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Characterization of ternary complexes of meloxicam-HPbetaCD and PVP or L-arginine prepared by the spray-drying technique.
Acta Pharm. 2008 Dec; 58(4):455-66.AP

Abstract

Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-beta-cyclodextrin (HPbetaCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid such as L-arginine, were prepared by the spray-drying technique. The solubilizing efficiency, physical properties and dissolution behaviour of each ternary system of ME-HPbetaCD with either PVP or L-arginine were compared with those of the corresponding binary system of ME-HPbetaCD. Tablets compressed from the ternary system of ME-HPbetaCD-L-arginine were compared with plain and commercial tablets. Phase solubility experiments suggested the formation of an inclusion complex of AL type. Ternary system of ME-HPbetaCD-L-arginine exhibited a stability constant 30.3 times higher than the binary system of ME-HPbetaCD, while the ternary system of ME-HPbetaCD-PVP increased the stability constant 2.2 times only. The prepared complexes were characterized by scanning electron microscopy, differential scanning calorimetry and infra red spectroscopy. Ternary solid complexes indicated the presence of strong interactions between the components. The dissolution behaviour of ME from different ternary complexes was higher than its dissolution from the binary system. Tablets compressed from ternary complexes of ME-HPbetaCD-L-arginine highly improved drug release compared to plain and commercial tablets.

Authors+Show Affiliations

Department of Industrial Pharmacy, University of Alexandria, Alexandria, Egypt. hodaelmaradny@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19103579

Citation

El-Maradny, Hoda A., et al. "Characterization of Ternary Complexes of meloxicam-HPbetaCD and PVP or L-arginine Prepared By the Spray-drying Technique." Acta Pharmaceutica (Zagreb, Croatia), vol. 58, no. 4, 2008, pp. 455-66.
El-Maradny HA, Mortada SA, Kamel OA, et al. Characterization of ternary complexes of meloxicam-HPbetaCD and PVP or L-arginine prepared by the spray-drying technique. Acta Pharm. 2008;58(4):455-66.
El-Maradny, H. A., Mortada, S. A., Kamel, O. A., & Hikal, A. H. (2008). Characterization of ternary complexes of meloxicam-HPbetaCD and PVP or L-arginine prepared by the spray-drying technique. Acta Pharmaceutica (Zagreb, Croatia), 58(4), 455-66. https://doi.org/10.2478/v10007-008-0029-9
El-Maradny HA, et al. Characterization of Ternary Complexes of meloxicam-HPbetaCD and PVP or L-arginine Prepared By the Spray-drying Technique. Acta Pharm. 2008;58(4):455-66. PubMed PMID: 19103579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of ternary complexes of meloxicam-HPbetaCD and PVP or L-arginine prepared by the spray-drying technique. AU - El-Maradny,Hoda A, AU - Mortada,Sana A, AU - Kamel,Ola A, AU - Hikal,Ahmed H, PY - 2008/12/24/entrez PY - 2008/12/24/pubmed PY - 2009/1/28/medline SP - 455 EP - 66 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 58 IS - 4 N2 - Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-beta-cyclodextrin (HPbetaCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid such as L-arginine, were prepared by the spray-drying technique. The solubilizing efficiency, physical properties and dissolution behaviour of each ternary system of ME-HPbetaCD with either PVP or L-arginine were compared with those of the corresponding binary system of ME-HPbetaCD. Tablets compressed from the ternary system of ME-HPbetaCD-L-arginine were compared with plain and commercial tablets. Phase solubility experiments suggested the formation of an inclusion complex of AL type. Ternary system of ME-HPbetaCD-L-arginine exhibited a stability constant 30.3 times higher than the binary system of ME-HPbetaCD, while the ternary system of ME-HPbetaCD-PVP increased the stability constant 2.2 times only. The prepared complexes were characterized by scanning electron microscopy, differential scanning calorimetry and infra red spectroscopy. Ternary solid complexes indicated the presence of strong interactions between the components. The dissolution behaviour of ME from different ternary complexes was higher than its dissolution from the binary system. Tablets compressed from ternary complexes of ME-HPbetaCD-L-arginine highly improved drug release compared to plain and commercial tablets. SN - 1330-0075 UR - https://www.unboundmedicine.com/medline/citation/19103579/Characterization_of_ternary_complexes_of_meloxicam_HPbetaCD_and_PVP_or_L_arginine_prepared_by_the_spray_drying_technique_ L2 - https://content.sciendo.com/doi/10.2478/v10007-008-0029-9 DB - PRIME DP - Unbound Medicine ER -