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Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract.
J Ethnopharmacol. 2009 Feb 25; 122(1):86-90.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Parquetina nigrescens is a shrub that is commonly used in different parts of West Africa for the treatment of several ailments which includes pain, fever and inflammatory conditions.

AIM OF THE STUDY

The present study was designed to investigate the analgesic, anti-inflammatory and antipyretic effects of the aqueous extract of Parquetina nigrescens leaves in rats.

MATERIALS AND METHODS

Five groups were used for each study, groups 1 and 5 served as control (saline) and reference (indomethacine) respectively, while groups 2-4 received the extract (50-200 mg/kg) orally. Formalin paw licking and hot plate latency tests were used for analgesic studies. Carrageenan oedema, cotton pellet granuloma and formaldehyde arthritis models were used to quantify the anti-inflammatory activities while the brewer's yeast was used for inducing pyrexia.

RESULTS

The results of the analgesic study show that the extract produced significant (p<0.05) analgesia in the hot plate and in the formalin tests. In the anti-inflammatory study, Parquetina nigrescens produced significant (p<0.05) inhibition of the various types of inflammation. The extract also inhibited the pyrexia induced by brewer's yeast.

CONCLUSION

The result justifies the traditional uses of Parquetina nigrescens for the treatment of fever, inflammatory and painful conditions.

Authors+Show Affiliations

Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria. deleyele@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19111918

Citation

Owoyele, Bamidele V., et al. "Studies On the Analgesic, Anti-inflammatory and Antipyretic Effects of Parquetina Nigrescens Leaf Extract." Journal of Ethnopharmacology, vol. 122, no. 1, 2009, pp. 86-90.
Owoyele BV, Nafiu AB, Oyewole IA, et al. Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract. J Ethnopharmacol. 2009;122(1):86-90.
Owoyele, B. V., Nafiu, A. B., Oyewole, I. A., Oyewole, L. A., & Soladoye, A. O. (2009). Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract. Journal of Ethnopharmacology, 122(1), 86-90. https://doi.org/10.1016/j.jep.2008.11.027
Owoyele BV, et al. Studies On the Analgesic, Anti-inflammatory and Antipyretic Effects of Parquetina Nigrescens Leaf Extract. J Ethnopharmacol. 2009 Feb 25;122(1):86-90. PubMed PMID: 19111918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract. AU - Owoyele,Bamidele V, AU - Nafiu,Abdulrazaq B, AU - Oyewole,Idris A, AU - Oyewole,Lukuman A, AU - Soladoye,Ayodele O, Y1 - 2008/12/07/ PY - 2008/07/07/received PY - 2008/09/18/revised PY - 2008/11/27/accepted PY - 2008/12/30/entrez PY - 2008/12/30/pubmed PY - 2009/6/10/medline SP - 86 EP - 90 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 122 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Parquetina nigrescens is a shrub that is commonly used in different parts of West Africa for the treatment of several ailments which includes pain, fever and inflammatory conditions. AIM OF THE STUDY: The present study was designed to investigate the analgesic, anti-inflammatory and antipyretic effects of the aqueous extract of Parquetina nigrescens leaves in rats. MATERIALS AND METHODS: Five groups were used for each study, groups 1 and 5 served as control (saline) and reference (indomethacine) respectively, while groups 2-4 received the extract (50-200 mg/kg) orally. Formalin paw licking and hot plate latency tests were used for analgesic studies. Carrageenan oedema, cotton pellet granuloma and formaldehyde arthritis models were used to quantify the anti-inflammatory activities while the brewer's yeast was used for inducing pyrexia. RESULTS: The results of the analgesic study show that the extract produced significant (p<0.05) analgesia in the hot plate and in the formalin tests. In the anti-inflammatory study, Parquetina nigrescens produced significant (p<0.05) inhibition of the various types of inflammation. The extract also inhibited the pyrexia induced by brewer's yeast. CONCLUSION: The result justifies the traditional uses of Parquetina nigrescens for the treatment of fever, inflammatory and painful conditions. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19111918/Studies_on_the_analgesic_anti_inflammatory_and_antipyretic_effects_of_Parquetina_nigrescens_leaf_extract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00663-6 DB - PRIME DP - Unbound Medicine ER -