Tags

Type your tag names separated by a space and hit enter

Prostate-specific antigen in breast disease.
Malays J Pathol. 2008 Jun; 30(1):43-51.MJ

Abstract

The aim of this study is to assess tissue and serum prostate-specific antigen (PSA) in breast lesions; to compare tissue PSA with serum PSA; to compare tissue PSA in benign and malignant lesions and to compare PSA with known prognostic factors in breast carcinoma. Tissue PSA immunoreactivity in twenty women with breast carcinoma was compared with PSA in twenty-three women with benign breast lesions. Tissue PSA was also compared with known prognostic indicators such as tumour size, axillary nodal status, histological type, histological grade, oestrogen receptor status, progesterone receptor status and c-erbB-2 oncoprotein over-expression. Serum free PSAlevels from these women were measured pre- and post-operatively and an attempt was made to correlate serum PSA with tissue PSA expression. 40% and 43% of malignant and benign breast lesions respectively showed tissue PSA immunoreactivity. No significant difference was observed in the tissue PSA expression between these two groups as also between tissue PSA and known prognostic indicators. As serum PSA levels were below the detection limit (< 0.004 ng/ml) in all except two benign cases, no statistical evaluation was done for the latter. Tissue PSA expression did not correlate with other prognostic markers and detectable serum PSA levels were present in too few cases for statistical analysis. Although no definitive conclusion is possible in this preliminary study regarding the role of PSA in breast disease, it stimulates interest in further research in this direction.

Authors+Show Affiliations

Department of Pathology, Faculty of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia. pohbh73@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19108411

Citation

Poh, Bee Hoon, et al. "Prostate-specific Antigen in Breast Disease." The Malaysian Journal of Pathology, vol. 30, no. 1, 2008, pp. 43-51.
Poh BH, Jayaram G, Sthaneshwar P, et al. Prostate-specific antigen in breast disease. Malays J Pathol. 2008;30(1):43-51.
Poh, B. H., Jayaram, G., Sthaneshwar, P., & Yip, C. H. (2008). Prostate-specific antigen in breast disease. The Malaysian Journal of Pathology, 30(1), 43-51.
Poh BH, et al. Prostate-specific Antigen in Breast Disease. Malays J Pathol. 2008;30(1):43-51. PubMed PMID: 19108411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostate-specific antigen in breast disease. AU - Poh,Bee Hoon, AU - Jayaram,Gita, AU - Sthaneshwar,Pavai, AU - Yip,Cheng Har, PY - 2008/12/26/entrez PY - 2008/12/26/pubmed PY - 2009/2/4/medline SP - 43 EP - 51 JF - The Malaysian journal of pathology JO - Malays J Pathol VL - 30 IS - 1 N2 - The aim of this study is to assess tissue and serum prostate-specific antigen (PSA) in breast lesions; to compare tissue PSA with serum PSA; to compare tissue PSA in benign and malignant lesions and to compare PSA with known prognostic factors in breast carcinoma. Tissue PSA immunoreactivity in twenty women with breast carcinoma was compared with PSA in twenty-three women with benign breast lesions. Tissue PSA was also compared with known prognostic indicators such as tumour size, axillary nodal status, histological type, histological grade, oestrogen receptor status, progesterone receptor status and c-erbB-2 oncoprotein over-expression. Serum free PSAlevels from these women were measured pre- and post-operatively and an attempt was made to correlate serum PSA with tissue PSA expression. 40% and 43% of malignant and benign breast lesions respectively showed tissue PSA immunoreactivity. No significant difference was observed in the tissue PSA expression between these two groups as also between tissue PSA and known prognostic indicators. As serum PSA levels were below the detection limit (< 0.004 ng/ml) in all except two benign cases, no statistical evaluation was done for the latter. Tissue PSA expression did not correlate with other prognostic markers and detectable serum PSA levels were present in too few cases for statistical analysis. Although no definitive conclusion is possible in this preliminary study regarding the role of PSA in breast disease, it stimulates interest in further research in this direction. SN - 0126-8635 UR - https://www.unboundmedicine.com/medline/citation/19108411/Prostate_specific_antigen_in_breast_disease_ L2 - http://www.mjpath.org.my/2008.1/07_Prostate-specific_antigen_in_breast_disease.pdf DB - PRIME DP - Unbound Medicine ER -