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Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation.
Ann Diagn Pathol. 2009 Feb; 13(1):36-40.AD

Abstract

Cases of cerebral neuroblastoma or supratentorial primitive neuroectodermal tumor with malignant gliomatous components are relatively uncommon. Less frequent is the combination of these 2 elements with a mesenchymal component. This is a case report of a lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation occurring in a 48-year-old woman. She presented with headaches and confusion. A right parietal lobe mass was excised and subsequently recurred, requiring additional surgery 10 months later. The patient died 13 months after initial surgery. Histologic findings showed a proliferation of small rounded synaptophysin-positive neural cells consistent with neuroblastoma. These cells were arranged against a benign lipomatous background. The second resection consisted primarily of glioblastomatous-like tissue with intermixed lipomatous component. The glioblastoma component was marked by prominent cellularity, moderate nuclear pleomorphism, readily identifiable mitotic activity, vascular proliferative changes, and necrosis. The glioblastomatous component of the tumor demonstrated glial fibrillary acidic protein immunoreactivity. A Ki-67 labeling index of 18.9% was noted in the initial resection. The literature on similar-appearing lesions is reviewed.

Authors+Show Affiliations

Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. Praysor@ccf.org

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19118780

Citation

Prayson, Richard A.. "Lipomatous Supratentorial Primitive Neuroectodermal Tumor With Glioblastomatous Differentiation." Annals of Diagnostic Pathology, vol. 13, no. 1, 2009, pp. 36-40.
Prayson RA. Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation. Ann Diagn Pathol. 2009;13(1):36-40.
Prayson, R. A. (2009). Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation. Annals of Diagnostic Pathology, 13(1), 36-40. https://doi.org/10.1016/j.anndiagpath.2007.04.009
Prayson RA. Lipomatous Supratentorial Primitive Neuroectodermal Tumor With Glioblastomatous Differentiation. Ann Diagn Pathol. 2009;13(1):36-40. PubMed PMID: 19118780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation. A1 - Prayson,Richard A, Y1 - 2007/10/24/ PY - 2009/1/3/entrez PY - 2009/1/3/pubmed PY - 2009/4/4/medline SP - 36 EP - 40 JF - Annals of diagnostic pathology JO - Ann Diagn Pathol VL - 13 IS - 1 N2 - Cases of cerebral neuroblastoma or supratentorial primitive neuroectodermal tumor with malignant gliomatous components are relatively uncommon. Less frequent is the combination of these 2 elements with a mesenchymal component. This is a case report of a lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation occurring in a 48-year-old woman. She presented with headaches and confusion. A right parietal lobe mass was excised and subsequently recurred, requiring additional surgery 10 months later. The patient died 13 months after initial surgery. Histologic findings showed a proliferation of small rounded synaptophysin-positive neural cells consistent with neuroblastoma. These cells were arranged against a benign lipomatous background. The second resection consisted primarily of glioblastomatous-like tissue with intermixed lipomatous component. The glioblastoma component was marked by prominent cellularity, moderate nuclear pleomorphism, readily identifiable mitotic activity, vascular proliferative changes, and necrosis. The glioblastomatous component of the tumor demonstrated glial fibrillary acidic protein immunoreactivity. A Ki-67 labeling index of 18.9% was noted in the initial resection. The literature on similar-appearing lesions is reviewed. SN - 1532-8198 UR - https://www.unboundmedicine.com/medline/citation/19118780/Lipomatous_supratentorial_primitive_neuroectodermal_tumor_with_glioblastomatous_differentiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1092-9134(07)00055-X DB - PRIME DP - Unbound Medicine ER -