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Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II).
Cancer Causes Control. 2009 Jul; 20(5):741-50.CC

Abstract

OBJECTIVE

The association between metabolic factors and hepatocellular carcinoma (HCC) has not been well clarified. We prospectively examined whether metabolic factors predicts the subsequent risk of HCC in the Japan Public Health Center-based Prospective Study Cohort II, in consideration of hepatitis virus infection status.

METHODS

A total of 17,590 subjects aged 40-69 participating in a questionnaire and health checkup survey during 1993-1994 were followed for incidence of HCC through 2006. A total of 102 cases of HCC were newly documented. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for metabolic factors controlling for potential confounding factors.

RESULTS

The presence of metabolic factors in the aggregate was associated with a significantly increased risk of HCC, especially with hepatitis virus infection. HCC was positively associated particularly with high glucose (HR = 1.75, CI = 1.11-2.74) and overweight (HR = 2.22, CI = 1.42-3.48). Results were similar when analyses were limited to subjects with HCV infection.

CONCLUSIONS

Although metabolic factors in the aggregate may be associated with an increased risk of HCC, the main contributors to this association under HCV infection appear to be overweight and high glucose. Improvement of these factors may be a crucial target in preventing progression to HCC in those with HCV infection.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. mnminoue@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19115074

Citation

Inoue, Manami, et al. "Metabolic Factors and Subsequent Risk of Hepatocellular Carcinoma By Hepatitis Virus Infection Status: a Large-scale Population-based Cohort Study of Japanese Men and Women (JPHC Study Cohort II)." Cancer Causes & Control : CCC, vol. 20, no. 5, 2009, pp. 741-50.
Inoue M, Kurahashi N, Iwasaki M, et al. Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II). Cancer Causes Control. 2009;20(5):741-50.
Inoue, M., Kurahashi, N., Iwasaki, M., Tanaka, Y., Mizokami, M., Noda, M., & Tsugane, S. (2009). Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II). Cancer Causes & Control : CCC, 20(5), 741-50. https://doi.org/10.1007/s10552-008-9287-6
Inoue M, et al. Metabolic Factors and Subsequent Risk of Hepatocellular Carcinoma By Hepatitis Virus Infection Status: a Large-scale Population-based Cohort Study of Japanese Men and Women (JPHC Study Cohort II). Cancer Causes Control. 2009;20(5):741-50. PubMed PMID: 19115074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II). AU - Inoue,Manami, AU - Kurahashi,Norie, AU - Iwasaki,Motoki, AU - Tanaka,Yasuhito, AU - Mizokami,Masashi, AU - Noda,Mitsuhiko, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2008/12/30/ PY - 2008/09/30/received PY - 2008/12/10/accepted PY - 2008/12/31/entrez PY - 2008/12/31/pubmed PY - 2009/9/16/medline SP - 741 EP - 50 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 20 IS - 5 N2 - OBJECTIVE: The association between metabolic factors and hepatocellular carcinoma (HCC) has not been well clarified. We prospectively examined whether metabolic factors predicts the subsequent risk of HCC in the Japan Public Health Center-based Prospective Study Cohort II, in consideration of hepatitis virus infection status. METHODS: A total of 17,590 subjects aged 40-69 participating in a questionnaire and health checkup survey during 1993-1994 were followed for incidence of HCC through 2006. A total of 102 cases of HCC were newly documented. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for metabolic factors controlling for potential confounding factors. RESULTS: The presence of metabolic factors in the aggregate was associated with a significantly increased risk of HCC, especially with hepatitis virus infection. HCC was positively associated particularly with high glucose (HR = 1.75, CI = 1.11-2.74) and overweight (HR = 2.22, CI = 1.42-3.48). Results were similar when analyses were limited to subjects with HCV infection. CONCLUSIONS: Although metabolic factors in the aggregate may be associated with an increased risk of HCC, the main contributors to this association under HCV infection appear to be overweight and high glucose. Improvement of these factors may be a crucial target in preventing progression to HCC in those with HCV infection. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19115074/Metabolic_factors_and_subsequent_risk_of_hepatocellular_carcinoma_by_hepatitis_virus_infection_status:_a_large_scale_population_based_cohort_study_of_Japanese_men_and_women__JPHC_Study_Cohort_II__ DB - PRIME DP - Unbound Medicine ER -