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Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats.
Nutrition. 2009 May; 25(5):567-73.N

Abstract

OBJECTIVE

Normal aging in animals and humans is accompanied by a decline in cognitive performance that is thought to be due to the long-term effects of oxidative stress and inflammation on neurologic processes. Previous findings have suggested that protection against age-related cognitive declines may be achieved by increasing the dietary intake of fruits and vegetables, especially those that are high in antioxidant activity, such as blueberries and strawberries. The objective of this study was to investigate supplementation with Prunus domestica L. in mitigating age-related deficits in cognitive function.

METHODS

We investigated the effects of supplementation with P. domestica L., consumed as a 2% dried plum (i.e., prune) powder or 100% plum juice for 8 wk, in mitigating age-related deficits in cognitive function in aged Fischer 344 rats.

RESULTS

Rats that drank plum juice from 19 to 21 mo of age had improved working memory in the Morris water maze, whereas rats fed dried plum powder were not different from the control group, possibly due to the smaller quantity of phenolics consumed in the powder group compared with the juice group.

CONCLUSION

These results are discussed in relation to the amount and type of phenolics present in the plum products and in relation to other dietary intervention studies in which cognitive benefits have been reported.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA. barbara.shukitthale@ars.usda.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19097856

Citation

Shukitt-Hale, Barbara, et al. "Plum Juice, but Not Dried Plum Powder, Is Effective in Mitigating Cognitive Deficits in Aged Rats." Nutrition (Burbank, Los Angeles County, Calif.), vol. 25, no. 5, 2009, pp. 567-73.
Shukitt-Hale B, Kalt W, Carey AN, et al. Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats. Nutrition. 2009;25(5):567-73.
Shukitt-Hale, B., Kalt, W., Carey, A. N., Vinqvist-Tymchuk, M., McDonald, J., & Joseph, J. A. (2009). Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats. Nutrition (Burbank, Los Angeles County, Calif.), 25(5), 567-73. https://doi.org/10.1016/j.nut.2008.10.018
Shukitt-Hale B, et al. Plum Juice, but Not Dried Plum Powder, Is Effective in Mitigating Cognitive Deficits in Aged Rats. Nutrition. 2009;25(5):567-73. PubMed PMID: 19097856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats. AU - Shukitt-Hale,Barbara, AU - Kalt,Wilhelmina, AU - Carey,Amanda N, AU - Vinqvist-Tymchuk,Melinda, AU - McDonald,Jane, AU - Joseph,James A, Y1 - 2008/12/18/ PY - 2008/07/28/received PY - 2008/10/14/revised PY - 2008/10/26/accepted PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/6/26/medline SP - 567 EP - 73 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 25 IS - 5 N2 - OBJECTIVE: Normal aging in animals and humans is accompanied by a decline in cognitive performance that is thought to be due to the long-term effects of oxidative stress and inflammation on neurologic processes. Previous findings have suggested that protection against age-related cognitive declines may be achieved by increasing the dietary intake of fruits and vegetables, especially those that are high in antioxidant activity, such as blueberries and strawberries. The objective of this study was to investigate supplementation with Prunus domestica L. in mitigating age-related deficits in cognitive function. METHODS: We investigated the effects of supplementation with P. domestica L., consumed as a 2% dried plum (i.e., prune) powder or 100% plum juice for 8 wk, in mitigating age-related deficits in cognitive function in aged Fischer 344 rats. RESULTS: Rats that drank plum juice from 19 to 21 mo of age had improved working memory in the Morris water maze, whereas rats fed dried plum powder were not different from the control group, possibly due to the smaller quantity of phenolics consumed in the powder group compared with the juice group. CONCLUSION: These results are discussed in relation to the amount and type of phenolics present in the plum products and in relation to other dietary intervention studies in which cognitive benefits have been reported. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19097856/Plum_juice_but_not_dried_plum_powder_is_effective_in_mitigating_cognitive_deficits_in_aged_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00449-8 DB - PRIME DP - Unbound Medicine ER -