Tags

Type your tag names separated by a space and hit enter

Postnatal development of axosomatic synapses in the rat nucleus tractus solitarius: dorsal and ventral subnuclei differences.
Neurosci Lett. 2009 Jan 30; 450(2):217-20.NL

Abstract

Inhibitory axosomatic synapses could effectively suppress the excitability of postsynaptic cells. It is important to examine the development of inhibitory axosomatic synapses to understand the maturation of information processing. The caudal nucleus tractus solitarius (cNTS), which regulates the autonomic system, consists of several subnuclei. In the present study, development of axosomatic synapses in the dorsal and ventral subnuclei was examined by electron microscopy. In dorsal subnuclei, the percentage of GAD-positive terminals on the somata, the percentage of small cell somata with synapses and axosomatic synapse density drastically decreased from postnatal day (P) 5 to P10. In ventral subnuclei, the percentage of GAD-positive terminals on the soma, the percentage of small or large cell somata with synapses and axosomatic synapse density were maintained or increased from P5 to P10. Thus, decrease of inhibitory axosomatic synapses in dorsal subnuclei might facilitate maturation of fine receptive areas for peripheral inputs, while increase of inhibitory axosomatic synapses in ventral subnuclei might facilitate the establishment of an effective regulation system for cNTS output.

Authors+Show Affiliations

Department of Anatomy, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi Minato-ku, Tokyo 105-8461, Japan. ytashiro@jikei.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19101609

Citation

Tashiro, Yasura, et al. "Postnatal Development of Axosomatic Synapses in the Rat Nucleus Tractus Solitarius: Dorsal and Ventral Subnuclei Differences." Neuroscience Letters, vol. 450, no. 2, 2009, pp. 217-20.
Tashiro Y, Okada T, Kawai Y. Postnatal development of axosomatic synapses in the rat nucleus tractus solitarius: dorsal and ventral subnuclei differences. Neurosci Lett. 2009;450(2):217-20.
Tashiro, Y., Okada, T., & Kawai, Y. (2009). Postnatal development of axosomatic synapses in the rat nucleus tractus solitarius: dorsal and ventral subnuclei differences. Neuroscience Letters, 450(2), 217-20. https://doi.org/10.1016/j.neulet.2008.12.012
Tashiro Y, Okada T, Kawai Y. Postnatal Development of Axosomatic Synapses in the Rat Nucleus Tractus Solitarius: Dorsal and Ventral Subnuclei Differences. Neurosci Lett. 2009 Jan 30;450(2):217-20. PubMed PMID: 19101609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postnatal development of axosomatic synapses in the rat nucleus tractus solitarius: dorsal and ventral subnuclei differences. AU - Tashiro,Yasura, AU - Okada,Tomoaki, AU - Kawai,Yoshinori, Y1 - 2008/12/16/ PY - 2008/10/17/received PY - 2008/11/27/revised PY - 2008/12/10/accepted PY - 2008/12/23/entrez PY - 2008/12/23/pubmed PY - 2009/3/25/medline SP - 217 EP - 20 JF - Neuroscience letters JO - Neurosci. Lett. VL - 450 IS - 2 N2 - Inhibitory axosomatic synapses could effectively suppress the excitability of postsynaptic cells. It is important to examine the development of inhibitory axosomatic synapses to understand the maturation of information processing. The caudal nucleus tractus solitarius (cNTS), which regulates the autonomic system, consists of several subnuclei. In the present study, development of axosomatic synapses in the dorsal and ventral subnuclei was examined by electron microscopy. In dorsal subnuclei, the percentage of GAD-positive terminals on the somata, the percentage of small cell somata with synapses and axosomatic synapse density drastically decreased from postnatal day (P) 5 to P10. In ventral subnuclei, the percentage of GAD-positive terminals on the soma, the percentage of small or large cell somata with synapses and axosomatic synapse density were maintained or increased from P5 to P10. Thus, decrease of inhibitory axosomatic synapses in dorsal subnuclei might facilitate maturation of fine receptive areas for peripheral inputs, while increase of inhibitory axosomatic synapses in ventral subnuclei might facilitate the establishment of an effective regulation system for cNTS output. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/19101609/Postnatal_development_of_axosomatic_synapses_in_the_rat_nucleus_tractus_solitarius:_dorsal_and_ventral_subnuclei_differences_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)01709-6 DB - PRIME DP - Unbound Medicine ER -