Tags

Type your tag names separated by a space and hit enter

Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome?
Clin Endocrinol (Oxf). 2009 Sep; 71(3):406-11.CE

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is associated with adverse metabolic effects. Some cardiovascular disease (CVD) risk markers are increased in women with PCOS. However, early markers of atherosclerosis are also associated with obesity and insulin resistance, which are related to PCOS. These markers may result either directly from PCOS or indirectly as a consequence of the comorbidities associated with the syndrome.

CONTEXT

To assess the presence of early CVD markers in young, nonobese women with PCOS.

PATIENTS

Forty women with PCOS and 50 healthy women with regular menstrual cycles, matched for age and body mass index (BMI).

MEASUREMENTS

The following CVD markers were assessed by ultrasonography: common carotid artery (CCA) stiffness index (beta), distensibility and intima-media thickness (IMT), and brachial artery flow-mediated dilatation (FMD). Inflammatory markers, including interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, homocysteine, C-reactive protein (CRP), glycaemia, lipid profile and insulin, were also assessed.

RESULTS

CCA beta was higher in PCOS than in control women (3.72 +/- 0.96 vs. 3.36 +/- 0.96, P = 0.04) and CCA distensibility was lower (0.31 +/- 0.08 vs. 0.35 +/- 0.09 mmHg(-1), P = 0.02). Waist circumference, total testosterone and the Free Androgen Index (FAI) were higher in PCOS patients than in controls (78.2 +/- 10.0 vs. 71.5 +/- 7.2 cm, P = 0.001; 88.1 +/- 32.4 vs. 57.1 +/- 21.2 ng/dl, P < 0.01; 12.7 +/- 15.7%vs. 4.7 +/- 2.3%, P < 0.01, respectively), while SHBG was reduced (37.9 +/- 19.1 vs. 47.8 +/- 18.3 nmol/l, P = 0.01). The remaining variables did not differ between the groups.

CONCLUSIONS

Young women with PCOS exhibit changes in vascular elasticity even in the absence of classical risk factors for CVD, such as hypertension and obesity.

Links

Aggregator Full Text

Authors+Show Affiliations

Soares GM
Department of Gynaecology and Obstetrics at the University of São Paulo, Ribeirão Preto School of Medicine, Ribeirão Preto, Brazil.
Vieira CS
No affiliation info available
Martins WP
No affiliation info available
Franceschini SA
No affiliation info available
dos Reis RM
No affiliation info available
Silva de Sá MF
No affiliation info available
Ferriani RA
No affiliation info available

MeSH

AdultCarotid ArteriesCross-Sectional StudiesFemaleHumansInterleukin-6MorbidityPolycystic Ovary SyndromeTumor Necrosis Factor-alphaUltrasonographyYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19094071

Citation

Soares, Gustavo Mafaldo, et al. "Increased Arterial Stiffness in Nonobese Women With Polycystic Ovary Syndrome (PCOS) Without Comorbidities: One More Characteristic Inherent to the Syndrome?" Clinical Endocrinology, vol. 71, no. 3, 2009, pp. 406-11.
Soares GM, Vieira CS, Martins WP, et al. Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? Clin Endocrinol (Oxf). 2009;71(3):406-11.
Soares, G. M., Vieira, C. S., Martins, W. P., Franceschini, S. A., dos Reis, R. M., Silva de Sá, M. F., & Ferriani, R. A. (2009). Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? Clinical Endocrinology, 71(3), 406-11. https://doi.org/10.1111/j.1365-2265.2008.03506.x
Soares GM, et al. Increased Arterial Stiffness in Nonobese Women With Polycystic Ovary Syndrome (PCOS) Without Comorbidities: One More Characteristic Inherent to the Syndrome. Clin Endocrinol (Oxf). 2009;71(3):406-11. PubMed PMID: 19094071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome? AU - Soares,Gustavo Mafaldo, AU - Vieira,Carolina Sales, AU - Martins,Wellington Paula, AU - Franceschini,Sílvio Antônio, AU - dos Reis,Rosana Maria, AU - Silva de Sá,Marcos Felipe, AU - Ferriani,Rui Alberto, Y1 - 2008/12/15/ PY - 2008/12/20/entrez PY - 2008/12/20/pubmed PY - 2009/10/20/medline SP - 406 EP - 11 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 71 IS - 3 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with adverse metabolic effects. Some cardiovascular disease (CVD) risk markers are increased in women with PCOS. However, early markers of atherosclerosis are also associated with obesity and insulin resistance, which are related to PCOS. These markers may result either directly from PCOS or indirectly as a consequence of the comorbidities associated with the syndrome. CONTEXT: To assess the presence of early CVD markers in young, nonobese women with PCOS. PATIENTS: Forty women with PCOS and 50 healthy women with regular menstrual cycles, matched for age and body mass index (BMI). MEASUREMENTS: The following CVD markers were assessed by ultrasonography: common carotid artery (CCA) stiffness index (beta), distensibility and intima-media thickness (IMT), and brachial artery flow-mediated dilatation (FMD). Inflammatory markers, including interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, homocysteine, C-reactive protein (CRP), glycaemia, lipid profile and insulin, were also assessed. RESULTS: CCA beta was higher in PCOS than in control women (3.72 +/- 0.96 vs. 3.36 +/- 0.96, P = 0.04) and CCA distensibility was lower (0.31 +/- 0.08 vs. 0.35 +/- 0.09 mmHg(-1), P = 0.02). Waist circumference, total testosterone and the Free Androgen Index (FAI) were higher in PCOS patients than in controls (78.2 +/- 10.0 vs. 71.5 +/- 7.2 cm, P = 0.001; 88.1 +/- 32.4 vs. 57.1 +/- 21.2 ng/dl, P < 0.01; 12.7 +/- 15.7%vs. 4.7 +/- 2.3%, P < 0.01, respectively), while SHBG was reduced (37.9 +/- 19.1 vs. 47.8 +/- 18.3 nmol/l, P = 0.01). The remaining variables did not differ between the groups. CONCLUSIONS: Young women with PCOS exhibit changes in vascular elasticity even in the absence of classical risk factors for CVD, such as hypertension and obesity. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/19094071/Increased_arterial_stiffness_in_nonobese_women_with_polycystic_ovary_syndrome__PCOS__without_comorbidities:_one_more_characteristic_inherent_to_the_syndrome L2 - https://doi.org/10.1111/j.1365-2265.2008.03506.x DB - PRIME DP - Unbound Medicine ER -