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The frequency of autoimmune thyroid disorders in juvenile idiopathic arthritis.
Turk J Pediatr 2008 Sep-Oct; 50(5):462-5TJ

Abstract

Few studies have been performed to investigate autoimmune diseases associated with organ non-specific rheumatological disorders in children, such as juvenile idiopathic arthritis (IA). The objective in this study was to determine the frequency of autoimmune diseases of the thyroid gland in children with JIA. Eighty patients with JIA and 81 healthy sex- and age-matched controls were enrolled in the study. Serum free T3, free T4, thyroid stimulating hormone (TSH), anti-thyroglobulin antibodies, and anti-peroxidase antibodies were evaluated. The mean age was 11.5 +/- 5.5 years in the patient group and 10.5 +/- 4.9 years in the control group. Twenty-seven of the cases were classified as oligoarticular, 26 as polyarticular, 17 as enthesitis-related, 6 as systemic, and 4 as psoriatic arthritis. Autoimmune thyroid disease was found in 4 patients in the JIA group (5%). There were no significant differences between the study and control groups regarding the existence of anti-thyroid antibodies (p = 0.17). Girls were more likely to develop autoimmune thyroiditis (3 girls, 1 boy). Autoimmune thyroiditis was more frequent in patients who had a family history of thyroid disease (p = 0.02). There was no statistical correlation between rheumatoid factor (RF) and antinuclear antibody (ANA) positivity and autoimmune thyroiditis (p > 0.05). We conclude that there is no need for routine screening of serum thyroid function tests and thyroid antibody levels in patients with JIA in the absence of clinical symptoms.

Authors+Show Affiliations

Department of Pediatrics, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

19102051

Citation

Unsal, Erbil, et al. "The Frequency of Autoimmune Thyroid Disorders in Juvenile Idiopathic Arthritis." The Turkish Journal of Pediatrics, vol. 50, no. 5, 2008, pp. 462-5.
Unsal E, Oren O, Salar K, et al. The frequency of autoimmune thyroid disorders in juvenile idiopathic arthritis. Turk J Pediatr. 2008;50(5):462-5.
Unsal, E., Oren, O., Salar, K., Makay, B., Abaci, A., Ozhan, B., & Böber, E. (2008). The frequency of autoimmune thyroid disorders in juvenile idiopathic arthritis. The Turkish Journal of Pediatrics, 50(5), pp. 462-5.
Unsal E, et al. The Frequency of Autoimmune Thyroid Disorders in Juvenile Idiopathic Arthritis. Turk J Pediatr. 2008;50(5):462-5. PubMed PMID: 19102051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The frequency of autoimmune thyroid disorders in juvenile idiopathic arthritis. AU - Unsal,Erbil, AU - Oren,Oğuz, AU - Salar,Koray, AU - Makay,Balahan, AU - Abaci,Ayhan, AU - Ozhan,Bayram, AU - Böber,Ece, PY - 2008/12/24/entrez PY - 2008/12/24/pubmed PY - 2009/1/10/medline SP - 462 EP - 5 JF - The Turkish journal of pediatrics JO - Turk. J. Pediatr. VL - 50 IS - 5 N2 - Few studies have been performed to investigate autoimmune diseases associated with organ non-specific rheumatological disorders in children, such as juvenile idiopathic arthritis (IA). The objective in this study was to determine the frequency of autoimmune diseases of the thyroid gland in children with JIA. Eighty patients with JIA and 81 healthy sex- and age-matched controls were enrolled in the study. Serum free T3, free T4, thyroid stimulating hormone (TSH), anti-thyroglobulin antibodies, and anti-peroxidase antibodies were evaluated. The mean age was 11.5 +/- 5.5 years in the patient group and 10.5 +/- 4.9 years in the control group. Twenty-seven of the cases were classified as oligoarticular, 26 as polyarticular, 17 as enthesitis-related, 6 as systemic, and 4 as psoriatic arthritis. Autoimmune thyroid disease was found in 4 patients in the JIA group (5%). There were no significant differences between the study and control groups regarding the existence of anti-thyroid antibodies (p = 0.17). Girls were more likely to develop autoimmune thyroiditis (3 girls, 1 boy). Autoimmune thyroiditis was more frequent in patients who had a family history of thyroid disease (p = 0.02). There was no statistical correlation between rheumatoid factor (RF) and antinuclear antibody (ANA) positivity and autoimmune thyroiditis (p > 0.05). We conclude that there is no need for routine screening of serum thyroid function tests and thyroid antibody levels in patients with JIA in the absence of clinical symptoms. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/19102051/The_frequency_of_autoimmune_thyroid_disorders_in_juvenile_idiopathic_arthritis_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -