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Novel atherogenesis markers for identification of patients with a multivessel coronary artery disease.
Kardiol Pol. 2008 Nov; 66(11):1173-80; discussion 1181-2.KP

Abstract

BACKGROUND

Patients with advanced coronary artery disease (CAD) have an unfovourable prognosis. Therefore, early identification of this high-risk group is important.

AIM

To asses the utility of clinical, electrographic and echocardiographic parameters, supported by novel atherogenesis markers, to identify patients with triple vessel coronary artery disease (CAD).

METHODS

The study group comprised 37 patients (29 males, mean age 64+/-8 years) suffering from multivessel CAD and a control group of 16 patients (8 males, mean age 60+/-10 years), in whom - despite typical stenocardial symptoms, positive exercise stress test and segmental contractility disturbances - coronary angiography did not reveal any haemodynamically significant CAD. Apart from coronary angiography, each patient had additionally an entire test panel performed assessing both the disease severity and the presence of other systemic dysfunction. Mean Gensini score in the study group was 91.9+/-43.8, including proximal Gensini score 52.6+/-45.6 and distal one 39.4+/-29.7.

RESULTS

Patients with triple vessel disease had a long history of angina (mean 84 months), of whom 30 (81%) experienced at least Q-wave myocardial infarction (MI). ECG changes typical for ischaemia were observed more often than in the control group. Also in patients with triple vessel disease echocardiography showed more escalated segmental contractility disorders, and left ventricular ejection fraction in this group was significantly lower than in the control group (44 vs. 55%, p <0.001). There were significant differences between CAD patients and control groups with respect to serum levels of: adiponectin (10.5+/-4.2 vs. 17.6+/-3 microg/ml, p=0.001), resistin (13.7+/-6.1 vs. 7.2+/-2.4 ng/ml, p=0.007), TNF-alpha (4.2+/-2.9 vs. 2.1+/-1.1 pg/ml, p=0.02) and IL-8 (18.4+/-4.1 vs. 12.2+/-4.1 pg/ml, p=0.008). Significant differences were also noted in lipid profile (total cholesterol: 201+/-47.1 vs. 183+/-18 mg/dl, NS; HDL cholesterol: 45+/-8.5 vs. 54+/-11 mg/dl, p=0.005; LDL cholesterol: 126.1+/-46.9 vs. 102+/-29 mg/dl, p=0.004), NT-proBNP [516 (174-1426) vs. 187 (39-573) pg/ml, p=0.02] and fasting blood glucose levels (97+/-14 vs. 94+/-11 mg/dl, p=0.03). Significantly lower serum adiponectin levels were observed in men and tobacco smokers.

CONCLUSIONS

Medical history, supported by interpretation of selected, routine imaging studies and novel biochemical markers, such as adiponectin, resistin, TNF-alpha, IL-8 or NT-proBNP, seem to be the key factors when assessing the risk of presence of advanced coronary artery atherosclerosis.

Authors+Show Affiliations

2nd Chair and Department of Cardiology, Medical University, Lotz, Poland. rkrecki@gazeta.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19105094

Citation

Krecki, Radosław, et al. "Novel Atherogenesis Markers for Identification of Patients With a Multivessel Coronary Artery Disease." Kardiologia Polska, vol. 66, no. 11, 2008, pp. 1173-80; discussion 1181-2.
Krecki R, Drozdz J, Szcześniak P, et al. Novel atherogenesis markers for identification of patients with a multivessel coronary artery disease. Kardiol Pol. 2008;66(11):1173-80; discussion 1181-2.
Krecki, R., Drozdz, J., Szcześniak, P., Orszulak-Michalak, D., & Krzemińska-Pakuła, M. (2008). Novel atherogenesis markers for identification of patients with a multivessel coronary artery disease. Kardiologia Polska, 66(11), 1173-80; discussion 1181-2.
Krecki R, et al. Novel Atherogenesis Markers for Identification of Patients With a Multivessel Coronary Artery Disease. Kardiol Pol. 2008;66(11):1173-80; discussion 1181-2. PubMed PMID: 19105094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel atherogenesis markers for identification of patients with a multivessel coronary artery disease. AU - Krecki,Radosław, AU - Drozdz,Jarosław, AU - Szcześniak,Piotr, AU - Orszulak-Michalak,Daria, AU - Krzemińska-Pakuła,Maria, PY - 2008/12/24/entrez PY - 2008/12/24/pubmed PY - 2009/3/25/medline SP - 1173-80; discussion 1181-2 JF - Kardiologia polska JO - Kardiol Pol VL - 66 IS - 11 N2 - BACKGROUND: Patients with advanced coronary artery disease (CAD) have an unfovourable prognosis. Therefore, early identification of this high-risk group is important. AIM: To asses the utility of clinical, electrographic and echocardiographic parameters, supported by novel atherogenesis markers, to identify patients with triple vessel coronary artery disease (CAD). METHODS: The study group comprised 37 patients (29 males, mean age 64+/-8 years) suffering from multivessel CAD and a control group of 16 patients (8 males, mean age 60+/-10 years), in whom - despite typical stenocardial symptoms, positive exercise stress test and segmental contractility disturbances - coronary angiography did not reveal any haemodynamically significant CAD. Apart from coronary angiography, each patient had additionally an entire test panel performed assessing both the disease severity and the presence of other systemic dysfunction. Mean Gensini score in the study group was 91.9+/-43.8, including proximal Gensini score 52.6+/-45.6 and distal one 39.4+/-29.7. RESULTS: Patients with triple vessel disease had a long history of angina (mean 84 months), of whom 30 (81%) experienced at least Q-wave myocardial infarction (MI). ECG changes typical for ischaemia were observed more often than in the control group. Also in patients with triple vessel disease echocardiography showed more escalated segmental contractility disorders, and left ventricular ejection fraction in this group was significantly lower than in the control group (44 vs. 55%, p <0.001). There were significant differences between CAD patients and control groups with respect to serum levels of: adiponectin (10.5+/-4.2 vs. 17.6+/-3 microg/ml, p=0.001), resistin (13.7+/-6.1 vs. 7.2+/-2.4 ng/ml, p=0.007), TNF-alpha (4.2+/-2.9 vs. 2.1+/-1.1 pg/ml, p=0.02) and IL-8 (18.4+/-4.1 vs. 12.2+/-4.1 pg/ml, p=0.008). Significant differences were also noted in lipid profile (total cholesterol: 201+/-47.1 vs. 183+/-18 mg/dl, NS; HDL cholesterol: 45+/-8.5 vs. 54+/-11 mg/dl, p=0.005; LDL cholesterol: 126.1+/-46.9 vs. 102+/-29 mg/dl, p=0.004), NT-proBNP [516 (174-1426) vs. 187 (39-573) pg/ml, p=0.02] and fasting blood glucose levels (97+/-14 vs. 94+/-11 mg/dl, p=0.03). Significantly lower serum adiponectin levels were observed in men and tobacco smokers. CONCLUSIONS: Medical history, supported by interpretation of selected, routine imaging studies and novel biochemical markers, such as adiponectin, resistin, TNF-alpha, IL-8 or NT-proBNP, seem to be the key factors when assessing the risk of presence of advanced coronary artery atherosclerosis. SN - 0022-9032 UR - https://www.unboundmedicine.com/medline/citation/19105094/Novel_atherogenesis_markers_for_identification_of_patients_with_a_multivessel_coronary_artery_disease_ L2 - https://medlineplus.gov/coronaryarterydisease.html DB - PRIME DP - Unbound Medicine ER -