Tags

Type your tag names separated by a space and hit enter

Phenylephrine in the prevention of hypotension following spinal anesthesia for cesarean delivery.
J Clin Anesth. 1991 Jul-Aug; 3(4):301-5.JC

Abstract

STUDY OBJECTIVE

Phenylephrine and ephedrine were compared in the prevention of maternal hypotension following spinal anesthesia for elective cesarean delivery.

DESIGN

Randomized, double-blind trial.

SETTING

Obstetric suite at a university-affiliated hospital.

PATIENTS

Sixty healthy patients electively scheduled for cesarean delivery under spinal anesthesia.

INTERVENTIONS

Patients were randomly assigned to receive either ephedrine (n = 29) in 10 mg intravenous (IV) bolus injections or phenylephrine (n = 31) in 80 microgram IV bolus injections to maintain systolic blood pressure (SBP) above 100 mmHg.

MEASUREMENTS AND MAIN RESULTS

Maternal venous, umbilical artery, and umbilical vein blood gases were measured, and neonatal Apgar scores and Early Neonatal Neurobehavior Scale scores were assessed. In the ephedrine group, umbilical artery pH was 7.28 +/- 0.01 (mean +/- SEM), umbilical artery partial pressure of carbon dioxide (PCO2) was 56.6 +/- 1.4 mmHg, and umbilical artery base deficit was 2.2 +/- 0.04 meq. In the phenylephrine group, umbilical artery pH was 7.32 +/- 0.01, umbilical artery PCO2 was 52.1 +/- 1.3 torr, and umbilical artery base deficit was 0.38 +/- 0.35 meq. There were significant differences between the groups in mean umbilical artery pH, PCO2, and base deficit, although all values obtained were within normal limits. There were no significant differences between the groups in the remaining acid-base values, neonatal Apgar scores, Early Neonatal Neurobehavior Scale scores, or frequency of maternal nausea and vomiting.

CONCLUSIONS

Phenylephrine is as effective as ephedrine in the treatment of maternal hypotension, and when used in small incremental bolus injections, it appears to have no adverse neonatal effects in healthy, nonlaboring parturients.

Authors+Show Affiliations

Department of Anaesthesia, Harvard Medical School, Boston, MA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1910798

Citation

Moran, D H., et al. "Phenylephrine in the Prevention of Hypotension Following Spinal Anesthesia for Cesarean Delivery." Journal of Clinical Anesthesia, vol. 3, no. 4, 1991, pp. 301-5.
Moran DH, Perillo M, LaPorta RF, et al. Phenylephrine in the prevention of hypotension following spinal anesthesia for cesarean delivery. J Clin Anesth. 1991;3(4):301-5.
Moran, D. H., Perillo, M., LaPorta, R. F., Bader, A. M., & Datta, S. (1991). Phenylephrine in the prevention of hypotension following spinal anesthesia for cesarean delivery. Journal of Clinical Anesthesia, 3(4), 301-5.
Moran DH, et al. Phenylephrine in the Prevention of Hypotension Following Spinal Anesthesia for Cesarean Delivery. J Clin Anesth. 1991 Jul-Aug;3(4):301-5. PubMed PMID: 1910798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenylephrine in the prevention of hypotension following spinal anesthesia for cesarean delivery. AU - Moran,D H, AU - Perillo,M, AU - LaPorta,R F, AU - Bader,A M, AU - Datta,S, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 301 EP - 5 JF - Journal of clinical anesthesia JO - J Clin Anesth VL - 3 IS - 4 N2 - STUDY OBJECTIVE: Phenylephrine and ephedrine were compared in the prevention of maternal hypotension following spinal anesthesia for elective cesarean delivery. DESIGN: Randomized, double-blind trial. SETTING: Obstetric suite at a university-affiliated hospital. PATIENTS: Sixty healthy patients electively scheduled for cesarean delivery under spinal anesthesia. INTERVENTIONS: Patients were randomly assigned to receive either ephedrine (n = 29) in 10 mg intravenous (IV) bolus injections or phenylephrine (n = 31) in 80 microgram IV bolus injections to maintain systolic blood pressure (SBP) above 100 mmHg. MEASUREMENTS AND MAIN RESULTS: Maternal venous, umbilical artery, and umbilical vein blood gases were measured, and neonatal Apgar scores and Early Neonatal Neurobehavior Scale scores were assessed. In the ephedrine group, umbilical artery pH was 7.28 +/- 0.01 (mean +/- SEM), umbilical artery partial pressure of carbon dioxide (PCO2) was 56.6 +/- 1.4 mmHg, and umbilical artery base deficit was 2.2 +/- 0.04 meq. In the phenylephrine group, umbilical artery pH was 7.32 +/- 0.01, umbilical artery PCO2 was 52.1 +/- 1.3 torr, and umbilical artery base deficit was 0.38 +/- 0.35 meq. There were significant differences between the groups in mean umbilical artery pH, PCO2, and base deficit, although all values obtained were within normal limits. There were no significant differences between the groups in the remaining acid-base values, neonatal Apgar scores, Early Neonatal Neurobehavior Scale scores, or frequency of maternal nausea and vomiting. CONCLUSIONS: Phenylephrine is as effective as ephedrine in the treatment of maternal hypotension, and when used in small incremental bolus injections, it appears to have no adverse neonatal effects in healthy, nonlaboring parturients. SN - 0952-8180 UR - https://www.unboundmedicine.com/medline/citation/1910798/Phenylephrine_in_the_prevention_of_hypotension_following_spinal_anesthesia_for_cesarean_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0952-8180(91)90224-B DB - PRIME DP - Unbound Medicine ER -