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Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice.
Phytother Res 2009; 23(5):701-6PR

Abstract

This study examined the effects of daidzin, a major isoflavone from Puerariae Radix, on D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced liver failure. Mice were given an intraperitoneal injection of daidzin (25, 50, 100 and 200 mg/kg) 1 h before receiving an injection of D-GalN (700 mg/kg)/LPS (10 microg/kg). Daidzin markedly reduced the elevated serum aminotransferase activity and the levels of lipid peroxidation and tumor necrosis factor-alpha. The glutathione content was lower in the D-GalN/LPS group, which was attenuated by daidzin. The daidzin pretreatment attenuated the swollen mitochondria observed in the d-GalN/LPS group. Daidzin attenuated the apoptosis of hepatocytes, which was confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and a caspase-3 assay. Overall, these results suggest that the liver protection of daidzin is due to reduced oxidative stress and its antiapoptotic activity.

Authors+Show Affiliations

College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19107740

Citation

Kim, Sung-Hwa, et al. "Protective Effect of Daidzin Against D-galactosamine and Lipopolysaccharide-induced Hepatic Failure in Mice." Phytotherapy Research : PTR, vol. 23, no. 5, 2009, pp. 701-6.
Kim SH, Heo JH, Kim YS, et al. Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. Phytother Res. 2009;23(5):701-6.
Kim, S. H., Heo, J. H., Kim, Y. S., Kang, S. S., Choi, J. S., & Lee, S. M. (2009). Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. Phytotherapy Research : PTR, 23(5), pp. 701-6. doi:10.1002/ptr.2710.
Kim SH, et al. Protective Effect of Daidzin Against D-galactosamine and Lipopolysaccharide-induced Hepatic Failure in Mice. Phytother Res. 2009;23(5):701-6. PubMed PMID: 19107740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. AU - Kim,Sung-Hwa, AU - Heo,Jeong-Haing, AU - Kim,Yeong Shik, AU - Kang,Sam Sik, AU - Choi,Jae Sue, AU - Lee,Sun-Mee, PY - 2008/12/25/entrez PY - 2008/12/25/pubmed PY - 2009/5/23/medline SP - 701 EP - 6 JF - Phytotherapy research : PTR JO - Phytother Res VL - 23 IS - 5 N2 - This study examined the effects of daidzin, a major isoflavone from Puerariae Radix, on D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced liver failure. Mice were given an intraperitoneal injection of daidzin (25, 50, 100 and 200 mg/kg) 1 h before receiving an injection of D-GalN (700 mg/kg)/LPS (10 microg/kg). Daidzin markedly reduced the elevated serum aminotransferase activity and the levels of lipid peroxidation and tumor necrosis factor-alpha. The glutathione content was lower in the D-GalN/LPS group, which was attenuated by daidzin. The daidzin pretreatment attenuated the swollen mitochondria observed in the d-GalN/LPS group. Daidzin attenuated the apoptosis of hepatocytes, which was confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and a caspase-3 assay. Overall, these results suggest that the liver protection of daidzin is due to reduced oxidative stress and its antiapoptotic activity. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/19107740/Protective_effect_of_daidzin_against_D_galactosamine_and_lipopolysaccharide_induced_hepatic_failure_in_mice_ L2 - https://doi.org/10.1002/ptr.2710 DB - PRIME DP - Unbound Medicine ER -