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A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis.
Arthroscopy 2009; 25(1):86-94A

Abstract

The investigation of disease-modifying treatment options for osteoarthritis (OA) has become an important aspect of orthopaedic care. The purpose of this review is to critically evaluate the evidence for the use of glucosamine and chondroitin sulfate for knee OA with the goal of elucidating their indications for clinical use. The published clinical studies of glucosamine and chondroitin sulfate on OA are reviewed within the context of evidence-based medicine. Almost every included trial has found the safety of these compounds to be equal to placebo. In the literature satisfying our inclusion criteria, glucosamine sulfate, glucosamine hydrochloride, and chondroitin sulfate have individually shown inconsistent efficacy in decreasing OA pain and improving joint function. Many studies confirmed OA pain relief with glucosamine and chondroitin sulfate use. The excellent safety profile of glucosamine and chondroitin sulfate therapy should be discussed with patients, and these supplements may serve a role as an initial treatment modality for many OA patients.

Authors+Show Affiliations

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. vangsness@usc.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19111223

Citation

Vangsness, C Thomas, et al. "A Review of Evidence-based Medicine for Glucosamine and Chondroitin Sulfate Use in Knee Osteoarthritis." Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association, vol. 25, no. 1, 2009, pp. 86-94.
Vangsness CT, Spiker W, Erickson J. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy. 2009;25(1):86-94.
Vangsness, C. T., Spiker, W., & Erickson, J. (2009). A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 25(1), pp. 86-94. doi:10.1016/j.arthro.2008.07.020.
Vangsness CT, Spiker W, Erickson J. A Review of Evidence-based Medicine for Glucosamine and Chondroitin Sulfate Use in Knee Osteoarthritis. Arthroscopy. 2009;25(1):86-94. PubMed PMID: 19111223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. AU - Vangsness,C Thomas,Jr AU - Spiker,William, AU - Erickson,Juliana, Y1 - 2008/09/30/ PY - 2007/05/15/received PY - 2008/07/08/revised PY - 2008/07/09/accepted PY - 2008/12/30/entrez PY - 2008/12/30/pubmed PY - 2009/3/25/medline SP - 86 EP - 94 JF - Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association JO - Arthroscopy VL - 25 IS - 1 N2 - The investigation of disease-modifying treatment options for osteoarthritis (OA) has become an important aspect of orthopaedic care. The purpose of this review is to critically evaluate the evidence for the use of glucosamine and chondroitin sulfate for knee OA with the goal of elucidating their indications for clinical use. The published clinical studies of glucosamine and chondroitin sulfate on OA are reviewed within the context of evidence-based medicine. Almost every included trial has found the safety of these compounds to be equal to placebo. In the literature satisfying our inclusion criteria, glucosamine sulfate, glucosamine hydrochloride, and chondroitin sulfate have individually shown inconsistent efficacy in decreasing OA pain and improving joint function. Many studies confirmed OA pain relief with glucosamine and chondroitin sulfate use. The excellent safety profile of glucosamine and chondroitin sulfate therapy should be discussed with patients, and these supplements may serve a role as an initial treatment modality for many OA patients. SN - 1526-3231 UR - https://www.unboundmedicine.com/medline/citation/19111223/A_review_of_evidence_based_medicine_for_glucosamine_and_chondroitin_sulfate_use_in_knee_osteoarthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0749-8063(08)00589-6 DB - PRIME DP - Unbound Medicine ER -