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Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease.
J Med Chem. 2009 Jan 22; 52(2):559-63.JM

Abstract

A series of multifunctional codrugs (1-6) were synthesized to overcome the pro-oxidant effect associated with L-dopa (LD) therapy. Target compounds release LD and dopamine (DA) in human plasma after enzymatic hydrolysis, displaying an antioxidant effect superior to that of N-acetylcysteine (NAC). After intracerebroventricular injection of codrug 4, the levels of DA in the striatum were higher than those in LD-treated groups, indicating that this compound has a longer half-life in brain than LD.

Authors+Show Affiliations

Dipartimento di Scienze del Farmaco, Universita G. D'Annunzio, Via dei Vestini 31, 66100 Chieti, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19093882

Citation

Pinnen, Francesco, et al. "Codrugs Linking L-dopa and Sulfur-containing Antioxidants: New Pharmacological Tools Against Parkinson's Disease." Journal of Medicinal Chemistry, vol. 52, no. 2, 2009, pp. 559-63.
Pinnen F, Cacciatore I, Cornacchia C, et al. Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease. J Med Chem. 2009;52(2):559-63.
Pinnen, F., Cacciatore, I., Cornacchia, C., Sozio, P., Cerasa, L. S., Iannitelli, A., Nasuti, C., Cantalamessa, F., Sekar, D., Gabbianelli, R., Falcioni, M. L., & Di Stefano, A. (2009). Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease. Journal of Medicinal Chemistry, 52(2), 559-63. https://doi.org/10.1021/jm801266x
Pinnen F, et al. Codrugs Linking L-dopa and Sulfur-containing Antioxidants: New Pharmacological Tools Against Parkinson's Disease. J Med Chem. 2009 Jan 22;52(2):559-63. PubMed PMID: 19093882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease. AU - Pinnen,Francesco, AU - Cacciatore,Ivana, AU - Cornacchia,Catia, AU - Sozio,Piera, AU - Cerasa,Laura Serafina, AU - Iannitelli,Antonio, AU - Nasuti,Cinzia, AU - Cantalamessa,Franco, AU - Sekar,Durairaj, AU - Gabbianelli,Rosita, AU - Falcioni,Maria Letizia, AU - Di Stefano,Antonio, PY - 2008/12/20/entrez PY - 2008/12/20/pubmed PY - 2009/2/24/medline SP - 559 EP - 63 JF - Journal of medicinal chemistry JO - J Med Chem VL - 52 IS - 2 N2 - A series of multifunctional codrugs (1-6) were synthesized to overcome the pro-oxidant effect associated with L-dopa (LD) therapy. Target compounds release LD and dopamine (DA) in human plasma after enzymatic hydrolysis, displaying an antioxidant effect superior to that of N-acetylcysteine (NAC). After intracerebroventricular injection of codrug 4, the levels of DA in the striatum were higher than those in LD-treated groups, indicating that this compound has a longer half-life in brain than LD. SN - 1520-4804 UR - https://www.unboundmedicine.com/medline/citation/19093882/Codrugs_linking_L_dopa_and_sulfur_containing_antioxidants:_new_pharmacological_tools_against_Parkinson's_disease_ L2 - https://doi.org/10.1021/jm801266x DB - PRIME DP - Unbound Medicine ER -