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Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E.
Int J Cosmet Sci. 2008 Dec; 30(6):453-8.IJ

Abstract

The stability of ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate in topical formulations was investigated by direct reverse phase high performance liquid chromatography after sample dilution with a suitable buffer - organic solvent mixture. Ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate are derivatives of ascorbic acid which differ in hydrolipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. According to the results, ascorbyl esters showed significant differences: sodium ascorbyl phosphate and magnesium ascorbyl phosphate are more stable derivatives of vitamin C than ascorbyl palmitate and may be easily used in cosmetic products.

Authors+Show Affiliations

Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina. asegall@ffyb.uba.arNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19099546

Citation

Segall, A I., and M A. Moyano. "Stability of Vitamin C Derivatives in Topical Formulations Containing Lipoic Acid, Vitamins a and E." International Journal of Cosmetic Science, vol. 30, no. 6, 2008, pp. 453-8.
Segall AI, Moyano MA. Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. Int J Cosmet Sci. 2008;30(6):453-8.
Segall, A. I., & Moyano, M. A. (2008). Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. International Journal of Cosmetic Science, 30(6), 453-8. https://doi.org/10.1111/j.1468-2494.2008.00473.x
Segall AI, Moyano MA. Stability of Vitamin C Derivatives in Topical Formulations Containing Lipoic Acid, Vitamins a and E. Int J Cosmet Sci. 2008;30(6):453-8. PubMed PMID: 19099546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. AU - Segall,A I, AU - Moyano,M A, PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/2/13/medline SP - 453 EP - 8 JF - International journal of cosmetic science JO - Int J Cosmet Sci VL - 30 IS - 6 N2 - The stability of ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate in topical formulations was investigated by direct reverse phase high performance liquid chromatography after sample dilution with a suitable buffer - organic solvent mixture. Ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate are derivatives of ascorbic acid which differ in hydrolipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. According to the results, ascorbyl esters showed significant differences: sodium ascorbyl phosphate and magnesium ascorbyl phosphate are more stable derivatives of vitamin C than ascorbyl palmitate and may be easily used in cosmetic products. SN - 1468-2494 UR - https://www.unboundmedicine.com/medline/citation/19099546/Stability_of_vitamin_C_derivatives_in_topical_formulations_containing_lipoic_acid_vitamins_A_and_E_ L2 - https://doi.org/10.1111/j.1468-2494.2008.00473.x DB - PRIME DP - Unbound Medicine ER -