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Preparation and properties of cyclodextrin/PNIPAm microgels.

Abstract

A two-stage precipitation polymerization in aqueous solution was used to prepare beta-cyclodextrin/poly(N-isopropylacrylamide) (beta-CD/PNIPAm) core-shell microgels. At the first stage, core microgels with CD moieties were synthesized by precipitation copolymerization of N-isopropylacrylamide (NIPAm) with a monovinyl beta-CD monomer. At the second stage, using the core particles as seeds, PNIPAm shell were further added onto the seeds by NIPAm polymerization. The microgels were characterized by means of Zetasizer Nano-ZS dynamic light scattering, TEM, IR, NMR, DSC, and TGA measurements. Using paeonol as a model drug molecule, the release behaviors of the microgels were investigated. The result indicates that the core-shell microgels could respond to change in temperature. Furthermore, the release of paeonol was related to supramolecular inclusion behavior of beta-CD and temperature sensitivity of PNIPAm.

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  • Authors+Show Affiliations

    ,

    Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an, PR China. yyliu666@yahoo.com.cn

    , , ,

    Source

    Macromolecular bioscience 9:5 2009 May 13 pg 525-34

    MeSH

    Acrylic Resins
    Biocompatible Materials
    Drug Carriers
    Drug Delivery Systems
    Gels
    Materials Testing
    Molecular Structure
    Particle Size
    Temperature
    beta-Cyclodextrins

    Pub Type(s)

    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19107719