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Known risk factors do not explain disparities in gallstone prevalence between Denmark and northeast Germany.
Am J Gastroenterol 2009; 104(1):89-95AJ

Abstract

OBJECTIVES

Gallstones are a common disease worldwide, with disparities in the prevalence of the disease in different settings. The aim of the present study was to assess if different distributions of risk factors could explain the disparities in the prevalence of gallstone disease between Denmark and northeast Germany.

METHODS

Data of 5,559 subjects from the Danish MONICA survey and of 3,647 subjects of the German Study of Health in Pomerania were investigated. Gallstone disease was defined as a prior history of cholecystectomy or the presence of sonographically diagnosed gallstones. Logistic regression models were performed to assess the confounding effect of selected risk factors on regional disparities in gallstone disease.

RESULTS

After adjustment for age and vocational training, German subjects (women: Odds ratio, OR, 2.46 (95% confidence interval, CI: 2.07-2.91); men: OR, 1.89 (95% CI: 1.52-2.36)) had approximatively twice the odds of gallstones than Danes. Inclusion of lifestyle factors (smoking, alcohol intake, coffee use) did not affect this result, whereas adjustment for body mass index (BMI), lipids, diabetes, and use of oral contraceptives, menopausal hormone therapy (MHT) and parity (women only) changed the estimates considerable, but still Germans (women: OR, 1.65 (95% CI: 1.36-2.00); men: OR, 1.61 (95% CI: 1.27-2.04)) had higher odds than Danes.

CONCLUSIONS

German individuals had a higher prevalence of gallstones than Danes. This difference was partly explained by a higher BMI, unfavorable lipid levels, higher prevalence of diabetes, and a more frequent use of OR and MHT in German subjects. Further research is needed to evaluate the impact of unmeasured predictors, including genetic components, on the population-related risk of gallstones.

Authors+Show Affiliations

Institute for Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Strasse 48, Greifswald, Germany. nele.friedrich@uni-greifswald.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19098855

Citation

Friedrich, Nele, et al. "Known Risk Factors Do Not Explain Disparities in Gallstone Prevalence Between Denmark and Northeast Germany." The American Journal of Gastroenterology, vol. 104, no. 1, 2009, pp. 89-95.
Friedrich N, Völzke H, Hampe J, et al. Known risk factors do not explain disparities in gallstone prevalence between Denmark and northeast Germany. Am J Gastroenterol. 2009;104(1):89-95.
Friedrich, N., Völzke, H., Hampe, J., Lerch, M. M., & Jørgensen, T. (2009). Known risk factors do not explain disparities in gallstone prevalence between Denmark and northeast Germany. The American Journal of Gastroenterology, 104(1), pp. 89-95. doi:10.1038/ajg.2008.13.
Friedrich N, et al. Known Risk Factors Do Not Explain Disparities in Gallstone Prevalence Between Denmark and Northeast Germany. Am J Gastroenterol. 2009;104(1):89-95. PubMed PMID: 19098855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Known risk factors do not explain disparities in gallstone prevalence between Denmark and northeast Germany. AU - Friedrich,Nele, AU - Völzke,Henry, AU - Hampe,Jochen, AU - Lerch,Markus M, AU - Jørgensen,Torben, PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/2/25/medline SP - 89 EP - 95 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 104 IS - 1 N2 - OBJECTIVES: Gallstones are a common disease worldwide, with disparities in the prevalence of the disease in different settings. The aim of the present study was to assess if different distributions of risk factors could explain the disparities in the prevalence of gallstone disease between Denmark and northeast Germany. METHODS: Data of 5,559 subjects from the Danish MONICA survey and of 3,647 subjects of the German Study of Health in Pomerania were investigated. Gallstone disease was defined as a prior history of cholecystectomy or the presence of sonographically diagnosed gallstones. Logistic regression models were performed to assess the confounding effect of selected risk factors on regional disparities in gallstone disease. RESULTS: After adjustment for age and vocational training, German subjects (women: Odds ratio, OR, 2.46 (95% confidence interval, CI: 2.07-2.91); men: OR, 1.89 (95% CI: 1.52-2.36)) had approximatively twice the odds of gallstones than Danes. Inclusion of lifestyle factors (smoking, alcohol intake, coffee use) did not affect this result, whereas adjustment for body mass index (BMI), lipids, diabetes, and use of oral contraceptives, menopausal hormone therapy (MHT) and parity (women only) changed the estimates considerable, but still Germans (women: OR, 1.65 (95% CI: 1.36-2.00); men: OR, 1.61 (95% CI: 1.27-2.04)) had higher odds than Danes. CONCLUSIONS: German individuals had a higher prevalence of gallstones than Danes. This difference was partly explained by a higher BMI, unfavorable lipid levels, higher prevalence of diabetes, and a more frequent use of OR and MHT in German subjects. Further research is needed to evaluate the impact of unmeasured predictors, including genetic components, on the population-related risk of gallstones. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/19098855/Known_risk_factors_do_not_explain_disparities_in_gallstone_prevalence_between_Denmark_and_northeast_Germany_ L2 - http://Insights.ovid.com/pubmed?pmid=19098855 DB - PRIME DP - Unbound Medicine ER -