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Patient-controlled analgesia combined with either ondansetron or ondansetron plus prochlorperazine for control of pain and nausea and vomiting in patients undergoing abdominal surgery.
J Clin Anesth. 2008 Dec; 20(8):594-600.JC

Abstract

STUDY OBJECTIVE

To compare ondansetron with ondansetron plus prochlorperazine, added to a patient-controlled analgesia (PCA) solution for control of postoperative nausea and vomiting (PONV).

DESIGN

Prospective, randomized, double-blinded study.

SETTING

University hospital.

PATIENTS

150 ASA physical status I, II, and III patients undergoing abdominal surgery.

INTERVENTIONS

Patients were given a PCA morphine solution containing either 30 mg of ondansetron (Group O), 30 mg of ondansetron plus 20 mg of prochlorperazine (Group OP), or no antiemetic (Group C; control group).

MEASUREMENTS

Demographic data were recorded, along with anesthetic and surgical time, total fluid intake, frequency of Postanesthesia Care Unit (PACU) PONV, discharge time and length of stay, frequency of PONV while on the hospital floor, highest nausea scores, total PCA morphine use, and PCA utilization times.

MAIN RESULTS

Demographic and intraoperative variables were similar in all groups. In the first 24 hours after surgery, nausea was higher in Group C than Group OP. Emesis in Group C was twice that of either Group O or Group OP. No differences were noted between groups in PACU PONV. Patients receiving ondansetron plus prochlorperazine when on the hospital floor had a lower frequency of nausea, while patients receiving ondansetron alone had a lower frequency of vomiting than did the control group. The adjusted odds of vomiting doubled for every 12 hours for Group C patients when receiving PCA.

CONCLUSIONS

Combination antiemetics added to PCA reduced emetic symptoms after abdominal surgery.

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Authors+Show Affiliations

Jellish WS
Department of Anesthesiology, Loyola University Medical Center, Maywood, IL 60153, USA. wjellis@lumc.edu
Owen K
No affiliation info available
Fluder E
No affiliation info available
Sawicki K
No affiliation info available
Sinacore J
No affiliation info available

MeSH

AbdomenAdultAnalgesia, Patient-ControlledAnalgesics, OpioidAntiemeticsDouble-Blind MethodDrug Therapy, CombinationFemaleHospitals, UniversityHumansMaleMiddle AgedMorphineOndansetronPain, PostoperativePostoperative Nausea and VomitingProchlorperazineProspective StudiesTime Factors

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19100932

Citation

Jellish, W Scott, et al. "Patient-controlled Analgesia Combined With Either Ondansetron or Ondansetron Plus Prochlorperazine for Control of Pain and Nausea and Vomiting in Patients Undergoing Abdominal Surgery." Journal of Clinical Anesthesia, vol. 20, no. 8, 2008, pp. 594-600.
Jellish WS, Owen K, Fluder E, et al. Patient-controlled analgesia combined with either ondansetron or ondansetron plus prochlorperazine for control of pain and nausea and vomiting in patients undergoing abdominal surgery. J Clin Anesth. 2008;20(8):594-600.
Jellish, W. S., Owen, K., Fluder, E., Sawicki, K., & Sinacore, J. (2008). Patient-controlled analgesia combined with either ondansetron or ondansetron plus prochlorperazine for control of pain and nausea and vomiting in patients undergoing abdominal surgery. Journal of Clinical Anesthesia, 20(8), 594-600. https://doi.org/10.1016/j.jclinane.2008.06.008
Jellish WS, et al. Patient-controlled Analgesia Combined With Either Ondansetron or Ondansetron Plus Prochlorperazine for Control of Pain and Nausea and Vomiting in Patients Undergoing Abdominal Surgery. J Clin Anesth. 2008;20(8):594-600. PubMed PMID: 19100932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patient-controlled analgesia combined with either ondansetron or ondansetron plus prochlorperazine for control of pain and nausea and vomiting in patients undergoing abdominal surgery. AU - Jellish,W Scott, AU - Owen,Kevin, AU - Fluder,Elaine, AU - Sawicki,Kristina, AU - Sinacore,James, PY - 2007/03/20/received PY - 2008/06/02/revised PY - 2008/06/04/accepted PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/2/26/medline SP - 594 EP - 600 JF - Journal of clinical anesthesia JO - J Clin Anesth VL - 20 IS - 8 N2 - STUDY OBJECTIVE: To compare ondansetron with ondansetron plus prochlorperazine, added to a patient-controlled analgesia (PCA) solution for control of postoperative nausea and vomiting (PONV). DESIGN: Prospective, randomized, double-blinded study. SETTING: University hospital. PATIENTS: 150 ASA physical status I, II, and III patients undergoing abdominal surgery. INTERVENTIONS: Patients were given a PCA morphine solution containing either 30 mg of ondansetron (Group O), 30 mg of ondansetron plus 20 mg of prochlorperazine (Group OP), or no antiemetic (Group C; control group). MEASUREMENTS: Demographic data were recorded, along with anesthetic and surgical time, total fluid intake, frequency of Postanesthesia Care Unit (PACU) PONV, discharge time and length of stay, frequency of PONV while on the hospital floor, highest nausea scores, total PCA morphine use, and PCA utilization times. MAIN RESULTS: Demographic and intraoperative variables were similar in all groups. In the first 24 hours after surgery, nausea was higher in Group C than Group OP. Emesis in Group C was twice that of either Group O or Group OP. No differences were noted between groups in PACU PONV. Patients receiving ondansetron plus prochlorperazine when on the hospital floor had a lower frequency of nausea, while patients receiving ondansetron alone had a lower frequency of vomiting than did the control group. The adjusted odds of vomiting doubled for every 12 hours for Group C patients when receiving PCA. CONCLUSIONS: Combination antiemetics added to PCA reduced emetic symptoms after abdominal surgery. SN - 0952-8180 UR - https://www.unboundmedicine.com/medline/citation/19100932/Patient_controlled_analgesia_combined_with_either_ondansetron_or_ondansetron_plus_prochlorperazine_for_control_of_pain_and_nausea_and_vomiting_in_patients_undergoing_abdominal_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-8180(08)00288-2 DB - PRIME DP - Unbound Medicine ER -