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Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma.
Arch Pharm Res. 2008 Dec; 31(12):1590-6.AP

Abstract

Kefiran is a major component of kefir which is a microbial symbiont mixture that produces jelly-like grains. This study aimed to evaluate the therapeutic availability of kefiran on the ovalbumin-induced asthma mouse model in which airway inflammation and airway hyper-responsiveness were found in the lung. BALB/c mice sensitized and challenged to ovalbumin were treated intra-gastrically with kefiran 1 hour before the ovalbumin challenge. Kefiran significantly suppressed ovalbumin-induced airway hyper-responsiveness (AHR) to inhaled methacholine. Administration of kefiran significantly inhibited the release of both eosinophils and other inflammatory cells into bronchoalveolar lavage (BAL) fluid and lung tissue which was measured by Diff-Quik. Interleukin-4 (IL-4) and interleukin-5 (IL-5) were also reduced to normal levels after administration of kefiran in BAL fluid. Histological studies demonstrate that kefiran substantially inhibited ovalbumin-induced eosinophilia in lung tissue by H&E staining and goblet cell hyperplasia in the airway by PAS staining. Taken above data, kefiran may be useful for the treatment of inflammation of lung tissue and airway hyper-responsiveness in a murine model and may have therapeutic potential for the treatment of allergic bronchial asthma.

Authors+Show Affiliations

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-806, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19099229

Citation

Kwon, Ok-Kyoung, et al. "Inhibitory Effect of Kefiran On Ovalbumin-induced Lung Inflammation in a Murine Model of Asthma." Archives of Pharmacal Research, vol. 31, no. 12, 2008, pp. 1590-6.
Kwon OK, Ahn KS, Lee MY, et al. Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma. Arch Pharm Res. 2008;31(12):1590-6.
Kwon, O. K., Ahn, K. S., Lee, M. Y., Kim, S. Y., Park, B. Y., Kim, M. K., Lee, I. Y., Oh, S. R., & Lee, H. K. (2008). Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma. Archives of Pharmacal Research, 31(12), 1590-6. https://doi.org/10.1007/s12272-001-2156-4
Kwon OK, et al. Inhibitory Effect of Kefiran On Ovalbumin-induced Lung Inflammation in a Murine Model of Asthma. Arch Pharm Res. 2008;31(12):1590-6. PubMed PMID: 19099229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma. AU - Kwon,Ok-Kyoung, AU - Ahn,Kyung-Seop, AU - Lee,Mee-Young, AU - Kim,So-Young, AU - Park,Bo-Young, AU - Kim,Mi-Kyoung, AU - Lee,In-Young, AU - Oh,Sei-Ryang, AU - Lee,Hyeong-Kyu, Y1 - 2008/12/20/ PY - 2008/09/01/received PY - 2008/11/13/accepted PY - 2008/11/12/revised PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/2/4/medline SP - 1590 EP - 6 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 31 IS - 12 N2 - Kefiran is a major component of kefir which is a microbial symbiont mixture that produces jelly-like grains. This study aimed to evaluate the therapeutic availability of kefiran on the ovalbumin-induced asthma mouse model in which airway inflammation and airway hyper-responsiveness were found in the lung. BALB/c mice sensitized and challenged to ovalbumin were treated intra-gastrically with kefiran 1 hour before the ovalbumin challenge. Kefiran significantly suppressed ovalbumin-induced airway hyper-responsiveness (AHR) to inhaled methacholine. Administration of kefiran significantly inhibited the release of both eosinophils and other inflammatory cells into bronchoalveolar lavage (BAL) fluid and lung tissue which was measured by Diff-Quik. Interleukin-4 (IL-4) and interleukin-5 (IL-5) were also reduced to normal levels after administration of kefiran in BAL fluid. Histological studies demonstrate that kefiran substantially inhibited ovalbumin-induced eosinophilia in lung tissue by H&E staining and goblet cell hyperplasia in the airway by PAS staining. Taken above data, kefiran may be useful for the treatment of inflammation of lung tissue and airway hyper-responsiveness in a murine model and may have therapeutic potential for the treatment of allergic bronchial asthma. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/19099229/Inhibitory_effect_of_kefiran_on_ovalbumin_induced_lung_inflammation_in_a_murine_model_of_asthma_ L2 - https://dx.doi.org/10.1007/s12272-001-2156-4 DB - PRIME DP - Unbound Medicine ER -