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Determination of copper and iron in biological samples of viral hepatitis (A-E) female patients.
Biol Trace Elem Res. 2009 Summer; 129(1-3):78-87.BT

Abstract

There is accumulative evidence that the metabolism of iron and copper is altered in viral hepatic diseases, and these nutrients might have specific roles in their pathogenesis and progress. The aim of present study was to compare the level of copper (Cu) and iron (Fe) in biological samples (serum, urine, and scalp hair) of female patients suffering from different viral hepatitis (A, B, C, D, and E; n = 253) of age range 31-45 years. For comparative study, 95 healthy females of the same age group residing in the same city were selected. The elements in the biological samples were analyzed by flame atomic absorption spectrophotometry, prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked by using certified reference materials (CRMs) and with those values obtained by conventional wet acid digestion method on same CRMs. The results of this study showed that the mean values of Cu and Fe were higher in sera and scalp hair samples of hepatitis patients than age-matched control subjects, while the difference was significant (p < 0.001), in the cases of viral hepatitis B and viral hepatitis C as compared to viral hepatitis A, D, and E. The urinary levels of these elements were found higher in the hepatitis patients than in the age-matched healthy controls (p < 0.05). These results are consistent with literature-reported data, confirming that hepatic iron and copper overload can directly cause lipid peroxidation and eventually hepatic damage.

Authors+Show Affiliations

National Center of Excellence in Analytical Chemistry, Sindh University, Jamshoro, Pakistan. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19104758

Citation

Afridi, Hassan Imran, et al. "Determination of Copper and Iron in Biological Samples of Viral Hepatitis (A-E) Female Patients." Biological Trace Element Research, vol. 129, no. 1-3, 2009, pp. 78-87.
Afridi HI, Kazi TG, Kazi NG, et al. Determination of copper and iron in biological samples of viral hepatitis (A-E) female patients. Biol Trace Elem Res. 2009;129(1-3):78-87.
Afridi, H. I., Kazi, T. G., Kazi, N. G., Jamali, M. K., Sarfaraz, R. A., Arain, M. B., Kandhro, G. A., Shah, A. Q., Baig, J. A., Jalbani, N., & Ansari, R. (2009). Determination of copper and iron in biological samples of viral hepatitis (A-E) female patients. Biological Trace Element Research, 129(1-3), 78-87. https://doi.org/10.1007/s12011-008-8297-2
Afridi HI, et al. Determination of Copper and Iron in Biological Samples of Viral Hepatitis (A-E) Female Patients. Biol Trace Elem Res. 2009;129(1-3):78-87. PubMed PMID: 19104758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of copper and iron in biological samples of viral hepatitis (A-E) female patients. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Kazi,Naveed Gul, AU - Jamali,Mohammad Khan, AU - Sarfaraz,Raja Adil, AU - Arain,Mohammad Balal, AU - Kandhro,Ghulam Abbas, AU - Shah,Abdul Qadir, AU - Baig,Jamil Ahmed, AU - Jalbani,Nusrat, AU - Ansari,Rehana, Y1 - 2008/12/23/ PY - 2008/05/31/received PY - 2008/12/09/accepted PY - 2008/12/24/entrez PY - 2008/12/24/pubmed PY - 2009/7/17/medline SP - 78 EP - 87 JF - Biological trace element research JO - Biol Trace Elem Res VL - 129 IS - 1-3 N2 - There is accumulative evidence that the metabolism of iron and copper is altered in viral hepatic diseases, and these nutrients might have specific roles in their pathogenesis and progress. The aim of present study was to compare the level of copper (Cu) and iron (Fe) in biological samples (serum, urine, and scalp hair) of female patients suffering from different viral hepatitis (A, B, C, D, and E; n = 253) of age range 31-45 years. For comparative study, 95 healthy females of the same age group residing in the same city were selected. The elements in the biological samples were analyzed by flame atomic absorption spectrophotometry, prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked by using certified reference materials (CRMs) and with those values obtained by conventional wet acid digestion method on same CRMs. The results of this study showed that the mean values of Cu and Fe were higher in sera and scalp hair samples of hepatitis patients than age-matched control subjects, while the difference was significant (p < 0.001), in the cases of viral hepatitis B and viral hepatitis C as compared to viral hepatitis A, D, and E. The urinary levels of these elements were found higher in the hepatitis patients than in the age-matched healthy controls (p < 0.05). These results are consistent with literature-reported data, confirming that hepatic iron and copper overload can directly cause lipid peroxidation and eventually hepatic damage. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/19104758/Determination_of_copper_and_iron_in_biological_samples_of_viral_hepatitis__A_E__female_patients_ L2 - https://dx.doi.org/10.1007/s12011-008-8297-2 DB - PRIME DP - Unbound Medicine ER -