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Does reversal of oxidative stress and inflammation provide vascular protection?
Cardiovasc Res 2009; 81(4):649-59CR

Abstract

Chronic inflammation is a pathogenic feature of atherosclerosis and cardiovascular disease mediated by substances including angiotensin II, proinflammatory cytokines, and free fatty acids. This promotes generation of reactive oxygen species in vascular endothelial cells and smooth muscle cells, which mediate injury through several mechanisms. Reciprocal relationships between endothelial dysfunction and insulin resistance as well as cross-talk between hyperlipidaemia and the renin-angiotensin-aldosterone system (RAAS) at multiple levels contribute importantly to a variety of risk factors. Therefore, combination therapy that simultaneously addresses multiple mechanisms for the pathogenesis of atherosclerosis is an attractive emerging concept for slowing progression of atherosclerosis. Combined therapy with statins, peroxisome proliferator-activated receptors, and RAAS blockade demonstrates additive beneficial effects on endothelial dysfunction and insulin resistance when compared with monotherapies in patients with cardiovascular risk factors due to both distinct and interrelated mechanisms. These additive beneficial effects of combined therapies are consistent with laboratory and recent clinical studies. Thus, combination therapy may be an important paradigm for treating and slowing progression of atherosclerosis, coronary heart disease, and co-morbid metabolic disorders characterized by endothelial dysfunction and insulin resistance.

Authors+Show Affiliations

Vascular Medicine and Atherosclerosis Unit, Division of Cardiology, Gachon University, Gil Medical Center, 1198 Kuwol-dong, Namdong-gu, Incheon 405-760, South Korea. kwangk@gilhospital.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19098298

Citation

Koh, Kwang Kon, et al. "Does Reversal of Oxidative Stress and Inflammation Provide Vascular Protection?" Cardiovascular Research, vol. 81, no. 4, 2009, pp. 649-59.
Koh KK, Oh PC, Quon MJ. Does reversal of oxidative stress and inflammation provide vascular protection? Cardiovasc Res. 2009;81(4):649-59.
Koh, K. K., Oh, P. C., & Quon, M. J. (2009). Does reversal of oxidative stress and inflammation provide vascular protection? Cardiovascular Research, 81(4), pp. 649-59. doi:10.1093/cvr/cvn354.
Koh KK, Oh PC, Quon MJ. Does Reversal of Oxidative Stress and Inflammation Provide Vascular Protection. Cardiovasc Res. 2009 Mar 1;81(4):649-59. PubMed PMID: 19098298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does reversal of oxidative stress and inflammation provide vascular protection? AU - Koh,Kwang Kon, AU - Oh,Pyung Chun, AU - Quon,Michael J, Y1 - 2008/12/20/ PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/6/12/medline SP - 649 EP - 59 JF - Cardiovascular research JO - Cardiovasc. Res. VL - 81 IS - 4 N2 - Chronic inflammation is a pathogenic feature of atherosclerosis and cardiovascular disease mediated by substances including angiotensin II, proinflammatory cytokines, and free fatty acids. This promotes generation of reactive oxygen species in vascular endothelial cells and smooth muscle cells, which mediate injury through several mechanisms. Reciprocal relationships between endothelial dysfunction and insulin resistance as well as cross-talk between hyperlipidaemia and the renin-angiotensin-aldosterone system (RAAS) at multiple levels contribute importantly to a variety of risk factors. Therefore, combination therapy that simultaneously addresses multiple mechanisms for the pathogenesis of atherosclerosis is an attractive emerging concept for slowing progression of atherosclerosis. Combined therapy with statins, peroxisome proliferator-activated receptors, and RAAS blockade demonstrates additive beneficial effects on endothelial dysfunction and insulin resistance when compared with monotherapies in patients with cardiovascular risk factors due to both distinct and interrelated mechanisms. These additive beneficial effects of combined therapies are consistent with laboratory and recent clinical studies. Thus, combination therapy may be an important paradigm for treating and slowing progression of atherosclerosis, coronary heart disease, and co-morbid metabolic disorders characterized by endothelial dysfunction and insulin resistance. SN - 1755-3245 UR - https://www.unboundmedicine.com/medline/citation/19098298/Does_reversal_of_oxidative_stress_and_inflammation_provide_vascular_protection L2 - https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvn354 DB - PRIME DP - Unbound Medicine ER -