Tags

Type your tag names separated by a space and hit enter

Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Int J Cancer. 2009 Apr 15; 124(8):1926-34.IJ

Abstract

Many case-control studies have suggested that higher consumption of fruit and vegetables is associated with a lower risk of pancreatic cancer, whereas cohort studies do not support such an association. We examined the associations of the consumption of fruits and vegetables and their main subgroups with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is comprised of over 520,000 subjects recruited from 10 European countries. The present study included 555 exocrine pancreatic cancer cases after an average follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models, stratified by age at recruitment, gender, and study center, and adjusted for total energy intake, weight, height, history of diabetes mellitus, and smoking status. Total consumption of fruit and vegetables, combined or separately, as well as subgroups of vegetables and fruits were unrelated to risk of pancreatic cancer. Hazard ratios (95% CI) for the highest versus the lowest quartile were 0.92 (0.68-1.25) for total fruit and vegetables combined, 0.99 (0.73-1.33) for total vegetables, and 1.02 (0.77-1.36) for total fruits. Stratification by gender or smoking status, restriction to microscopically verified cases, and exclusion of the first 2 years of follow-up did not materially change the results. These results from a large European prospective cohort suggest that higher consumption of fruit and vegetables is not associated with decreased risk of pancreatic cancer.

Authors+Show Affiliations

National Institute for Public Health and the Environment, Bilthoven, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19107929

Citation

Vrieling, Alina, et al. "Fruit and Vegetable Consumption and Pancreatic Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition." International Journal of Cancer, vol. 124, no. 8, 2009, pp. 1926-34.
Vrieling A, Verhage BA, van Duijnhoven FJ, et al. Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2009;124(8):1926-34.
Vrieling, A., Verhage, B. A., van Duijnhoven, F. J., Jenab, M., Overvad, K., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M. C., Kaaks, R., Rohrmann, S., Boeing, H., Nöthlings, U., Trichopoulou, A., John, T., Dimosthenes, Z., Palli, D., Sieri, S., Mattiello, A., ... Bueno-de-Mesquita, H. B. (2009). Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 124(8), 1926-34. https://doi.org/10.1002/ijc.24134
Vrieling A, et al. Fruit and Vegetable Consumption and Pancreatic Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition. Int J Cancer. 2009 Apr 15;124(8):1926-34. PubMed PMID: 19107929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. AU - Vrieling,Alina, AU - Verhage,Bas A J, AU - van Duijnhoven,Fränzel J B, AU - Jenab,Mazda, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Olsen,Anja, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, AU - Kaaks,Rudolf, AU - Rohrmann,Sabine, AU - Boeing,Heiner, AU - Nöthlings,Ute, AU - Trichopoulou,Antonia, AU - John,Tountas, AU - Dimosthenes,Zilis, AU - Palli,Domenico, AU - Sieri,Sabina, AU - Mattiello,Amalia, AU - Tumino,Rosario, AU - Vineis,Paolo, AU - van Gils,Carla H, AU - Peeters,Petra H M, AU - Engeset,Dagrun, AU - Lund,Eiliv, AU - Rodríguez Suárez,Laudina, AU - Jakszyn,Paula, AU - Larrañaga,Nerea, AU - Sánchez,María-José, AU - Chirlaque,María-Dolores, AU - Ardanaz,Eva, AU - Manjer,Jonas, AU - Lindkvist,Björn, AU - Hallmans,Göran, AU - Ye,Weimin, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Roddam,Andrew, AU - Key,Tim, AU - Boffetta,Paolo, AU - Duell,Eric J, AU - Michaud,Dominique S, AU - Riboli,Elio, AU - Bueno-de-Mesquita,H Bas, PY - 2008/12/25/entrez PY - 2008/12/25/pubmed PY - 2009/3/20/medline SP - 1926 EP - 34 JF - International journal of cancer JO - Int. J. Cancer VL - 124 IS - 8 N2 - Many case-control studies have suggested that higher consumption of fruit and vegetables is associated with a lower risk of pancreatic cancer, whereas cohort studies do not support such an association. We examined the associations of the consumption of fruits and vegetables and their main subgroups with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is comprised of over 520,000 subjects recruited from 10 European countries. The present study included 555 exocrine pancreatic cancer cases after an average follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models, stratified by age at recruitment, gender, and study center, and adjusted for total energy intake, weight, height, history of diabetes mellitus, and smoking status. Total consumption of fruit and vegetables, combined or separately, as well as subgroups of vegetables and fruits were unrelated to risk of pancreatic cancer. Hazard ratios (95% CI) for the highest versus the lowest quartile were 0.92 (0.68-1.25) for total fruit and vegetables combined, 0.99 (0.73-1.33) for total vegetables, and 1.02 (0.77-1.36) for total fruits. Stratification by gender or smoking status, restriction to microscopically verified cases, and exclusion of the first 2 years of follow-up did not materially change the results. These results from a large European prospective cohort suggest that higher consumption of fruit and vegetables is not associated with decreased risk of pancreatic cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19107929/Fruit_and_vegetable_consumption_and_pancreatic_cancer_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_ L2 - https://doi.org/10.1002/ijc.24134 DB - PRIME DP - Unbound Medicine ER -