty Acids in Cardiovascular Disease. Am J Ther. 2009;16(5):421-36. PubMed PMID: 19092647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The utility of omega-3 fatty acids in cardiovascular disease. AU - Saremi,Adonis, AU - Arora,Rohit, PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2010/2/24/medline SP - 421 EP - 36 JF - American journal of therapeutics JO - Am J Ther VL - 16 IS - 5 N2 - We reviewed the use of marine-derived omega-3 fatty acids in cardiovascular disease by discussing key epidemiologic and placebo-controlled studies in people with and without prior cardiovascular disease at baseline. In addition, studies on the antitriglyceridemic, antihypertensive, hemostatic, antiarrhythmic, and antiatherogenic properties of omega-3 fatty acids were examined. Lastly, we discussed current dietary and safety recommendations regarding fish and fish oil capsules as stated by the US Food and Drug Administration and the US Environmental Protection Agency. We found that omega-3 fatty acids have shown to significantly reduce coronary mortality and sudden death in people without prior cardiovascular disease and reduce all-cause death and cardiac mortality in secondary prevention studies. Studies on stroke are still unclear and more studies need to focus on stroke subtypes. The beneficial effects of omega-3 fatty acids might be the result of their ability to reduce triglyceride levels, blood pressure, platelet aggregation, arrhythmia, and atherogenesis. Currently, the general public is recommended to consume two fatty fish meals per week (0.3-0.5 grams per day eicosapentaenoic acid and docosahexaenoic acid). Pregnant mothers and children should refrain from eating fish high in methylmercury levels while limiting their consumption of other fish varieties to 12 ounces per week. Patients with coronary heart disease should have 1 g per day of eicosapentaenoic acid and docosahexaenoic acid, whereas patients with hypertriglyceridemia should take 3 to 5 g per day of eicosapentaenoic acid and docosahexaenoic acid under a physician's supervision. SN - 1536-3686 UR - https://www.unboundmedicine.com/medline/citation/19092647/The_utility_of_omega_3_fatty_acids_in_cardiovascular_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=19092647.ui DB - PRIME DP - Unbound Medicine ER -