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Amyloid beta concentrations in older people with Down syndrome and dementia.
Neurosci Lett. 2009 Feb 20; 451(2):162-4.NL

Abstract

People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon Abeta1-40 or Abeta1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population.

Authors+Show Affiliations

Wolfson Centre for Age-related Disease, Wolfson CARD, Guy's Campus, King's College London, London SE1 1UL, United Kingdom. emma.3.jones@kcl.ac.uk <emma.3.jones@kcl.ac.uk>No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19111900

Citation

Jones, Emma L., et al. "Amyloid Beta Concentrations in Older People With Down Syndrome and Dementia." Neuroscience Letters, vol. 451, no. 2, 2009, pp. 162-4.
Jones EL, Hanney M, Francis PT, et al. Amyloid beta concentrations in older people with Down syndrome and dementia. Neurosci Lett. 2009;451(2):162-4.
Jones, E. L., Hanney, M., Francis, P. T., & Ballard, C. G. (2009). Amyloid beta concentrations in older people with Down syndrome and dementia. Neuroscience Letters, 451(2), 162-4. https://doi.org/10.1016/j.neulet.2008.12.030
Jones EL, et al. Amyloid Beta Concentrations in Older People With Down Syndrome and Dementia. Neurosci Lett. 2009 Feb 20;451(2):162-4. PubMed PMID: 19111900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amyloid beta concentrations in older people with Down syndrome and dementia. AU - Jones,Emma L, AU - Hanney,Marisa, AU - Francis,Paul T, AU - Ballard,Clive G, Y1 - 2008/12/24/ PY - 2008/11/12/received PY - 2008/12/16/revised PY - 2008/12/17/accepted PY - 2008/12/30/entrez PY - 2008/12/30/pubmed PY - 2009/4/10/medline SP - 162 EP - 4 JF - Neuroscience letters JO - Neurosci Lett VL - 451 IS - 2 N2 - People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon Abeta1-40 or Abeta1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/19111900/Amyloid_beta_concentrations_in_older_people_with_Down_syndrome_and_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)01727-8 DB - PRIME DP - Unbound Medicine ER -