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Bone marrow necrosis preceding infantile acute lymphoblastic leukaemia.
Malays J Pathol. 2007 Dec; 29(2):113-7.MJ

Abstract

We report a case of bone marrow necrosis preceding infantile acute lymphoblastic leukaemia (ALL). Bone marrow necrosis is a rare antemortem event and has been known to be present in many conditions, notably in haematological malignancies like acute lymphoblastic leukaemia. This case was a 6-month-old Chinese boy who was referred to Hospital Universiti Kebangsaan Malaysia for further investigation of pancytopaenia, high-grade fever, bloody diarrhoea and petechial rashes for one week. His first bone marrow aspirate revealed bone marrow necrosis. His clinical condition improved after ten days. However, his full blood picture then revealed the presence of 5% blast cells. His subsequent marrow 2 weeks later revealed acute lymphoblastic leukaemia (FAB-L1) and immunophenotyping showed precursor B acute lymphoblastic leukaemia-null type. He was started on United Kingdom Acute Lymphoblastic leukaemia (UK ALL) Infantile Leukaemia protocol, however, he defaulted treatment after 3 days. Mode of presentation, mechanism of disease and laboratory investigations and outline of treatment will be discussed.

Authors+Show Affiliations

Department of Pathology, Faculty of Medicine & Health Sciences, University Putra Malaysia, Selangor, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19108404

Citation

Eusni, Rahayu Mohd Tohit, et al. "Bone Marrow Necrosis Preceding Infantile Acute Lymphoblastic Leukaemia." The Malaysian Journal of Pathology, vol. 29, no. 2, 2007, pp. 113-7.
Eusni RM, Hamidah Hussin N, Zarina AL, et al. Bone marrow necrosis preceding infantile acute lymphoblastic leukaemia. Malays J Pathol. 2007;29(2):113-7.
Eusni, R. M., Hamidah Hussin, N., Zarina, A. L., & Rahman, J. (2007). Bone marrow necrosis preceding infantile acute lymphoblastic leukaemia. The Malaysian Journal of Pathology, 29(2), 113-7.
Eusni RM, et al. Bone Marrow Necrosis Preceding Infantile Acute Lymphoblastic Leukaemia. Malays J Pathol. 2007;29(2):113-7. PubMed PMID: 19108404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone marrow necrosis preceding infantile acute lymphoblastic leukaemia. AU - Eusni,Rahayu Mohd Tohit, AU - Hamidah Hussin,Noor, AU - Zarina,Abd Latiff, AU - Rahman,Jamal, PY - 2008/12/26/entrez PY - 2008/12/26/pubmed PY - 2009/2/4/medline SP - 113 EP - 7 JF - The Malaysian journal of pathology JO - Malays J Pathol VL - 29 IS - 2 N2 - We report a case of bone marrow necrosis preceding infantile acute lymphoblastic leukaemia (ALL). Bone marrow necrosis is a rare antemortem event and has been known to be present in many conditions, notably in haematological malignancies like acute lymphoblastic leukaemia. This case was a 6-month-old Chinese boy who was referred to Hospital Universiti Kebangsaan Malaysia for further investigation of pancytopaenia, high-grade fever, bloody diarrhoea and petechial rashes for one week. His first bone marrow aspirate revealed bone marrow necrosis. His clinical condition improved after ten days. However, his full blood picture then revealed the presence of 5% blast cells. His subsequent marrow 2 weeks later revealed acute lymphoblastic leukaemia (FAB-L1) and immunophenotyping showed precursor B acute lymphoblastic leukaemia-null type. He was started on United Kingdom Acute Lymphoblastic leukaemia (UK ALL) Infantile Leukaemia protocol, however, he defaulted treatment after 3 days. Mode of presentation, mechanism of disease and laboratory investigations and outline of treatment will be discussed. SN - 0126-8635 UR - https://www.unboundmedicine.com/medline/citation/19108404/Bone_marrow_necrosis_preceding_infantile_acute_lymphoblastic_leukaemia_ L2 - http://www.mjpath.org.my/2007.2/09BM.pdf DB - PRIME DP - Unbound Medicine ER -