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Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection.
Brain Dev. 2009 Nov; 31(10):731-8.BD

Abstract

Human herpesvirus-6 (HHV-6) is a causative agent of exanthema subitum. The immunological pathogenesis of acute encephalopathy associated with HHV-6 infection is still unclear. We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in serum and cerebrospinal fluid (CSF) during the acute stage in 15 infants with acute encephalopathy and 12 with febrile seizures associated with HHV-6 infection. The serum IL-6, IL-10, sTNFR1, CSF IL-6, and sTNFR1 levels of infants with encephalopathy who had neurological sequelae (n=9) were significantly higher than those with febrile seizures (p=0.011, 0.043, 0.002, 0.029, and 0.005, respectively). In acute encephalopathy, serum IL-6, sTNFR1, and CSF IL-6 levels in infants with neurological sequelae were significantly higher than those without (n=6) neurological sequelae (p=0.043, 0.026, and 0.029, respectively), and serum IFN-gamma, IL-6, IL-10, and sTNFR1 levels were significantly higher than those in the CSF (p=0.037, 0.037, 0.001, and 0.021, respectively). There were no significant differences in serum or CSF cytokine levels between infants who were positive for HHV-6 DNA in the CSF (n=6) compared to those who were negative (n=9). We suggest that cytokines mediate the pathogenesis of acute encephalopathy associated with HHV-6 infection, and that the elevated levels of serum IL-6, sTNFR1, and CSF IL-6 are important for predicting neurological sequelae.

Authors+Show Affiliations

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. ichiyama@yamaguchi-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19114298

Citation

Ichiyama, Takashi, et al. "Serum and Cerebrospinal Fluid Levels of Cytokines in Acute Encephalopathy Associated With Human Herpesvirus-6 Infection." Brain & Development, vol. 31, no. 10, 2009, pp. 731-8.
Ichiyama T, Ito Y, Kubota M, et al. Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection. Brain Dev. 2009;31(10):731-8.
Ichiyama, T., Ito, Y., Kubota, M., Yamazaki, T., Nakamura, K., & Furukawa, S. (2009). Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection. Brain & Development, 31(10), 731-8. https://doi.org/10.1016/j.braindev.2008.11.005
Ichiyama T, et al. Serum and Cerebrospinal Fluid Levels of Cytokines in Acute Encephalopathy Associated With Human Herpesvirus-6 Infection. Brain Dev. 2009;31(10):731-8. PubMed PMID: 19114298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection. AU - Ichiyama,Takashi, AU - Ito,Yoshinori, AU - Kubota,Masaya, AU - Yamazaki,Tsutomu, AU - Nakamura,Kazuyuki, AU - Furukawa,Susumu, Y1 - 2008/12/27/ PY - 2008/04/21/received PY - 2008/11/17/revised PY - 2008/11/17/accepted PY - 2008/12/31/entrez PY - 2008/12/31/pubmed PY - 2009/11/18/medline SP - 731 EP - 8 JF - Brain & development JO - Brain Dev VL - 31 IS - 10 N2 - Human herpesvirus-6 (HHV-6) is a causative agent of exanthema subitum. The immunological pathogenesis of acute encephalopathy associated with HHV-6 infection is still unclear. We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in serum and cerebrospinal fluid (CSF) during the acute stage in 15 infants with acute encephalopathy and 12 with febrile seizures associated with HHV-6 infection. The serum IL-6, IL-10, sTNFR1, CSF IL-6, and sTNFR1 levels of infants with encephalopathy who had neurological sequelae (n=9) were significantly higher than those with febrile seizures (p=0.011, 0.043, 0.002, 0.029, and 0.005, respectively). In acute encephalopathy, serum IL-6, sTNFR1, and CSF IL-6 levels in infants with neurological sequelae were significantly higher than those without (n=6) neurological sequelae (p=0.043, 0.026, and 0.029, respectively), and serum IFN-gamma, IL-6, IL-10, and sTNFR1 levels were significantly higher than those in the CSF (p=0.037, 0.037, 0.001, and 0.021, respectively). There were no significant differences in serum or CSF cytokine levels between infants who were positive for HHV-6 DNA in the CSF (n=6) compared to those who were negative (n=9). We suggest that cytokines mediate the pathogenesis of acute encephalopathy associated with HHV-6 infection, and that the elevated levels of serum IL-6, sTNFR1, and CSF IL-6 are important for predicting neurological sequelae. SN - 1872-7131 UR - https://www.unboundmedicine.com/medline/citation/19114298/Serum_and_cerebrospinal_fluid_levels_of_cytokines_in_acute_encephalopathy_associated_with_human_herpesvirus_6_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0387-7604(08)00262-3 DB - PRIME DP - Unbound Medicine ER -