Tags

Type your tag names separated by a space and hit enter

Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies.

Abstract

In vivo and in vitro studies suggest that dairy products, calcium, and dietary vitamin D inhibits the development of colorectal cancer (CRC). A meta-analysis was performed to evaluate this relationship in observational studies. Data from 60 epidemiological studies enrolling 26,335 CRC cases were pooled using a general variance-based meta-analytic method. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated for the highest vs. the lowest intake categories. Sensitivity analyses tested the robustness of these summary effect measures and the statistical heterogeneity. The summary RR for high milk and dairy product intake, respectively, on colon cancer risk was 0.78 (95% CI = 0.67-0.92) and 0.84 (95% CI = 0.75-0.95). Milk intake was unrelated to rectal cancer risk. High calcium intake had a greater protective effect against tumors of the distal colon and rectal cancer vs. proximal colon. The risk reduction associated with calcium was similar for dietary and supplemental sources. Vitamin D was associated with a nonsignificant 6% reduction in CRC risk. Higher consumption of milk/dairy products reduces the risk of colon cancer, and high calcium intake reduces the risk of CRC. Low vitamin D intake in the study populations may limit the ability to detect a protective effect if one exists.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Preventive Medicine, Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, SC 29203, USA. nfo@metaresearchgroup.org

    ,

    Source

    Nutrition and cancer 61:1 2009 pg 47-69

    MeSH

    Adult
    Aged
    Calcium, Dietary
    Case-Control Studies
    Cohort Studies
    Colonic Neoplasms
    Colorectal Neoplasms
    Dairy Products
    Female
    Humans
    Male
    Middle Aged
    Odds Ratio
    Risk Factors
    Vitamin D

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19116875

    Citation

    Huncharek, Michael, et al. "Colorectal Cancer Risk and Dietary Intake of Calcium, Vitamin D, and Dairy Products: a Meta-analysis of 26,335 Cases From 60 Observational Studies." Nutrition and Cancer, vol. 61, no. 1, 2009, pp. 47-69.
    Huncharek M, Muscat J, Kupelnick B. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer. 2009;61(1):47-69.
    Huncharek, M., Muscat, J., & Kupelnick, B. (2009). Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutrition and Cancer, 61(1), pp. 47-69. doi:10.1080/01635580802395733.
    Huncharek M, Muscat J, Kupelnick B. Colorectal Cancer Risk and Dietary Intake of Calcium, Vitamin D, and Dairy Products: a Meta-analysis of 26,335 Cases From 60 Observational Studies. Nutr Cancer. 2009;61(1):47-69. PubMed PMID: 19116875.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. AU - Huncharek,Michael, AU - Muscat,Joshua, AU - Kupelnick,Bruce, PY - 2009/1/1/entrez PY - 2009/1/1/pubmed PY - 2009/4/29/medline SP - 47 EP - 69 JF - Nutrition and cancer JO - Nutr Cancer VL - 61 IS - 1 N2 - In vivo and in vitro studies suggest that dairy products, calcium, and dietary vitamin D inhibits the development of colorectal cancer (CRC). A meta-analysis was performed to evaluate this relationship in observational studies. Data from 60 epidemiological studies enrolling 26,335 CRC cases were pooled using a general variance-based meta-analytic method. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated for the highest vs. the lowest intake categories. Sensitivity analyses tested the robustness of these summary effect measures and the statistical heterogeneity. The summary RR for high milk and dairy product intake, respectively, on colon cancer risk was 0.78 (95% CI = 0.67-0.92) and 0.84 (95% CI = 0.75-0.95). Milk intake was unrelated to rectal cancer risk. High calcium intake had a greater protective effect against tumors of the distal colon and rectal cancer vs. proximal colon. The risk reduction associated with calcium was similar for dietary and supplemental sources. Vitamin D was associated with a nonsignificant 6% reduction in CRC risk. Higher consumption of milk/dairy products reduces the risk of colon cancer, and high calcium intake reduces the risk of CRC. Low vitamin D intake in the study populations may limit the ability to detect a protective effect if one exists. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/19116875/Colorectal_cancer_risk_and_dietary_intake_of_calcium_vitamin_D_and_dairy_products:_a_meta_analysis_of_26335_cases_from_60_observational_studies_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580802395733 DB - PRIME DP - Unbound Medicine ER -