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[Experimental evidence of against cough activity of total alkaloids from Guiera senegalensis Lam. in guinea pig;].
Dakar Med. 2007; 52(2):130-4.DM

Abstract

INTRODUCTION

Against cough activity from Guiera senegalensis' leaves has been previously scientifically studied. However, to the best of our knowledge, active principles responsible of this activity were not yet identified. Thus, we undertook this work with the aim to evaluate the effect of total alkaloids from plant's leaves in cough induced in guinea pig by ammoniac inhalation.

MATERIAL AND METHODS

Guinea pigs were divided up in 5 groups of 10 and were crammed with distilled water (control), total alkaloids with 10, 25 and 30 mg/kg and codeine with 50 mg/kg. They were then exposed to ammoniac inhalations and the number of coughs was counted every hour, after cramming, during 5 min.

RESULTS

Our results show, after 5 hours, with the doses of 15, 25 and 30 mg/kg per os, that total alkaloids induce against cough activity, 2 hours after cramming (p < 0.01) and the difference was still significant 3, 4 and 5 hours after (p < 0.001). These alkaloids effects were comparable with codeine activity which was used as reference product.

CONCLUSION

Total alkaloids of Guiera senegalensis present an against cough activity and would be responsible of against cough activity of the plant.

Authors+Show Affiliations

Diatta W
Laboratoire de Pharmacognosie et Botanique, Faculté de Médecine, de Pharmacie et d'Odonto- Stomatologie, Université Cheikh Anta Diop, BP 5005, Dakar, Sénégal.
Fall AD
No affiliation info available
Dièye AM
No affiliation info available
Faty S
No affiliation info available
Bassène E
No affiliation info available
Faye B
No affiliation info available

MeSH

AlkaloidsAnimalsAntitussive AgentsButanonesCodeineCombretaceaeCoughDisease Models, AnimalDrug Therapy, CombinationFemaleGuinea PigsMaleNaphthalenesPhytotherapyPlant ExtractsPlant LeavesPlant PreparationsTime Factors

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

fre

PubMed ID

19102107

Citation

Diatta, W, et al. "[Experimental Evidence of Against Cough Activity of Total Alkaloids From Guiera Senegalensis Lam. in Guinea Pig;]." Dakar Medical, vol. 52, no. 2, 2007, pp. 130-4.
Diatta W, Fall AD, Dièye AM, et al. [Experimental evidence of against cough activity of total alkaloids from Guiera senegalensis Lam. in guinea pig;]. Dakar Med. 2007;52(2):130-4.
Diatta, W., Fall, A. D., Dièye, A. M., Faty, S., Bassène, E., & Faye, B. (2007). [Experimental evidence of against cough activity of total alkaloids from Guiera senegalensis Lam. in guinea pig;]. Dakar Medical, 52(2), 130-4.
Diatta W, et al. [Experimental Evidence of Against Cough Activity of Total Alkaloids From Guiera Senegalensis Lam. in Guinea Pig;]. Dakar Med. 2007;52(2):130-4. PubMed PMID: 19102107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Experimental evidence of against cough activity of total alkaloids from Guiera senegalensis Lam. in guinea pig;]. AU - Diatta,W, AU - Fall,A D, AU - Dièye,A M, AU - Faty,S, AU - Bassène,E, AU - Faye,B, PY - 2008/12/24/entrez PY - 2007/1/1/pubmed PY - 2009/1/10/medline SP - 130 EP - 4 JF - Dakar medical JO - Dakar Med VL - 52 IS - 2 N2 - INTRODUCTION: Against cough activity from Guiera senegalensis' leaves has been previously scientifically studied. However, to the best of our knowledge, active principles responsible of this activity were not yet identified. Thus, we undertook this work with the aim to evaluate the effect of total alkaloids from plant's leaves in cough induced in guinea pig by ammoniac inhalation. MATERIAL AND METHODS: Guinea pigs were divided up in 5 groups of 10 and were crammed with distilled water (control), total alkaloids with 10, 25 and 30 mg/kg and codeine with 50 mg/kg. They were then exposed to ammoniac inhalations and the number of coughs was counted every hour, after cramming, during 5 min. RESULTS: Our results show, after 5 hours, with the doses of 15, 25 and 30 mg/kg per os, that total alkaloids induce against cough activity, 2 hours after cramming (p < 0.01) and the difference was still significant 3, 4 and 5 hours after (p < 0.001). These alkaloids effects were comparable with codeine activity which was used as reference product. CONCLUSION: Total alkaloids of Guiera senegalensis present an against cough activity and would be responsible of against cough activity of the plant. SN - 0049-1101 UR - https://www.unboundmedicine.com/medline/citation/19102107/[Experimental_evidence_of_against_cough_activity_of_total_alkaloids_from_Guiera_senegalensis_Lam__in_guinea_pig DB - PRIME DP - Unbound Medicine ER -