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Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III.
Bioorg Med Chem Lett. 2009 Feb 01; 19(3):800-2.BM

Abstract

High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, structure-activity relationships and functional activity are described.

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Authors+Show Affiliations

Guiles J
Replidyne, Inc., 1450 Infinite Dr., Louisville, CO 80027, USA. joe.guiles@comcast.net
Sun X
No affiliation info available
Critchley IA
No affiliation info available
Ochsner U
No affiliation info available
Tregay M
No affiliation info available
Stone K
No affiliation info available
Bertino J
No affiliation info available
Green L
No affiliation info available
Sabin R
No affiliation info available
Dean F
No affiliation info available
Dallmann HG
No affiliation info available
McHenry CS
No affiliation info available
Janjic N
No affiliation info available

MeSH

Cell DeathChemistry, PharmaceuticalDNADNA Polymerase IIIDrug DesignDrug Evaluation, PreclinicalEnzyme InhibitorsHumansModels, BiologicalModels, ChemicalMolecular StructureQuinazolinesStreptococcus pyogenesStructure-Activity Relationship

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19109016

Citation

Guiles, Joseph, et al. "Quinazolin-2-ylamino-quinazolin-4-ols as Novel Non-nucleoside Inhibitors of Bacterial DNA Polymerase III." Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 3, 2009, pp. 800-2.
Guiles J, Sun X, Critchley IA, et al. Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III. Bioorg Med Chem Lett. 2009;19(3):800-2.
Guiles, J., Sun, X., Critchley, I. A., Ochsner, U., Tregay, M., Stone, K., Bertino, J., Green, L., Sabin, R., Dean, F., Dallmann, H. G., McHenry, C. S., & Janjic, N. (2009). Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III. Bioorganic & Medicinal Chemistry Letters, 19(3), 800-2. https://doi.org/10.1016/j.bmcl.2008.12.038
Guiles J, et al. Quinazolin-2-ylamino-quinazolin-4-ols as Novel Non-nucleoside Inhibitors of Bacterial DNA Polymerase III. Bioorg Med Chem Lett. 2009 Feb 1;19(3):800-2. PubMed PMID: 19109016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III. AU - Guiles,Joseph, AU - Sun,Xicheng, AU - Critchley,Ian A, AU - Ochsner,Urs, AU - Tregay,Ming, AU - Stone,Kim, AU - Bertino,Jennifer, AU - Green,Louis, AU - Sabin,Rob, AU - Dean,Frank, AU - Dallmann,H Garry, AU - McHenry,Charles S, AU - Janjic,Nebojsa, Y1 - 2008/12/13/ PY - 2008/08/14/received PY - 2008/12/03/revised PY - 2008/12/04/accepted PY - 2008/12/26/entrez PY - 2008/12/26/pubmed PY - 2010/7/7/medline SP - 800 EP - 2 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 19 IS - 3 N2 - High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, structure-activity relationships and functional activity are described. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/19109016/Quinazolin_2_ylamino_quinazolin_4_ols_as_novel_non_nucleoside_inhibitors_of_bacterial_DNA_polymerase_III_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(08)01532-1 DB - PRIME DP - Unbound Medicine ER -