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Longitudinal changes in high molecular weight serum adiponectin levels in healthy infants.
Pediatr Res. 2009 Mar; 65(3):363-6.PR

Abstract

To determine the factors associated with high molecular weight adiponectin (HMW-ad) levels during the first year of life, the longitudinal changes in serum HMW-ad were investigated from birth to 12 mo of age. The total adiponectin levels, HMW-ad, and leptin were measured longitudinally from birth to 12 mo of age in 56 healthy infants (>or=35 wk of gestation). Serum HMW-ad levels were positively correlated with total adiponectin levels (R2 = 0.93, p < 0.0001). Serum HMW-ad levels at birth, six, and 12 mo were 13.7 +/- 0.9 (mean +/- SE), 13.3 +/- 0.8, and 7.7 +/- 0.5 microg/mL, respectively. The levels at 12 mo were significantly lower than those at birth and 6 mo, respectively. In a multiple regression analysis, the HMW-ad levels at 12 mo were found to be related only to cord blood HMW-ad levels (beta = 0.680, p < 0.001) and not to any other factors. These results imply that postnatal production of HMW-ad at least during infancy may be regulated before birth. Further study is necessary to determine whether cord blood HMW-ad has an effect and whether it is involved in the development of metabolic syndrome.

Authors+Show Affiliations

Department of Pediatrics, Showa University School of Medicine, Tokyo 142-8666, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19092724

Citation

Hibino, Satoshi, et al. "Longitudinal Changes in High Molecular Weight Serum Adiponectin Levels in Healthy Infants." Pediatric Research, vol. 65, no. 3, 2009, pp. 363-6.
Hibino S, Itabashi K, Nakano Y, et al. Longitudinal changes in high molecular weight serum adiponectin levels in healthy infants. Pediatr Res. 2009;65(3):363-6.
Hibino, S., Itabashi, K., Nakano, Y., Inoue, M., Tanaka, D., & Maruyama, T. (2009). Longitudinal changes in high molecular weight serum adiponectin levels in healthy infants. Pediatric Research, 65(3), 363-6. https://doi.org/10.1203/01.pdr.0000346538.23979.19
Hibino S, et al. Longitudinal Changes in High Molecular Weight Serum Adiponectin Levels in Healthy Infants. Pediatr Res. 2009;65(3):363-6. PubMed PMID: 19092724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal changes in high molecular weight serum adiponectin levels in healthy infants. AU - Hibino,Satoshi, AU - Itabashi,Kazuo, AU - Nakano,Yuya, AU - Inoue,Makoto, AU - Tanaka,Daisuke, AU - Maruyama,Takeshi, PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/6/17/medline SP - 363 EP - 6 JF - Pediatric research JO - Pediatr. Res. VL - 65 IS - 3 N2 - To determine the factors associated with high molecular weight adiponectin (HMW-ad) levels during the first year of life, the longitudinal changes in serum HMW-ad were investigated from birth to 12 mo of age. The total adiponectin levels, HMW-ad, and leptin were measured longitudinally from birth to 12 mo of age in 56 healthy infants (>or=35 wk of gestation). Serum HMW-ad levels were positively correlated with total adiponectin levels (R2 = 0.93, p < 0.0001). Serum HMW-ad levels at birth, six, and 12 mo were 13.7 +/- 0.9 (mean +/- SE), 13.3 +/- 0.8, and 7.7 +/- 0.5 microg/mL, respectively. The levels at 12 mo were significantly lower than those at birth and 6 mo, respectively. In a multiple regression analysis, the HMW-ad levels at 12 mo were found to be related only to cord blood HMW-ad levels (beta = 0.680, p < 0.001) and not to any other factors. These results imply that postnatal production of HMW-ad at least during infancy may be regulated before birth. Further study is necessary to determine whether cord blood HMW-ad has an effect and whether it is involved in the development of metabolic syndrome. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/19092724/Longitudinal_changes_in_high_molecular_weight_serum_adiponectin_levels_in_healthy_infants_ L2 - http://dx.doi.org/10.1203/PDR.0b013e3181973b3b DB - PRIME DP - Unbound Medicine ER -