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The histologic spectrum of liver disease in African-American, non-Hispanic white, and Hispanic obesity surgery patients.
Am J Gastroenterol. 2009 Jan; 104(1):64-9.AJ

Abstract

OBJECTIVES

Non-alcoholic fatty liver disease (NAFLD) is a prominent cause of chronic liver disease in African Americans, non-Hispanic whites, and Hispanics. The aim of this study was to evaluate ethnic differences in the prevalence of NAFLD and non-alcoholic steatohepatitis (NASH) and to compare the severity of histologic features of NASH in obesity surgery patients.

METHODS

Subjects consisted of 238 patients who had a routine liver biopsy at the time of obesity surgery. Demographic and clinical variables pertaining to the metabolic syndrome were collected retrospectively. Liver biopsies were evaluated according to the scoring system proposed by the Nonalcoholic Steatohepatitis Clinical Research Network and NASH was defined as a NASH activity score > or =5.

RESULTS

African Americans had lower rates of steatosis than non-Hispanic whites (P<0.001) and Hispanics (P=0.03). Among patients with steatosis, African Americans had lower rates of NASH than non-Hispanic whites (P=0.05) and Hispanics (P=0.02) and lower rates of fibrosis score > or =F2 than non-Hispanic whites (P=0.002) and Hispanics (P=0.04). Ethnic differences in rates of NAFLD, NASH, and fibrosis > or =F2 persisted when controlling for demographic variables and features of the metabolic syndrome in logistic regression analysis. There were no significant differences in steatosis, NASH, or fibrosis > or =F2 between non-Hispanic whites and Hispanics.

CONCLUSIONS

African-American obesity surgery patients have a lower rate of NAFLD, NASH, and less severe fibrosis than non-Hispanic whites and Hispanics.

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Authors+Show Affiliations

Kallwitz ER
Department of Medicine, University of Illinois at Chicago, 840 S Wood Street, Chicago, IL 60612, USA. Kallwitz@uic.edu
Guzman G
No affiliation info available
TenCate V
No affiliation info available
Vitello J
No affiliation info available
Layden-Almer J
No affiliation info available
Berkes J
No affiliation info available
Patel R
No affiliation info available
Layden TJ
No affiliation info available
Cotler SJ
No affiliation info available

MeSH

AdultAfrican AmericansBariatric SurgeryBiopsy, NeedleEuropean Continental Ancestry GroupFatty LiverFemaleHispanic AmericansHumansLiverMaleObesity, MorbidRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19098851

Clinical Trial Links

BCAA Supplemental Study

Citation

Kallwitz, Eric R., et al. "The Histologic Spectrum of Liver Disease in African-American, non-Hispanic White, and Hispanic Obesity Surgery Patients." The American Journal of Gastroenterology, vol. 104, no. 1, 2009, pp. 64-9.
Kallwitz ER, Guzman G, TenCate V, et al. The histologic spectrum of liver disease in African-American, non-Hispanic white, and Hispanic obesity surgery patients. Am J Gastroenterol. 2009;104(1):64-9.
Kallwitz, E. R., Guzman, G., TenCate, V., Vitello, J., Layden-Almer, J., Berkes, J., Patel, R., Layden, T. J., & Cotler, S. J. (2009). The histologic spectrum of liver disease in African-American, non-Hispanic white, and Hispanic obesity surgery patients. The American Journal of Gastroenterology, 104(1), 64-9. https://doi.org/10.1038/ajg.2008.12
Kallwitz ER, et al. The Histologic Spectrum of Liver Disease in African-American, non-Hispanic White, and Hispanic Obesity Surgery Patients. Am J Gastroenterol. 2009;104(1):64-9. PubMed PMID: 19098851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The histologic spectrum of liver disease in African-American, non-Hispanic white, and Hispanic obesity surgery patients. AU - Kallwitz,Eric R, AU - Guzman,Grace, AU - TenCate,Veronica, AU - Vitello,Joseph, AU - Layden-Almer,Jennifer, AU - Berkes,Jamie, AU - Patel,Roshan, AU - Layden,Thomas J, AU - Cotler,Scott J, PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/2/25/medline SP - 64 EP - 9 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 104 IS - 1 N2 - OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a prominent cause of chronic liver disease in African Americans, non-Hispanic whites, and Hispanics. The aim of this study was to evaluate ethnic differences in the prevalence of NAFLD and non-alcoholic steatohepatitis (NASH) and to compare the severity of histologic features of NASH in obesity surgery patients. METHODS: Subjects consisted of 238 patients who had a routine liver biopsy at the time of obesity surgery. Demographic and clinical variables pertaining to the metabolic syndrome were collected retrospectively. Liver biopsies were evaluated according to the scoring system proposed by the Nonalcoholic Steatohepatitis Clinical Research Network and NASH was defined as a NASH activity score > or =5. RESULTS: African Americans had lower rates of steatosis than non-Hispanic whites (P<0.001) and Hispanics (P=0.03). Among patients with steatosis, African Americans had lower rates of NASH than non-Hispanic whites (P=0.05) and Hispanics (P=0.02) and lower rates of fibrosis score > or =F2 than non-Hispanic whites (P=0.002) and Hispanics (P=0.04). Ethnic differences in rates of NAFLD, NASH, and fibrosis > or =F2 persisted when controlling for demographic variables and features of the metabolic syndrome in logistic regression analysis. There were no significant differences in steatosis, NASH, or fibrosis > or =F2 between non-Hispanic whites and Hispanics. CONCLUSIONS: African-American obesity surgery patients have a lower rate of NAFLD, NASH, and less severe fibrosis than non-Hispanic whites and Hispanics. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/19098851/The_histologic_spectrum_of_liver_disease_in_African_American_non_Hispanic_white_and_Hispanic_obesity_surgery_patients_ L2 - https://Insights.ovid.com/pubmed?pmid=19098851 DB - PRIME DP - Unbound Medicine ER -