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[Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study].
Eksp Klin Farmakol. 2008 Sep-Oct; 71(5):8-12.EK

Abstract

The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied. Significant interstrain differences in the content of norepinephrine (NE), dopamine (DA), serotonin (5-HT) as well as in the levels of their metabolites in hippocampus, hypothalamus, striatum and frontal cortex of C57Bl/6 and BALB/C mice were demonstrated. In particular, the content of 5-HT and its metabolite 5-oxyindolacetic acid (5-HIAA) in hippocampus of BALB/C mice (with passive stress response) was higher than in the same structure of C57Bl/6 (stress-susceptible) animals. The injection of selank (0.3 mg/kg) led to an increase in the NE level in the hypothalamus of both mice strains. At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DOPAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease. Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals. The obtained results are indicative of selectivity of the anxiolytic effects of selank.

Authors

Narkevich VB
No affiliation info available
Kudrin VS
No affiliation info available
Klodt PM
No affiliation info available
Pokrovskiĭ AA
No affiliation info available
Kozlovskaia MM
No affiliation info available
Maĭskiĭ AI
No affiliation info available
Raevskiĭ KS
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsBiogenic MonoaminesBrainBrain ChemistryHydroxyindoleacetic AcidMaleMiceMice, Inbred BALB COligopeptides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

rus

PubMed ID

19093364

Citation

Narkevich, V B., et al. "[Effects of Heptapeptide Selank On the Content of Monoamines and Their Metabolites in the Brain of BALB/C and C57Bl/6 Mice: a Comparative Study]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 71, no. 5, 2008, pp. 8-12.
Narkevich VB, Kudrin VS, Klodt PM, et al. [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. Eksp Klin Farmakol. 2008;71(5):8-12.
Narkevich, V. B., Kudrin, V. S., Klodt, P. M., Pokrovskiĭ, A. A., Kozlovskaia, M. M., Maĭskiĭ, A. I., & Raevskiĭ, K. S. (2008). [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. Eksperimental'naia I Klinicheskaia Farmakologiia, 71(5), 8-12.
Narkevich VB, et al. [Effects of Heptapeptide Selank On the Content of Monoamines and Their Metabolites in the Brain of BALB/C and C57Bl/6 Mice: a Comparative Study]. Eksp Klin Farmakol. 2008 Sep-Oct;71(5):8-12. PubMed PMID: 19093364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. AU - Narkevich,V B, AU - Kudrin,V S, AU - Klodt,P M, AU - Pokrovskiĭ,A A, AU - Kozlovskaia,M M, AU - Maĭskiĭ,A I, AU - Raevskiĭ,K S, PY - 2008/12/20/entrez PY - 2008/12/20/pubmed PY - 2009/2/4/medline SP - 8 EP - 12 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 71 IS - 5 N2 - The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied. Significant interstrain differences in the content of norepinephrine (NE), dopamine (DA), serotonin (5-HT) as well as in the levels of their metabolites in hippocampus, hypothalamus, striatum and frontal cortex of C57Bl/6 and BALB/C mice were demonstrated. In particular, the content of 5-HT and its metabolite 5-oxyindolacetic acid (5-HIAA) in hippocampus of BALB/C mice (with passive stress response) was higher than in the same structure of C57Bl/6 (stress-susceptible) animals. The injection of selank (0.3 mg/kg) led to an increase in the NE level in the hypothalamus of both mice strains. At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DOPAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease. Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals. The obtained results are indicative of selectivity of the anxiolytic effects of selank. SN - 0869-2092 UR - https://www.unboundmedicine.com/medline/citation/19093364/[Effects_of_heptapeptide_selank_on_the_content_of_monoamines_and_their_metabolites_in_the_brain_of_BALB/C_and_C57Bl/6_mice:_a_comparative_study]_ DB - PRIME DP - Unbound Medicine ER -