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Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia.
Clin Neurophysiol. 2009 Feb; 120(2):257-63.CN

Abstract

OBJECTIVE

The aim of this study was to evaluate quantitatively the presence and the characteristics of periodic leg movements during sleep (PLMS) in a group of consecutive patients presenting with daytime impairment related to insomnia of unknown etiology and whose polysomnographic features differ from those of healthy individuals only for a significantly increased arousal index in NREM sleep.

METHODS

We recruited 20 consecutive adult patients with insomnia according to the ICSD-2 criteria, 20 patients with RLS, and 12 age-matched normal controls. The time structure of their polysomnographically recorded leg movements during sleep was analyzed by means of an approach particularly able to consider their periodicity.

RESULTS

A subgroup of 12 patients with a relatively high number of periodic LM activity was detected with a statistically based approach using two indexes: total LM index and Periodicity index. This subgroup had high PLMS index, Periodicity index was also high and PLMS showed a progressive decrease during the night, being highest in the first hours of sleep. The characteristics of PLMS were identical within this insomnia subgroup and RLS patients.

CONCLUSIONS

PLMS was a common finding in our patients with insomnia and a detailed analysis of their periodicity revealed that a subgroup of these patients had to be finally diagnosed with Periodic Limb Movement Disorder.

SIGNIFICANCE

Polysomnography with the subsequent analysis of PLMS periodicity is able to differentiate between insomnia patient subgroups.

Authors+Show Affiliations

Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Via C. Ruggero 73, 94018 Troina, Italy. rferri@oasi.en.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19109055

Citation

Ferri, Raffaele, et al. "Periodic Leg Movements During Sleep and Periodic Limb Movement Disorder in Patients Presenting With Unexplained Insomnia." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 120, no. 2, 2009, pp. 257-63.
Ferri R, Gschliesser V, Frauscher B, et al. Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia. Clin Neurophysiol. 2009;120(2):257-63.
Ferri, R., Gschliesser, V., Frauscher, B., Poewe, W., & Högl, B. (2009). Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 120(2), 257-63. https://doi.org/10.1016/j.clinph.2008.11.006
Ferri R, et al. Periodic Leg Movements During Sleep and Periodic Limb Movement Disorder in Patients Presenting With Unexplained Insomnia. Clin Neurophysiol. 2009;120(2):257-63. PubMed PMID: 19109055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia. AU - Ferri,Raffaele, AU - Gschliesser,Viola, AU - Frauscher,Birgit, AU - Poewe,Werner, AU - Högl,Birgit, Y1 - 2008/12/23/ PY - 2008/06/10/received PY - 2008/11/12/revised PY - 2008/11/15/accepted PY - 2008/12/26/entrez PY - 2008/12/26/pubmed PY - 2009/4/9/medline SP - 257 EP - 63 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 120 IS - 2 N2 - OBJECTIVE: The aim of this study was to evaluate quantitatively the presence and the characteristics of periodic leg movements during sleep (PLMS) in a group of consecutive patients presenting with daytime impairment related to insomnia of unknown etiology and whose polysomnographic features differ from those of healthy individuals only for a significantly increased arousal index in NREM sleep. METHODS: We recruited 20 consecutive adult patients with insomnia according to the ICSD-2 criteria, 20 patients with RLS, and 12 age-matched normal controls. The time structure of their polysomnographically recorded leg movements during sleep was analyzed by means of an approach particularly able to consider their periodicity. RESULTS: A subgroup of 12 patients with a relatively high number of periodic LM activity was detected with a statistically based approach using two indexes: total LM index and Periodicity index. This subgroup had high PLMS index, Periodicity index was also high and PLMS showed a progressive decrease during the night, being highest in the first hours of sleep. The characteristics of PLMS were identical within this insomnia subgroup and RLS patients. CONCLUSIONS: PLMS was a common finding in our patients with insomnia and a detailed analysis of their periodicity revealed that a subgroup of these patients had to be finally diagnosed with Periodic Limb Movement Disorder. SIGNIFICANCE: Polysomnography with the subsequent analysis of PLMS periodicity is able to differentiate between insomnia patient subgroups. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/19109055/Periodic_leg_movements_during_sleep_and_periodic_limb_movement_disorder_in_patients_presenting_with_unexplained_insomnia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(08)01257-1 DB - PRIME DP - Unbound Medicine ER -