Tags

Type your tag names separated by a space and hit enter

Do carotid artery diameters manifest early evidence of atherosclerosis in women with rheumatoid arthritis?
J Womens Health (Larchmt) 2009 Jan-Feb; 18(1):21-9JW

Abstract

OBJECTIVE

Given the high incidence of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA), we examined the associations between RA diagnosis and characteristics and evidence of carotid atherosclerosis. We take a unique approach by evaluating lumen and interadventitial diameters in addition to intima-media thickness and plaque.

METHODS

Ninety-three women with RA were matched with 93 healthy women by age, race, and menopause status. In cross-sectional analyses, we compared common carotid artery measures between groups and examined their relationships with measures of RA severity and activity.

RESULTS

Mean age was 53.3 years, and median RA duration was 14 years. Lumen diameter in patients was significantly greater than in healthy women (5.50 vs. 5.19 mm, p < 0.001), as was interadventitial diameter (6.92 vs. 6.61 mm, p < 0.001). Having RA also was independently associated with greater lumen (beta = 0.256, p < 0.01) and interadventitial (beta = 0.261, p < 0.01) diameters, after controlling for cardiovascular risk factors and intima-media thickness. Carotid intima-media thickness (0.70 vs. 0.71 mm) was similar, and the prevalence of carotid plaque in patients (21%) was higher but not statistically different from healthy women (15%). In patients with RA, we found positive associations between methotrexate dose and interadventitial diameter, between hypothyroidism and intima-media thickness, and between hypothyroidism and soluble endothelial adhesion molecule and plaque, independent of cardiovascular risk factors.

CONCLUSIONS

Women with RA have increased carotid artery diameters compared with healthy women. This may reflect premature vascular aging and may be an early indicator of increased cardiovascular risk.

Authors+Show Affiliations

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. schottll@upmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19105681

Citation

Schott, Laura L., et al. "Do Carotid Artery Diameters Manifest Early Evidence of Atherosclerosis in Women With Rheumatoid Arthritis?" Journal of Women's Health (2002), vol. 18, no. 1, 2009, pp. 21-9.
Schott LL, Kao AH, Cunningham A, et al. Do carotid artery diameters manifest early evidence of atherosclerosis in women with rheumatoid arthritis? J Womens Health (Larchmt). 2009;18(1):21-9.
Schott, L. L., Kao, A. H., Cunningham, A., Wildman, R. P., Kuller, L. H., Sutton-Tyrrell, K., & Wasko, M. C. (2009). Do carotid artery diameters manifest early evidence of atherosclerosis in women with rheumatoid arthritis? Journal of Women's Health (2002), 18(1), pp. 21-9. doi:10.1089/jwh.2008.0797.
Schott LL, et al. Do Carotid Artery Diameters Manifest Early Evidence of Atherosclerosis in Women With Rheumatoid Arthritis. J Womens Health (Larchmt). 2009;18(1):21-9. PubMed PMID: 19105681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do carotid artery diameters manifest early evidence of atherosclerosis in women with rheumatoid arthritis? AU - Schott,Laura L, AU - Kao,Amy H, AU - Cunningham,Amy, AU - Wildman,Rachel P, AU - Kuller,Lewis H, AU - Sutton-Tyrrell,Kim, AU - Wasko,Mary Chester M, PY - 2008/12/25/entrez PY - 2008/12/25/pubmed PY - 2009/4/28/medline SP - 21 EP - 9 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 18 IS - 1 N2 - OBJECTIVE: Given the high incidence of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA), we examined the associations between RA diagnosis and characteristics and evidence of carotid atherosclerosis. We take a unique approach by evaluating lumen and interadventitial diameters in addition to intima-media thickness and plaque. METHODS: Ninety-three women with RA were matched with 93 healthy women by age, race, and menopause status. In cross-sectional analyses, we compared common carotid artery measures between groups and examined their relationships with measures of RA severity and activity. RESULTS: Mean age was 53.3 years, and median RA duration was 14 years. Lumen diameter in patients was significantly greater than in healthy women (5.50 vs. 5.19 mm, p < 0.001), as was interadventitial diameter (6.92 vs. 6.61 mm, p < 0.001). Having RA also was independently associated with greater lumen (beta = 0.256, p < 0.01) and interadventitial (beta = 0.261, p < 0.01) diameters, after controlling for cardiovascular risk factors and intima-media thickness. Carotid intima-media thickness (0.70 vs. 0.71 mm) was similar, and the prevalence of carotid plaque in patients (21%) was higher but not statistically different from healthy women (15%). In patients with RA, we found positive associations between methotrexate dose and interadventitial diameter, between hypothyroidism and intima-media thickness, and between hypothyroidism and soluble endothelial adhesion molecule and plaque, independent of cardiovascular risk factors. CONCLUSIONS: Women with RA have increased carotid artery diameters compared with healthy women. This may reflect premature vascular aging and may be an early indicator of increased cardiovascular risk. SN - 1931-843X UR - https://www.unboundmedicine.com/medline/citation/19105681/Do_carotid_artery_diameters_manifest_early_evidence_of_atherosclerosis_in_women_with_rheumatoid_arthritis L2 - https://www.liebertpub.com/doi/full/10.1089/jwh.2008.0797?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -