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Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects.
J ECT. 2009 Jun; 25(2):85-90.JE

Abstract

OBJECTIVES

To compare propofol and thiopental as anesthetic agents for electroconvulsive therapy (ECT) with respect to seizure duration, stimulus charge, clinical effect, and cognitive side effects.

METHODS

Randomized, blinded study of 62 depressed patients treated with bilateral ECT. Algorithm-based charge dosing was used.

RESULTS

The mean seizure duration of the patients in the thiopental group was 36.3 seconds versus 25.7 seconds in the propofol group (P = 0.001). The charge per treatment was 79.5 mC in the thiopental group versus 109.8 mC in the propofol group (P = 0.026). Sixteen patients in the propofol group (52%) reached the highest electrical dose versus 8 patients (26%) in the thiopental group (P = 0.014). No difference in response to treatment or number of treatments was observed. The mean score on Mini-Mental State Examination (MMSE) was 28.9 in the thiopental group versus 26.8 in the propofol group (P = 0.014). However, age distribution of patients completing the study differed between the groups.

CONCLUSIONS

Propofol significantly decreases seizure duration without significant difference in the clinical outcome. Using the employed treatment algorithm, patients anesthetised with propofol received higher electrical charge. Mini-Mental State Examination scores suggest that this results in more severe cognitive side effects. Results, however, might be confounded by the differences in age distribution in the groups.

Authors+Show Affiliations

Center of Psychiatry, Rigshospitalet, Copenhagen Ø, Denmark. jeanett.bauer@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19092676

Citation

Bauer, Jeanett, et al. "Comparison of Propofol and Thiopental as Anesthetic Agents for Electroconvulsive Therapy: a Randomized, Blinded Comparison of Seizure Duration, Stimulus Charge, Clinical Effect, and Cognitive Side Effects." The Journal of ECT, vol. 25, no. 2, 2009, pp. 85-90.
Bauer J, Hageman I, Dam H, et al. Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. J ECT. 2009;25(2):85-90.
Bauer, J., Hageman, I., Dam, H., Báez, A., Bolwig, T., Roed, J., Olsen, N. V., & Jørgensen, M. B. (2009). Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. The Journal of ECT, 25(2), 85-90. https://doi.org/10.1097/YCT.0b013e31818a0203
Bauer J, et al. Comparison of Propofol and Thiopental as Anesthetic Agents for Electroconvulsive Therapy: a Randomized, Blinded Comparison of Seizure Duration, Stimulus Charge, Clinical Effect, and Cognitive Side Effects. J ECT. 2009;25(2):85-90. PubMed PMID: 19092676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. AU - Bauer,Jeanett, AU - Hageman,Ida, AU - Dam,Henrik, AU - Báez,Armando, AU - Bolwig,Tom, AU - Roed,Jakob, AU - Olsen,Niels Vidiendal, AU - Jørgensen,Martin Balslev, PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/8/20/medline SP - 85 EP - 90 JF - The journal of ECT JO - J ECT VL - 25 IS - 2 N2 - OBJECTIVES: To compare propofol and thiopental as anesthetic agents for electroconvulsive therapy (ECT) with respect to seizure duration, stimulus charge, clinical effect, and cognitive side effects. METHODS: Randomized, blinded study of 62 depressed patients treated with bilateral ECT. Algorithm-based charge dosing was used. RESULTS: The mean seizure duration of the patients in the thiopental group was 36.3 seconds versus 25.7 seconds in the propofol group (P = 0.001). The charge per treatment was 79.5 mC in the thiopental group versus 109.8 mC in the propofol group (P = 0.026). Sixteen patients in the propofol group (52%) reached the highest electrical dose versus 8 patients (26%) in the thiopental group (P = 0.014). No difference in response to treatment or number of treatments was observed. The mean score on Mini-Mental State Examination (MMSE) was 28.9 in the thiopental group versus 26.8 in the propofol group (P = 0.014). However, age distribution of patients completing the study differed between the groups. CONCLUSIONS: Propofol significantly decreases seizure duration without significant difference in the clinical outcome. Using the employed treatment algorithm, patients anesthetised with propofol received higher electrical charge. Mini-Mental State Examination scores suggest that this results in more severe cognitive side effects. Results, however, might be confounded by the differences in age distribution in the groups. SN - 1533-4112 UR - https://www.unboundmedicine.com/medline/citation/19092676/Comparison_of_propofol_and_thiopental_as_anesthetic_agents_for_electroconvulsive_therapy:_a_randomized_blinded_comparison_of_seizure_duration_stimulus_charge_clinical_effect_and_cognitive_side_effects_ L2 - https://doi.org/10.1097/YCT.0b013e31818a0203 DB - PRIME DP - Unbound Medicine ER -