Tags

Type your tag names separated by a space and hit enter

Antinociceptive activity of 1-nitro-2-phenylethane, the main component of Aniba canelilla essential oil.
Phytomedicine. 2009 Jun; 16(6-7):555-9.P

Abstract

Aniba canelilla (H.B.K.) Mez is a medicinal plant used in the Amazon folk therapeutic as antispasmodic, antidiarreic, carminative, tonic agent and a stimulant of the digestive and central nervous system. Our preliminary studies showed that the plant essential oil has analgesic activity in mice. Now, we are reporting the antinociceptive effect of the compound 1-nitro-2-phenylethane (97.5%), the main component of the essential oil of Aniba canelilla, which was obtained by column chromatographic purification. In the writhing test this compound was dosed at 15, 25 and 50 mg/kg reducing the abdominal writhes in a significant manner; in the hot plate test it was assayed at 50, 100 and 200 mg/kg producing no alterations in the latency time when compared to the control; and in the formalin test the 1-nitro-2-phenylethane was tested at 50 and 25 mg/kg decreasing significantly the second phase of the algic stimulus. The study suggests that the 1-nitro-2-phenylethane has analgesic activity, probably of peripheral origin. The mechanism involved is not completely understood, however, the results suggest that the opioid receptors are involved in the antinociceptive action observed to 1-nitro-phenylethane.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

de Lima AB
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.
Santana MB
No affiliation info available
Cardoso AS
No affiliation info available
da Silva JK
No affiliation info available
Maia JG
No affiliation info available
Carvalho JC
No affiliation info available
Sousa PJ
No affiliation info available

MeSH

AnalgesicsAnimalsBenzene DerivativesLauraceaeMaleMiceOils, Volatile

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19103477

Citation

de Lima, Anderson B., et al. "Antinociceptive Activity of 1-nitro-2-phenylethane, the Main Component of Aniba Canelilla Essential Oil." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 16, no. 6-7, 2009, pp. 555-9.
de Lima AB, Santana MB, Cardoso AS, et al. Antinociceptive activity of 1-nitro-2-phenylethane, the main component of Aniba canelilla essential oil. Phytomedicine. 2009;16(6-7):555-9.
de Lima, A. B., Santana, M. B., Cardoso, A. S., da Silva, J. K., Maia, J. G., Carvalho, J. C., & Sousa, P. J. (2009). Antinociceptive activity of 1-nitro-2-phenylethane, the main component of Aniba canelilla essential oil. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 16(6-7), 555-9. https://doi.org/10.1016/j.phymed.2008.10.007
de Lima AB, et al. Antinociceptive Activity of 1-nitro-2-phenylethane, the Main Component of Aniba Canelilla Essential Oil. Phytomedicine. 2009;16(6-7):555-9. PubMed PMID: 19103477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive activity of 1-nitro-2-phenylethane, the main component of Aniba canelilla essential oil. AU - de Lima,Anderson B, AU - Santana,Maxwell B, AU - Cardoso,Alessandra S, AU - da Silva,Joyce Kelly R, AU - Maia,José Guilherme S, AU - Carvalho,José Carlos T, AU - Sousa,Pergentino José C, Y1 - 2008/12/21/ PY - 2008/10/08/received PY - 2008/10/23/accepted PY - 2008/12/24/entrez PY - 2008/12/24/pubmed PY - 2009/7/8/medline SP - 555 EP - 9 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 16 IS - 6-7 N2 - Aniba canelilla (H.B.K.) Mez is a medicinal plant used in the Amazon folk therapeutic as antispasmodic, antidiarreic, carminative, tonic agent and a stimulant of the digestive and central nervous system. Our preliminary studies showed that the plant essential oil has analgesic activity in mice. Now, we are reporting the antinociceptive effect of the compound 1-nitro-2-phenylethane (97.5%), the main component of the essential oil of Aniba canelilla, which was obtained by column chromatographic purification. In the writhing test this compound was dosed at 15, 25 and 50 mg/kg reducing the abdominal writhes in a significant manner; in the hot plate test it was assayed at 50, 100 and 200 mg/kg producing no alterations in the latency time when compared to the control; and in the formalin test the 1-nitro-2-phenylethane was tested at 50 and 25 mg/kg decreasing significantly the second phase of the algic stimulus. The study suggests that the 1-nitro-2-phenylethane has analgesic activity, probably of peripheral origin. The mechanism involved is not completely understood, however, the results suggest that the opioid receptors are involved in the antinociceptive action observed to 1-nitro-phenylethane. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/19103477/Antinociceptive_activity_of_1_nitro_2_phenylethane_the_main_component_of_Aniba_canelilla_essential_oil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(08)00194-3 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓9]

Related Citations

More