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Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies.
Nutr Cancer. 2009; 61(1):47-69.NC

Abstract

In vivo and in vitro studies suggest that dairy products, calcium, and dietary vitamin D inhibits the development of colorectal cancer (CRC). A meta-analysis was performed to evaluate this relationship in observational studies. Data from 60 epidemiological studies enrolling 26,335 CRC cases were pooled using a general variance-based meta-analytic method. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated for the highest vs. the lowest intake categories. Sensitivity analyses tested the robustness of these summary effect measures and the statistical heterogeneity. The summary RR for high milk and dairy product intake, respectively, on colon cancer risk was 0.78 (95% CI = 0.67-0.92) and 0.84 (95% CI = 0.75-0.95). Milk intake was unrelated to rectal cancer risk. High calcium intake had a greater protective effect against tumors of the distal colon and rectal cancer vs. proximal colon. The risk reduction associated with calcium was similar for dietary and supplemental sources. Vitamin D was associated with a nonsignificant 6% reduction in CRC risk. Higher consumption of milk/dairy products reduces the risk of colon cancer, and high calcium intake reduces the risk of CRC. Low vitamin D intake in the study populations may limit the ability to detect a protective effect if one exists.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, SC 29203, USA. nfo@metaresearchgroup.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19116875

Citation

Huncharek, Michael, et al. "Colorectal Cancer Risk and Dietary Intake of Calcium, Vitamin D, and Dairy Products: a Meta-analysis of 26,335 Cases From 60 Observational Studies." Nutrition and Cancer, vol. 61, no. 1, 2009, pp. 47-69.
Huncharek M, Muscat J, Kupelnick B. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer. 2009;61(1):47-69.
Huncharek, M., Muscat, J., & Kupelnick, B. (2009). Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutrition and Cancer, 61(1), 47-69. https://doi.org/10.1080/01635580802395733
Huncharek M, Muscat J, Kupelnick B. Colorectal Cancer Risk and Dietary Intake of Calcium, Vitamin D, and Dairy Products: a Meta-analysis of 26,335 Cases From 60 Observational Studies. Nutr Cancer. 2009;61(1):47-69. PubMed PMID: 19116875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. AU - Huncharek,Michael, AU - Muscat,Joshua, AU - Kupelnick,Bruce, PY - 2009/1/1/entrez PY - 2009/1/1/pubmed PY - 2009/4/29/medline SP - 47 EP - 69 JF - Nutrition and cancer JO - Nutr Cancer VL - 61 IS - 1 N2 - In vivo and in vitro studies suggest that dairy products, calcium, and dietary vitamin D inhibits the development of colorectal cancer (CRC). A meta-analysis was performed to evaluate this relationship in observational studies. Data from 60 epidemiological studies enrolling 26,335 CRC cases were pooled using a general variance-based meta-analytic method. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated for the highest vs. the lowest intake categories. Sensitivity analyses tested the robustness of these summary effect measures and the statistical heterogeneity. The summary RR for high milk and dairy product intake, respectively, on colon cancer risk was 0.78 (95% CI = 0.67-0.92) and 0.84 (95% CI = 0.75-0.95). Milk intake was unrelated to rectal cancer risk. High calcium intake had a greater protective effect against tumors of the distal colon and rectal cancer vs. proximal colon. The risk reduction associated with calcium was similar for dietary and supplemental sources. Vitamin D was associated with a nonsignificant 6% reduction in CRC risk. Higher consumption of milk/dairy products reduces the risk of colon cancer, and high calcium intake reduces the risk of CRC. Low vitamin D intake in the study populations may limit the ability to detect a protective effect if one exists. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/19116875/Colorectal_cancer_risk_and_dietary_intake_of_calcium_vitamin_D_and_dairy_products:_a_meta_analysis_of_26335_cases_from_60_observational_studies_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580802395733 DB - PRIME DP - Unbound Medicine ER -