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[Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction].
Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Jan; 36(1):68-71.ZX

Abstract

OBJECTIVE

To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI).

METHODS

MI was induced in male Sprague-Dawley rats by ligating the left coronary artery. Rats randomly received saline, carvedilol (10 mg.kg(-1).d(-1)) or metoprolol (20 mg.kg(-1).d(-1)) beginning at 4 weeks post MI for 8 weeks per gavage. Sham-operated rats serve as control. Collagen perivascular circumferential collagen area (PCVA), peri-coronary circumferential collagen area (VLCA) and interstitial collagen volume fraction (ICVF) as well as myocardial hydroxyproline content were determined after hemodynamic measurements at the study end.

RESULTS

LVEDP were significantly lower and +/- dp/dt significantly higher in carvedilol and metoprolol treated MI rats than that in saline treated MI rats. Myocardial hydroxyproline, PCVA/VLCA ratio and ICVF were significantly reduced in metoprolol, more significantly reduced in carvedilol treated MI rats compared to saline treated MI rats (all P < 0.05).

CONCLUSION

Metoprolol and carvedilol could decrease the concentration of hydroxyproline and ICVF in MI rats.

Authors+Show Affiliations

Emergency Center, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

19099933

Citation

Sun, Tao, et al. "[Effects of Carvedilol and Metoprolol On Cardiac Fibrosis in Rats With Experimental Myocardial Infarction]." Zhonghua Xin Xue Guan Bing Za Zhi, vol. 36, no. 1, 2008, pp. 68-71.
Sun T, Shen LH, Chen H, et al. [Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36(1):68-71.
Sun, T., Shen, L. H., Chen, H., Li, H. W., Guo, C. Y., Li, Z. Z., & Tang, C. S. (2008). [Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. Zhonghua Xin Xue Guan Bing Za Zhi, 36(1), 68-71.
Sun T, et al. [Effects of Carvedilol and Metoprolol On Cardiac Fibrosis in Rats With Experimental Myocardial Infarction]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36(1):68-71. PubMed PMID: 19099933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. AU - Sun,Tao, AU - Shen,Lu-Hua, AU - Chen,Hui, AU - Li,Hong-Wei, AU - Guo,Chun-Yan, AU - Li,Zhi-Zhong, AU - Tang,Chao-Shu, PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/8/12/medline SP - 68 EP - 71 JF - Zhonghua xin xue guan bing za zhi JO - Zhonghua Xin Xue Guan Bing Za Zhi VL - 36 IS - 1 N2 - OBJECTIVE: To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI). METHODS: MI was induced in male Sprague-Dawley rats by ligating the left coronary artery. Rats randomly received saline, carvedilol (10 mg.kg(-1).d(-1)) or metoprolol (20 mg.kg(-1).d(-1)) beginning at 4 weeks post MI for 8 weeks per gavage. Sham-operated rats serve as control. Collagen perivascular circumferential collagen area (PCVA), peri-coronary circumferential collagen area (VLCA) and interstitial collagen volume fraction (ICVF) as well as myocardial hydroxyproline content were determined after hemodynamic measurements at the study end. RESULTS: LVEDP were significantly lower and +/- dp/dt significantly higher in carvedilol and metoprolol treated MI rats than that in saline treated MI rats. Myocardial hydroxyproline, PCVA/VLCA ratio and ICVF were significantly reduced in metoprolol, more significantly reduced in carvedilol treated MI rats compared to saline treated MI rats (all P < 0.05). CONCLUSION: Metoprolol and carvedilol could decrease the concentration of hydroxyproline and ICVF in MI rats. SN - 0253-3758 UR - https://www.unboundmedicine.com/medline/citation/19099933/[Effects_of_carvedilol_and_metoprolol_on_cardiac_fibrosis_in_rats_with_experimental_myocardial_infarction]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3758&amp;year=2008&amp;vol=36&amp;issue=1&amp;fpage=68 DB - PRIME DP - Unbound Medicine ER -