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Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery.
J Cardiothorac Vasc Anesth. 2009 Jun; 23(3):312-5.JC

Abstract

OBJECTIVE

This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery.

DESIGN

A prospective, randomized, double-blind, placebo-controlled study.

SETTING

The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University.

PARTICIPANTS

One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups.

INTERVENTIONS

Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline.

MEASUREMENT AND MAIN RESULTS

Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units).

CONCLUSION

Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products.

Authors+Show Affiliations

Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran. r-jalaeian@mums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19103500

Citation

Taghaddomi, Reza Jalaeian, et al. "Tranexamic Acid Reduces Blood Loss in Off-pump Coronary Artery Bypass Surgery." Journal of Cardiothoracic and Vascular Anesthesia, vol. 23, no. 3, 2009, pp. 312-5.
Taghaddomi RJ, Mirzaee A, Attar AS, et al. Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2009;23(3):312-5.
Taghaddomi, R. J., Mirzaee, A., Attar, A. S., & Shirdel, A. (2009). Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery. Journal of Cardiothoracic and Vascular Anesthesia, 23(3), 312-5. https://doi.org/10.1053/j.jvca.2008.09.018
Taghaddomi RJ, et al. Tranexamic Acid Reduces Blood Loss in Off-pump Coronary Artery Bypass Surgery. J Cardiothorac Vasc Anesth. 2009;23(3):312-5. PubMed PMID: 19103500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery. AU - Taghaddomi,Reza Jalaeian, AU - Mirzaee,Asadollah, AU - Attar,Alireza Sharifian, AU - Shirdel,Abbas, Y1 - 2008/12/21/ PY - 2008/05/04/received PY - 2008/12/24/entrez PY - 2008/12/24/pubmed PY - 2010/3/2/medline SP - 312 EP - 5 JF - Journal of cardiothoracic and vascular anesthesia JO - J Cardiothorac Vasc Anesth VL - 23 IS - 3 N2 - OBJECTIVE: This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery. DESIGN: A prospective, randomized, double-blind, placebo-controlled study. SETTING: The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University. PARTICIPANTS: One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups. INTERVENTIONS: Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline. MEASUREMENT AND MAIN RESULTS: Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units). CONCLUSION: Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products. SN - 1532-8422 UR - https://www.unboundmedicine.com/medline/citation/19103500/Tranexamic_acid_reduces_blood_loss_in_off_pump_coronary_artery_bypass_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-0770(08)00299-1 DB - PRIME DP - Unbound Medicine ER -