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Clostridium difficile infections in a Shanghai hospital: antimicrobial resistance, toxin profiles and ribotypes.
Int J Antimicrob Agents. 2009 Apr; 33(4):339-42.IJ

Abstract

The incidence of Clostridium difficile infection (CDI) has risen markedly since 2003, however data from China are limited. A 1-year study was conducted at the University Hospital Huashan to characterise clinical isolates of C. difficile. Of 74 isolates, 56 were from the first episode of CDI (43 A(+)B(+) and 13 A(-)B(+)), 5 were from recurrences and 13 were toxin-negative. No binary toxin or TcdC deletion was detected. All strains were susceptible to metronidazole, vancomycin, meropenem and piperacillin/tazobactam. Resistance to moxifloxacin, ciprofloxacin, levofloxacin, erythromycin, clindamycin, tetracycline, rifampicin and fusidic acid was found in 46.4%, 100%, 60.7%, 71.4%, 71.4%, 35.7%, 25.0% and 17.9% of the isolates, respectively. All moxifloxacin-resistant isolates carried a mutation in either gyrA, gyrB or both. Fourteen different polymerase chain reaction ribotypes were identified, with a specific clone (SH II) accounting for 25% of isolates. No isolates belonged to ribotype 027. The present study is the first systematic survey of clinical C. difficile isolates in China. Further surveillance is required to detect clustering of cases and to monitor the emergence of specific highly virulent clones and resistance.

Authors+Show Affiliations

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19097757

Citation

Huang, Haihui, et al. "Clostridium Difficile Infections in a Shanghai Hospital: Antimicrobial Resistance, Toxin Profiles and Ribotypes." International Journal of Antimicrobial Agents, vol. 33, no. 4, 2009, pp. 339-42.
Huang H, Wu S, Wang M, et al. Clostridium difficile infections in a Shanghai hospital: antimicrobial resistance, toxin profiles and ribotypes. Int J Antimicrob Agents. 2009;33(4):339-42.
Huang, H., Wu, S., Wang, M., Zhang, Y., Fang, H., Palmgren, A. C., Weintraub, A., & Nord, C. E. (2009). Clostridium difficile infections in a Shanghai hospital: antimicrobial resistance, toxin profiles and ribotypes. International Journal of Antimicrobial Agents, 33(4), 339-42. https://doi.org/10.1016/j.ijantimicag.2008.09.022
Huang H, et al. Clostridium Difficile Infections in a Shanghai Hospital: Antimicrobial Resistance, Toxin Profiles and Ribotypes. Int J Antimicrob Agents. 2009;33(4):339-42. PubMed PMID: 19097757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clostridium difficile infections in a Shanghai hospital: antimicrobial resistance, toxin profiles and ribotypes. AU - Huang,Haihui, AU - Wu,Shi, AU - Wang,Minggui, AU - Zhang,Yingyuan, AU - Fang,Hong, AU - Palmgren,Ann-Chatrin, AU - Weintraub,Andrej, AU - Nord,Carl Erik, Y1 - 2008/12/20/ PY - 2008/09/26/received PY - 2008/09/26/accepted PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/5/2/medline SP - 339 EP - 42 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 33 IS - 4 N2 - The incidence of Clostridium difficile infection (CDI) has risen markedly since 2003, however data from China are limited. A 1-year study was conducted at the University Hospital Huashan to characterise clinical isolates of C. difficile. Of 74 isolates, 56 were from the first episode of CDI (43 A(+)B(+) and 13 A(-)B(+)), 5 were from recurrences and 13 were toxin-negative. No binary toxin or TcdC deletion was detected. All strains were susceptible to metronidazole, vancomycin, meropenem and piperacillin/tazobactam. Resistance to moxifloxacin, ciprofloxacin, levofloxacin, erythromycin, clindamycin, tetracycline, rifampicin and fusidic acid was found in 46.4%, 100%, 60.7%, 71.4%, 71.4%, 35.7%, 25.0% and 17.9% of the isolates, respectively. All moxifloxacin-resistant isolates carried a mutation in either gyrA, gyrB or both. Fourteen different polymerase chain reaction ribotypes were identified, with a specific clone (SH II) accounting for 25% of isolates. No isolates belonged to ribotype 027. The present study is the first systematic survey of clinical C. difficile isolates in China. Further surveillance is required to detect clustering of cases and to monitor the emergence of specific highly virulent clones and resistance. SN - 1872-7913 UR - https://www.unboundmedicine.com/medline/citation/19097757/Clostridium_difficile_infections_in_a_Shanghai_hospital:_antimicrobial_resistance_toxin_profiles_and_ribotypes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(08)00480-9 DB - PRIME DP - Unbound Medicine ER -