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Occurrence of systemic lupus erythematosus in a Danish community: an 8-year prospective study.
Scand J Rheumatol 2009 Mar-Apr; 38(2):128-32SJ

Abstract

OBJECTIVES

To determine the prevalence and annual incidence of definite systemic lupus erythematosus (D-SLE) and incomplete SLE (I-SLE) in a community-based lupus cohort of predominantly Nordic ancestry in an 8-year prospective study from 1995 to 2003, and also to calculate the annual transition rate of I-SLE to D-SLE.

METHODS

In 1995 all SLE patients in the county of Funen were retrieved from four separate and independent sources. Incident cases were subsequently identified by surveillance of these sources.

RESULTS

During the 8-year study period the median annual incidence of D-SLE (1.04 per 100 000) and I-SLE (0.36 per 100 000) remained almost constant. The point prevalence (PP) of D-SLE increased from 21.9 to 28.3 per 100 000, and from 6.19 to 7.53 per 100 000 for I-SLE. During follow-up, seven I-SLE patients transformed into D-SLE at a progression rate of 3.64 per 100 person-years at risk [95% confidence interval (CI) 1.44-7.55].

CONCLUSIONS

Denmark is a low-incidence lupus area but lupus prevalence is increasing slowly. I-SLE is a disease variant that may eventually convert into D-SLE.

Authors+Show Affiliations

Department of Rheumatology, Odense University Hospital, Odense, Denmark. helle.laustrup@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19117248

Citation

Laustrup, H, et al. "Occurrence of Systemic Lupus Erythematosus in a Danish Community: an 8-year Prospective Study." Scandinavian Journal of Rheumatology, vol. 38, no. 2, 2009, pp. 128-32.
Laustrup H, Voss A, Green A, et al. Occurrence of systemic lupus erythematosus in a Danish community: an 8-year prospective study. Scand J Rheumatol. 2009;38(2):128-32.
Laustrup, H., Voss, A., Green, A., & Junker, P. (2009). Occurrence of systemic lupus erythematosus in a Danish community: an 8-year prospective study. Scandinavian Journal of Rheumatology, 38(2), pp. 128-32. doi:10.1080/03009740802419073.
Laustrup H, et al. Occurrence of Systemic Lupus Erythematosus in a Danish Community: an 8-year Prospective Study. Scand J Rheumatol. 2009;38(2):128-32. PubMed PMID: 19117248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Occurrence of systemic lupus erythematosus in a Danish community: an 8-year prospective study. AU - Laustrup,H, AU - Voss,A, AU - Green,A, AU - Junker,P, PY - 2009/1/2/entrez PY - 2009/1/2/pubmed PY - 2009/3/27/medline SP - 128 EP - 32 JF - Scandinavian journal of rheumatology JO - Scand. J. Rheumatol. VL - 38 IS - 2 N2 - OBJECTIVES: To determine the prevalence and annual incidence of definite systemic lupus erythematosus (D-SLE) and incomplete SLE (I-SLE) in a community-based lupus cohort of predominantly Nordic ancestry in an 8-year prospective study from 1995 to 2003, and also to calculate the annual transition rate of I-SLE to D-SLE. METHODS: In 1995 all SLE patients in the county of Funen were retrieved from four separate and independent sources. Incident cases were subsequently identified by surveillance of these sources. RESULTS: During the 8-year study period the median annual incidence of D-SLE (1.04 per 100 000) and I-SLE (0.36 per 100 000) remained almost constant. The point prevalence (PP) of D-SLE increased from 21.9 to 28.3 per 100 000, and from 6.19 to 7.53 per 100 000 for I-SLE. During follow-up, seven I-SLE patients transformed into D-SLE at a progression rate of 3.64 per 100 person-years at risk [95% confidence interval (CI) 1.44-7.55]. CONCLUSIONS: Denmark is a low-incidence lupus area but lupus prevalence is increasing slowly. I-SLE is a disease variant that may eventually convert into D-SLE. SN - 1502-7732 UR - https://www.unboundmedicine.com/medline/citation/19117248/Occurrence_of_systemic_lupus_erythematosus_in_a_Danish_community:_an_8_year_prospective_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/03009740802419073 DB - PRIME DP - Unbound Medicine ER -