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Pitted red cell counts in Nigerian children with sickle cell anaemia: correlation with age and splenic size.
West Afr J Med 1991 Apr-Jun; 10(2):137-40WA

Abstract

Pit counts, using direct interference phase-contrast microscopy (Normansky Optics) were carried out on 32 HbSS patients, aged 3-17 years. The influence of age and splenic size on the counts was also investigated. Nine (9) HbAS and HbAA age and sex-matched, healthy individuals served as controls. The mean +/- SD counts in the 3 groups were 11.1 +/- 9.1%, 1.7 +/- 1.4% and 1.8 +/- 1.7% respectively. The older SS patients tended to have higher values, but the linear correlation with age was not impressive (r = 0.28). Seventeen (53.1%) of the patients had counts in excess of 10%, while 8 (25%) had less than 3.5%. Five patients who had gross splenomegaly had a mean count of 4.3 +/- 1.9%, which was significantly lower than the figure of 12.3 +/- 7.9% for the patients without splenomeglay (p less than 0.001), thus demonstrating retained reticuloendothelial function in such patients.

Authors+Show Affiliations

Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1911481

Citation

Adekile, A D., et al. "Pitted Red Cell Counts in Nigerian Children With Sickle Cell Anaemia: Correlation With Age and Splenic Size." West African Journal of Medicine, vol. 10, no. 2, 1991, pp. 137-40.
Adekile AD, Adeodu RO, Johnson W, et al. Pitted red cell counts in Nigerian children with sickle cell anaemia: correlation with age and splenic size. West Afr J Med. 1991;10(2):137-40.
Adekile, A. D., Adeodu, R. O., Johnson, W., & Dairo, B. A. (1991). Pitted red cell counts in Nigerian children with sickle cell anaemia: correlation with age and splenic size. West African Journal of Medicine, 10(2), pp. 137-40.
Adekile AD, et al. Pitted Red Cell Counts in Nigerian Children With Sickle Cell Anaemia: Correlation With Age and Splenic Size. West Afr J Med. 1991;10(2):137-40. PubMed PMID: 1911481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pitted red cell counts in Nigerian children with sickle cell anaemia: correlation with age and splenic size. AU - Adekile,A D, AU - Adeodu,R O, AU - Johnson,W, AU - Dairo,B A, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 137 EP - 40 JF - West African journal of medicine JO - West Afr J Med VL - 10 IS - 2 N2 - Pit counts, using direct interference phase-contrast microscopy (Normansky Optics) were carried out on 32 HbSS patients, aged 3-17 years. The influence of age and splenic size on the counts was also investigated. Nine (9) HbAS and HbAA age and sex-matched, healthy individuals served as controls. The mean +/- SD counts in the 3 groups were 11.1 +/- 9.1%, 1.7 +/- 1.4% and 1.8 +/- 1.7% respectively. The older SS patients tended to have higher values, but the linear correlation with age was not impressive (r = 0.28). Seventeen (53.1%) of the patients had counts in excess of 10%, while 8 (25%) had less than 3.5%. Five patients who had gross splenomegaly had a mean count of 4.3 +/- 1.9%, which was significantly lower than the figure of 12.3 +/- 7.9% for the patients without splenomeglay (p less than 0.001), thus demonstrating retained reticuloendothelial function in such patients. SN - 0189-160X UR - https://www.unboundmedicine.com/medline/citation/1911481/Pitted_red_cell_counts_in_Nigerian_children_with_sickle_cell_anaemia:_correlation_with_age_and_splenic_size_ DB - PRIME DP - Unbound Medicine ER -