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Autologous transplantation of retinal pigment epithelium-Bruch's membrane complex for hemorrhagic age-related macular degeneration.
Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2975-81.IO

Abstract

PURPOSE

To evaluate a surgical procedure for patients with hemorrhagic age-related macular degeneration (AMD).

METHODS

This procedure consisted of excision of the choroidal neovascular membrane and transplantation of autologous retinal pigment epithelium (RPE)-Bruch's membrane complex. The RPE-Bruch's membrane complex for transplantation was surgically developed by dissecting Bruch's membrane with the choriocapillaris from the medium size choroidal vessel layer at the midperipheral region of the choroid. Twenty-one eyes of 21 patients had this surgical procedure. Visual function tests included best corrected visual acuity (BCVA), multifocal (mf)ERG, and microperimetry. Optical coherence tomography (OCT), fluorescein angiography, and autofluorescence examinations were performed to study the status of the transplanted graft.

RESULTS

Among the 21 eyes, 17 with complete clinical data and qualified follow-up durations, which were 20.35 +/- 10.31 months on average, were analyzed in this series. On the last follow-up visit, the mean for the ETDRS scores increased from 28.65 +/- 23.99 before surgery to 47.76 +/- 17.22 after surgery. Microperimetry showed that after surgery, seven eyes gained central fixation at the 12-month follow-up examination. However, two eyes lost their central fixation on the last follow-up visit. Fourteen (82.35%) of the transplanted patches preserved normal color without depigmentation. Among the 21 eyes, proliferative vitreoretinopathy (PVR) occurred in 3 (14.29%), and a recurrent neovascular membrane was observed in one eye (4.76%).

CONCLUSIONS

The transplantation of the autologous RPE-Bruch's membrane complex can increase the visual acuity of patients with hemorrhagic AMD. The surviving transplanted graft with functional overlying retina was observed after surgery.

Authors+Show Affiliations

Peking University Eye Center, Peking University Third Hospital, Beijing, Peoples Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19117919

Citation

Ma, Zhizhong, et al. "Autologous Transplantation of Retinal Pigment epithelium-Bruch's Membrane Complex for Hemorrhagic Age-related Macular Degeneration." Investigative Ophthalmology & Visual Science, vol. 50, no. 6, 2009, pp. 2975-81.
Ma Z, Han L, Wang C, et al. Autologous transplantation of retinal pigment epithelium-Bruch's membrane complex for hemorrhagic age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50(6):2975-81.
Ma, Z., Han, L., Wang, C., Dou, H., Hu, Y., Feng, X., Xu, Y., Wang, Z., Yin, Z., & Liu, Y. (2009). Autologous transplantation of retinal pigment epithelium-Bruch's membrane complex for hemorrhagic age-related macular degeneration. Investigative Ophthalmology & Visual Science, 50(6), 2975-81. https://doi.org/10.1167/iovs.08-2573
Ma Z, et al. Autologous Transplantation of Retinal Pigment epithelium-Bruch's Membrane Complex for Hemorrhagic Age-related Macular Degeneration. Invest Ophthalmol Vis Sci. 2009;50(6):2975-81. PubMed PMID: 19117919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autologous transplantation of retinal pigment epithelium-Bruch's membrane complex for hemorrhagic age-related macular degeneration. AU - Ma,Zhizhong, AU - Han,Liang, AU - Wang,Changguan, AU - Dou,Hongliang, AU - Hu,Yuntao, AU - Feng,Xuefeng, AU - Xu,Yimin, AU - Wang,Zhiqiang, AU - Yin,Zhengqin, AU - Liu,Yuling, Y1 - 2008/12/30/ PY - 2009/1/2/entrez PY - 2009/1/2/pubmed PY - 2009/6/12/medline SP - 2975 EP - 81 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 50 IS - 6 N2 - PURPOSE: To evaluate a surgical procedure for patients with hemorrhagic age-related macular degeneration (AMD). METHODS: This procedure consisted of excision of the choroidal neovascular membrane and transplantation of autologous retinal pigment epithelium (RPE)-Bruch's membrane complex. The RPE-Bruch's membrane complex for transplantation was surgically developed by dissecting Bruch's membrane with the choriocapillaris from the medium size choroidal vessel layer at the midperipheral region of the choroid. Twenty-one eyes of 21 patients had this surgical procedure. Visual function tests included best corrected visual acuity (BCVA), multifocal (mf)ERG, and microperimetry. Optical coherence tomography (OCT), fluorescein angiography, and autofluorescence examinations were performed to study the status of the transplanted graft. RESULTS: Among the 21 eyes, 17 with complete clinical data and qualified follow-up durations, which were 20.35 +/- 10.31 months on average, were analyzed in this series. On the last follow-up visit, the mean for the ETDRS scores increased from 28.65 +/- 23.99 before surgery to 47.76 +/- 17.22 after surgery. Microperimetry showed that after surgery, seven eyes gained central fixation at the 12-month follow-up examination. However, two eyes lost their central fixation on the last follow-up visit. Fourteen (82.35%) of the transplanted patches preserved normal color without depigmentation. Among the 21 eyes, proliferative vitreoretinopathy (PVR) occurred in 3 (14.29%), and a recurrent neovascular membrane was observed in one eye (4.76%). CONCLUSIONS: The transplantation of the autologous RPE-Bruch's membrane complex can increase the visual acuity of patients with hemorrhagic AMD. The surviving transplanted graft with functional overlying retina was observed after surgery. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/19117919/Autologous_transplantation_of_retinal_pigment_epithelium_Bruch's_membrane_complex_for_hemorrhagic_age_related_macular_degeneration_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.08-2573 DB - PRIME DP - Unbound Medicine ER -