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Oxygen radical generation as an index of neurotoxic damage.
Biomed Environ Sci 1991; 4(1-2):217-23BE

Abstract

Biochemical, anatomical, and physiological characteristics of the brain make it especially vulnerable to insult. Specifically, some of these characteristics such as myelin and a high energy requirement provide for the introduction of free radical-induced insult. Recently, the biochemistry of free radicals has received considerable attention. It also has become increasingly suggestive that many drug and chemical-induced toxicities may be evoked via free radicals and oxidative stress. Major points addressed in this work are the regulation of neural-free radical generation by antioxidants and protective enzymes, xenobiotic-induced disruption of cerebral redox status, and specific examples of neurotoxic agent-induced alterations in free radicals as measured by the fluorescent probe dichlorofluorescein. This article considers that free radical mechanisms may contribute significantly to the properties of several diverse neurotoxic agents and proposes that free radicals may be common phenomena of neurotoxicity.

Authors+Show Affiliations

Department of Community and Environmental Medicine, University of California, Irvine 92717.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1910598

Citation

Bondy, S C., and C P. LeBell. "Oxygen Radical Generation as an Index of Neurotoxic Damage." Biomedical and Environmental Sciences : BES, vol. 4, no. 1-2, 1991, pp. 217-23.
Bondy SC, LeBell CP. Oxygen radical generation as an index of neurotoxic damage. Biomed Environ Sci. 1991;4(1-2):217-23.
Bondy, S. C., & LeBell, C. P. (1991). Oxygen radical generation as an index of neurotoxic damage. Biomedical and Environmental Sciences : BES, 4(1-2), pp. 217-23.
Bondy SC, LeBell CP. Oxygen Radical Generation as an Index of Neurotoxic Damage. Biomed Environ Sci. 1991;4(1-2):217-23. PubMed PMID: 1910598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxygen radical generation as an index of neurotoxic damage. AU - Bondy,S C, AU - LeBell,C P, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 217 EP - 23 JF - Biomedical and environmental sciences : BES JO - Biomed. Environ. Sci. VL - 4 IS - 1-2 N2 - Biochemical, anatomical, and physiological characteristics of the brain make it especially vulnerable to insult. Specifically, some of these characteristics such as myelin and a high energy requirement provide for the introduction of free radical-induced insult. Recently, the biochemistry of free radicals has received considerable attention. It also has become increasingly suggestive that many drug and chemical-induced toxicities may be evoked via free radicals and oxidative stress. Major points addressed in this work are the regulation of neural-free radical generation by antioxidants and protective enzymes, xenobiotic-induced disruption of cerebral redox status, and specific examples of neurotoxic agent-induced alterations in free radicals as measured by the fluorescent probe dichlorofluorescein. This article considers that free radical mechanisms may contribute significantly to the properties of several diverse neurotoxic agents and proposes that free radicals may be common phenomena of neurotoxicity. SN - 0895-3988 UR - https://www.unboundmedicine.com/medline/citation/1910598/Oxygen_radical_generation_as_an_index_of_neurotoxic_damage_ DB - PRIME DP - Unbound Medicine ER -