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Reactivity to autologous serum skin test and relationship with complement levels in chronic idiopathic urticaria and angio-oedema.
Clin Exp Dermatol. 2009 Jul; 34(5):587-90.CE

Abstract

BACKGROUND

A role for complement in autoantibody-mediated histamine release in urticaria has been suggested but not proven in vivo. Aim. To study serum complement levels in patients with chronic idiopathic urticaria (CIU) and to determine whether there was a relationship with autologous serum skin test (ASST) reactivity.

METHODS

We recruited 35 patients with CIU. Complement (C3, C4) levels and ASST were measured in all patients; additional investigations were undertaken dependent on history and examination.

RESULTS

Complement concentrations were outside the population reference intervals in 19/35 patients, with low C3 noted in 3/35 and low C4 in 18/35. Of 12 patients with a positive ASST, 7 had low complement levels, and 12/23 with a negative ASST had low complement levels. Patients with a positive ASST had a median C3 of 1.24 g/L (range 0.35-1.51) compared with a median of 1.25 g/L in those with a negative ASST (P = 0.36), and a median C4 of 0.20 g/L (range 0.185-0.452) in those with a positive ASST compared with 0.18 g/L in those with a negative ASST (P = 0.88).

CONCLUSIONS

We conclude that both a reduction in C4 and positive ASST are common in CIU and although these immunological abnormalities often coexist, there is no clear relationship between them. Other components of the complement system may be worth exploring.

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Authors+Show Affiliations

Zamiri M
Dermatology, Monklands Hospital, Airdrie, UK. m.zamiri@clinmed.gla.ac.uk
Jury CS
No affiliation info available
Dawe RS
No affiliation info available
O'Neill S
No affiliation info available
Douglas WS
No affiliation info available

MeSH

AdolescentAdultAgedAngioedemaComplement C3Complement C4Complement System ProteinsFemaleHumansMaleMiddle AgedSkin TestsUrticariaYoung Adult

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

19094131

Citation

Zamiri, M, et al. "Reactivity to Autologous Serum Skin Test and Relationship With Complement Levels in Chronic Idiopathic Urticaria and Angio-oedema." Clinical and Experimental Dermatology, vol. 34, no. 5, 2009, pp. 587-90.
Zamiri M, Jury CS, Dawe RS, et al. Reactivity to autologous serum skin test and relationship with complement levels in chronic idiopathic urticaria and angio-oedema. Clin Exp Dermatol. 2009;34(5):587-90.
Zamiri, M., Jury, C. S., Dawe, R. S., O'Neill, S., & Douglas, W. S. (2009). Reactivity to autologous serum skin test and relationship with complement levels in chronic idiopathic urticaria and angio-oedema. Clinical and Experimental Dermatology, 34(5), 587-90. https://doi.org/10.1111/j.1365-2230.2008.03032.x
Zamiri M, et al. Reactivity to Autologous Serum Skin Test and Relationship With Complement Levels in Chronic Idiopathic Urticaria and Angio-oedema. Clin Exp Dermatol. 2009;34(5):587-90. PubMed PMID: 19094131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactivity to autologous serum skin test and relationship with complement levels in chronic idiopathic urticaria and angio-oedema. AU - Zamiri,M, AU - Jury,C S, AU - Dawe,R S, AU - O'Neill,S, AU - Douglas,W S, Y1 - 2008/12/15/ PY - 2008/12/20/entrez PY - 2008/12/20/pubmed PY - 2009/7/28/medline SP - 587 EP - 90 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 34 IS - 5 N2 - BACKGROUND: A role for complement in autoantibody-mediated histamine release in urticaria has been suggested but not proven in vivo. Aim. To study serum complement levels in patients with chronic idiopathic urticaria (CIU) and to determine whether there was a relationship with autologous serum skin test (ASST) reactivity. METHODS: We recruited 35 patients with CIU. Complement (C3, C4) levels and ASST were measured in all patients; additional investigations were undertaken dependent on history and examination. RESULTS: Complement concentrations were outside the population reference intervals in 19/35 patients, with low C3 noted in 3/35 and low C4 in 18/35. Of 12 patients with a positive ASST, 7 had low complement levels, and 12/23 with a negative ASST had low complement levels. Patients with a positive ASST had a median C3 of 1.24 g/L (range 0.35-1.51) compared with a median of 1.25 g/L in those with a negative ASST (P = 0.36), and a median C4 of 0.20 g/L (range 0.185-0.452) in those with a positive ASST compared with 0.18 g/L in those with a negative ASST (P = 0.88). CONCLUSIONS: We conclude that both a reduction in C4 and positive ASST are common in CIU and although these immunological abnormalities often coexist, there is no clear relationship between them. Other components of the complement system may be worth exploring. SN - 1365-2230 UR - https://www.unboundmedicine.com/medline/citation/19094131/Reactivity_to_autologous_serum_skin_test_and_relationship_with_complement_levels_in_chronic_idiopathic_urticaria_and_angio_oedema_ L2 - https://doi.org/10.1111/j.1365-2230.2008.03032.x DB - PRIME DP - Unbound Medicine ER -