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Prevention of hypotension after spinal anesthesia for cesarean section: 6% hydroxyethyl starch 130/0.4 (Voluven) versus lactated Ringer's solution.
J Med Liban 2008 Oct-Dec; 56(4):203-7JM

Abstract

GOALS

The aim of this study is to compare the efficacy of HES 130/0.4, a new hydroxyethyl starch, to lactated Ringer's solution (LR) in the prevention of hypotension after spinal anesthesia for cesarean section (CS).

MATERIAL AND METHODS

One hundred and twenty nonlaboring ASA I and II women having non urgent CS were enrolled in this prospective and randomized study. Subjects were randomly assigned to receive prior to anesthesia either 1 liter of LR (Gr I: n = 59) or 500 ml of HES 130/0.4 (Gr II : n = 61). Blood pressure was measured until discharge from the post anesthesia care unit. Hypotension was treated with i.v. boluses of 3 mg of ephedrine. The nausea scale was recorded. Arterial and venous umbilical blood gazes were obtained. Data were compared using Mann-Whitney U-test and Student's t-test (p < 0.05 was significant).

RESULTS

Thirty-nine patients in Gr II while 48 pts in Gr I experienced hypotension (p = .033). The total dose of ephedrine was statistically smaller in Gr II compared with Gr I (p = .001). Nausea after induction of spinal anesthesia occurred with similar frequency in both groups. Neonatal outcome was excellent and similar in both groups.

CONCLUSION

HES 130/0.4 is more effective than LR to prevent hypotension following spinal anesthesia for CS; its routine use in this purpose should be considered.

Authors+Show Affiliations

Department of Anesthesiology & Intensive Care, CHU Hôtel-Dieu de France Hospital, Beirut, Lebanon. smj20@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19115593

Citation

Madi-Jebara, Samia, et al. "Prevention of Hypotension After Spinal Anesthesia for Cesarean Section: 6% Hydroxyethyl Starch 130/0.4 (Voluven) Versus Lactated Ringer's Solution." Le Journal Medical Libanais. the Lebanese Medical Journal, vol. 56, no. 4, 2008, pp. 203-7.
Madi-Jebara S, Ghosn A, Sleilaty G, et al. Prevention of hypotension after spinal anesthesia for cesarean section: 6% hydroxyethyl starch 130/0.4 (Voluven) versus lactated Ringer's solution. J Med Liban. 2008;56(4):203-7.
Madi-Jebara, S., Ghosn, A., Sleilaty, G., Richa, F., Cherfane, A., Haddad, F., ... Antakly, M. C. (2008). Prevention of hypotension after spinal anesthesia for cesarean section: 6% hydroxyethyl starch 130/0.4 (Voluven) versus lactated Ringer's solution. Le Journal Medical Libanais. the Lebanese Medical Journal, 56(4), pp. 203-7.
Madi-Jebara S, et al. Prevention of Hypotension After Spinal Anesthesia for Cesarean Section: 6% Hydroxyethyl Starch 130/0.4 (Voluven) Versus Lactated Ringer's Solution. J Med Liban. 2008;56(4):203-7. PubMed PMID: 19115593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of hypotension after spinal anesthesia for cesarean section: 6% hydroxyethyl starch 130/0.4 (Voluven) versus lactated Ringer's solution. AU - Madi-Jebara,Samia, AU - Ghosn,Anthony, AU - Sleilaty,Ghassan, AU - Richa,Freda, AU - Cherfane,Amale, AU - Haddad,Fadia, AU - Yazigi,Alexandre, AU - Antakly,Marie-Claire, PY - 2009/1/1/entrez PY - 2009/1/1/pubmed PY - 2009/1/17/medline SP - 203 EP - 7 JF - Le Journal medical libanais. The Lebanese medical journal JO - J Med Liban VL - 56 IS - 4 N2 - GOALS: The aim of this study is to compare the efficacy of HES 130/0.4, a new hydroxyethyl starch, to lactated Ringer's solution (LR) in the prevention of hypotension after spinal anesthesia for cesarean section (CS). MATERIAL AND METHODS: One hundred and twenty nonlaboring ASA I and II women having non urgent CS were enrolled in this prospective and randomized study. Subjects were randomly assigned to receive prior to anesthesia either 1 liter of LR (Gr I: n = 59) or 500 ml of HES 130/0.4 (Gr II : n = 61). Blood pressure was measured until discharge from the post anesthesia care unit. Hypotension was treated with i.v. boluses of 3 mg of ephedrine. The nausea scale was recorded. Arterial and venous umbilical blood gazes were obtained. Data were compared using Mann-Whitney U-test and Student's t-test (p < 0.05 was significant). RESULTS: Thirty-nine patients in Gr II while 48 pts in Gr I experienced hypotension (p = .033). The total dose of ephedrine was statistically smaller in Gr II compared with Gr I (p = .001). Nausea after induction of spinal anesthesia occurred with similar frequency in both groups. Neonatal outcome was excellent and similar in both groups. CONCLUSION: HES 130/0.4 is more effective than LR to prevent hypotension following spinal anesthesia for CS; its routine use in this purpose should be considered. SN - 0023-9852 UR - https://www.unboundmedicine.com/medline/citation/19115593/Prevention_of_hypotension_after_spinal_anesthesia_for_cesarean_section:_6_hydroxyethyl_starch_130/0_4__Voluven__versus_lactated_Ringer's_solution_ L2 - https://medlineplus.gov/cesareansection.html DB - PRIME DP - Unbound Medicine ER -