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Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI.

Abstract

PURPOSE

To determine which MR technique was the most sensitive to age-related white matter damage. We compared both diffusion tensor imaging (DTI) and magnetization transfer (MT) maps to determine which technique correlated most strongly with cognitive function in a middle-aged and elderly community population.

MATERIALS AND METHODS

In all, 64 healthy subjects (aged 50-90) underwent MRI and neuropsychology. Histograms were generated for white matter mean diffusivity (MD), fractional anisotropy (FA), and MT ratio (MTR). White matter hyperintensity volume (WMH) and brain volume were also determined. Composite neuropsychological scores were derived for 4 cognitive domains (executive function, working memory, episodic memory, and information processing speed).

RESULTS

All MRI parameters correlated with age (FA r = 0.726, P < 0.001; MD r = -0.619 P < 0.001, MTR r = -0.566, P < 0.001, WMH r = 0.511, P < 0.001). All MRI parameters correlated with cognition, but DTI, and particularly FA, correlated most strongly. Adding DTI parameters explained more variance in cognition than WMH alone; the increase was greatest with FA, which alone explained 45%, 33%, and 25% of the variance in cognition for information processing speed, episodic memory, and executive function, respectively.

CONCLUSION

DTI appears the most sensitive imaging parameter to determine age-related white matter damage. The stronger relationship with FA suggests that axonal damage is important in age-related cognitive decline.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Neuroscience, St George's University of London, UK. p0505740@sgul.ac.uk

    , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Algorithms
    Brain
    Cognition Disorders
    Demyelinating Diseases
    Diffusion Magnetic Resonance Imaging
    Female
    Humans
    Image Enhancement
    Image Interpretation, Computer-Assisted
    Male
    Middle Aged
    Nerve Fibers, Myelinated
    Reproducibility of Results
    Sensitivity and Specificity

    Pub Type(s)

    Evaluation Studies
    Journal Article

    Language

    eng

    PubMed ID

    19097099

    Citation

    Schiavone, Francesca, et al. "Imaging Age-related Cognitive Decline: a Comparison of Diffusion Tensor and Magnetization Transfer MRI." Journal of Magnetic Resonance Imaging : JMRI, vol. 29, no. 1, 2009, pp. 23-30.
    Schiavone F, Charlton RA, Barrick TR, et al. Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI. J Magn Reson Imaging. 2009;29(1):23-30.
    Schiavone, F., Charlton, R. A., Barrick, T. R., Morris, R. G., & Markus, H. S. (2009). Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI. Journal of Magnetic Resonance Imaging : JMRI, 29(1), pp. 23-30. doi:10.1002/jmri.21572.
    Schiavone F, et al. Imaging Age-related Cognitive Decline: a Comparison of Diffusion Tensor and Magnetization Transfer MRI. J Magn Reson Imaging. 2009;29(1):23-30. PubMed PMID: 19097099.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI. AU - Schiavone,Francesca, AU - Charlton,Rebecca Ann, AU - Barrick,Thomas Richard, AU - Morris,Robin Guy, AU - Markus,Hugh Stephen, PY - 2008/12/20/entrez PY - 2008/12/20/pubmed PY - 2009/2/20/medline SP - 23 EP - 30 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 29 IS - 1 N2 - PURPOSE: To determine which MR technique was the most sensitive to age-related white matter damage. We compared both diffusion tensor imaging (DTI) and magnetization transfer (MT) maps to determine which technique correlated most strongly with cognitive function in a middle-aged and elderly community population. MATERIALS AND METHODS: In all, 64 healthy subjects (aged 50-90) underwent MRI and neuropsychology. Histograms were generated for white matter mean diffusivity (MD), fractional anisotropy (FA), and MT ratio (MTR). White matter hyperintensity volume (WMH) and brain volume were also determined. Composite neuropsychological scores were derived for 4 cognitive domains (executive function, working memory, episodic memory, and information processing speed). RESULTS: All MRI parameters correlated with age (FA r = 0.726, P < 0.001; MD r = -0.619 P < 0.001, MTR r = -0.566, P < 0.001, WMH r = 0.511, P < 0.001). All MRI parameters correlated with cognition, but DTI, and particularly FA, correlated most strongly. Adding DTI parameters explained more variance in cognition than WMH alone; the increase was greatest with FA, which alone explained 45%, 33%, and 25% of the variance in cognition for information processing speed, episodic memory, and executive function, respectively. CONCLUSION: DTI appears the most sensitive imaging parameter to determine age-related white matter damage. The stronger relationship with FA suggests that axonal damage is important in age-related cognitive decline. SN - 1053-1807 UR - https://www.unboundmedicine.com/medline/citation/19097099/Imaging_age_related_cognitive_decline:_A_comparison_of_diffusion_tensor_and_magnetization_transfer_MRI_ L2 - https://doi.org/10.1002/jmri.21572 DB - PRIME DP - Unbound Medicine ER -