Tags

Type your tag names separated by a space and hit enter

Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion.
Neurosci Lett. 2009 Feb 13; 451(1):34-9.NL

Abstract

Avulsion of ventral roots induces degeneration of most axotomized motoneurons. At present there are no effective strategies to prevent such neuronal loss and to preserve the affected spinal circuits. Interestingly, changes in the spinal cord network also occur during the course of the experimental model of multiple sclerosis (experimental autoimmune encephalomyelitis-EAE). Glatiramer acetate (GA) significantly reduces the seriousness of the symptoms during the exacerbation of EAE. However, little is known about its effects on motoneurons. In the present study, we investigated whether GA has an influence on synapse plasticity and glial reaction after ventral root avulsion (VRA). Lewis rats were subjected to the avulsion of lumbar ventral roots and treated with GA. The animals were sacrificed after 14 days of treatment and the spinal cords processed for immunohistochemistry. A correlation between the synaptic changes and glial activation was obtained by performing immunolabeling against synaptophysin, GFAP and Iba-1. GA treatment preserved synaptophysin labeling, and significantly reduced the glial reaction in the area surrounding the axotomized motoneurons. After ventral root avulsion, GA treatment was also neuroprotective. The present results indicate that the immunomodulator GA has an influence on the stability of nerve terminals in the spinal cord, which may in turn contribute to future treatment strategies after proximal lesions to spinal motoneurons.

Authors+Show Affiliations

Dept. of Anatomy - Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19103252

Citation

Scorisa, Juliana Milani, et al. "Glatiramer Acetate Positively Influences Spinal Motoneuron Survival and Synaptic Plasticity After Ventral Root Avulsion." Neuroscience Letters, vol. 451, no. 1, 2009, pp. 34-9.
Scorisa JM, Zanon RG, Freria CM, et al. Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion. Neurosci Lett. 2009;451(1):34-9.
Scorisa, J. M., Zanon, R. G., Freria, C. M., & de Oliveira, A. L. (2009). Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion. Neuroscience Letters, 451(1), 34-9. https://doi.org/10.1016/j.neulet.2008.12.017
Scorisa JM, et al. Glatiramer Acetate Positively Influences Spinal Motoneuron Survival and Synaptic Plasticity After Ventral Root Avulsion. Neurosci Lett. 2009 Feb 13;451(1):34-9. PubMed PMID: 19103252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion. AU - Scorisa,Juliana Milani, AU - Zanon,Renata Graciele, AU - Freria,Camila Marques, AU - de Oliveira,Alexandre Leite Rodrigues, Y1 - 2008/12/16/ PY - 2008/09/08/received PY - 2008/11/27/revised PY - 2008/12/10/accepted PY - 2008/12/24/entrez PY - 2008/12/24/pubmed PY - 2009/4/14/medline SP - 34 EP - 9 JF - Neuroscience letters JO - Neurosci. Lett. VL - 451 IS - 1 N2 - Avulsion of ventral roots induces degeneration of most axotomized motoneurons. At present there are no effective strategies to prevent such neuronal loss and to preserve the affected spinal circuits. Interestingly, changes in the spinal cord network also occur during the course of the experimental model of multiple sclerosis (experimental autoimmune encephalomyelitis-EAE). Glatiramer acetate (GA) significantly reduces the seriousness of the symptoms during the exacerbation of EAE. However, little is known about its effects on motoneurons. In the present study, we investigated whether GA has an influence on synapse plasticity and glial reaction after ventral root avulsion (VRA). Lewis rats were subjected to the avulsion of lumbar ventral roots and treated with GA. The animals were sacrificed after 14 days of treatment and the spinal cords processed for immunohistochemistry. A correlation between the synaptic changes and glial activation was obtained by performing immunolabeling against synaptophysin, GFAP and Iba-1. GA treatment preserved synaptophysin labeling, and significantly reduced the glial reaction in the area surrounding the axotomized motoneurons. After ventral root avulsion, GA treatment was also neuroprotective. The present results indicate that the immunomodulator GA has an influence on the stability of nerve terminals in the spinal cord, which may in turn contribute to future treatment strategies after proximal lesions to spinal motoneurons. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/19103252/Glatiramer_acetate_positively_influences_spinal_motoneuron_survival_and_synaptic_plasticity_after_ventral_root_avulsion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)01703-5 DB - PRIME DP - Unbound Medicine ER -